Background Cardiac amyloidosis is a progressive disease with high mortality that requires accurate differentiation between AL and ATTR types for optimal treatment selection. Cardiac MRI with contrast enhancement and myocardial strain analysis may play a crucial role in diagnosing amyloid cardiomyopathy subtypes. Objective To evaluate the capabilities of cardiac MRI, including myocardial strain analysis and late gadolinium enhancement (LGE) patterns, in the differential diagnosis of AL and ATTR cardiac amyloidosis. Materials and Methods A retrospective analysis was conducted using data from 25 patients with confirmed cardiac amyloidosis (12 AL, 13 ATTR). Structural parameters (wall thickness, myocardial mass), left ventricular volumetric characteristics, global and regional myocardial strain parameters (strain analysis), and LGE patterns were evaluated. Standard statistical methods were applied with p<0.050 considered significant. Results Patients with ATTR amyloidosis demonstrated more pronounced myocardial wall thickening (LV interventricular septum 17.8±2.3 mm vs 13.8±2.4 mm; LV posterior wall 14.2±2.4 mm vs 10.8±2 mm, p<0.010) and greater LV myocardial mass (110±30 vs 83±17 g/m², p<0.010) compared to AL amyloidosis. Significant differences in myocardial strain parameters were identified:• 2D circumferential strain: AL -13.46±3.46% vs ATTR -10.65±3.95% (p=0.029); threshold value -14.51% (sensitivity 100%, specificity 56%)• 2D longitudinal strain: AL -10.95±3.81% vs ATTR -8.38±2.19% (p=0.048); threshold value -10.98% (sensitivity 100%, specificity 50%)Analysis of enhancement patterns revealed that ATTR amyloidosis more frequently demonstrated transmural LGE in the basal and mid inferolateral segments, while AL amyloidosis more often showed subendocardial enhancement primarily in the mid anterolateral and inferolateral segments (p<0.050). Simultaneous contrast enhancement in the subendocardial layers of both LV and RV within the interventricular septum was characteristic of ATTR amyloidosis (100% vs 50%, p<0.010). Right ventricular LGE was more common in ATTR (100% vs 58%, p<0.050). Quantitative assessment of LGE using the QALE scale showed more extensive enhancement in ATTR (13[12;14] vs 10.5[1.75;12] points, p<0.010), and a score greater than 13 allowed differentiation of these amyloidosis types with 69% sensitivity and 83% specificity. Conclusion Comprehensive evaluation of cardiac MRI parameters can improve the diagnostic accuracy of AL and ATTR amyloidosis, which has important clinical significance. LV circumferential and longitudinal myocardial strain, as well as characteristic contrast enhancement patterns, can serve as additional criteria for differentiating between amyloidosis types.

A growing number of studies are focusing on the possibilities of [68Ga]Ga-FAPI PET/CT in diagnosis of tumors of various localizations. It has been established that [68Ga]Ga-FAPI PET/CT has high diagnostic efficiency in head and neck tumors, lung cancer, breast cancer, abdominal tumors, as well as in sarcomas, both in the primary tumor detection and in search of distant metastases. The aim of this study is to evaluate the performance of [68Ga]Ga-FAPI PET/CT for the diagnosis of bone and soft tissue sarcoma, compared with [18F]FDG PET/CT. We screened all patients (pts) who underwent dual-tracer [68Ga]Ga-FAPI and [18F]FDG PET/CT from 2022–2025. Both examinations were performed within 1 week for assessment of primary tumor, local relapse or distant metastasis. Positive lesions on PET/CT images were verified by biopsy, 3–12-month follow-up and MRI/contrast-enhanced CT. A paired t test was used to compare the semiquantitative values (SUVmax and TBR) of [18F]FDG and [68Ga]Ga-FAPI PET/CT in tumor lesions. Primary tumors in patients were detected by morphological verification. To evaluate metastases in other organs and lymph nodes, we used histological data, MRI or dynamic follow-up. These results were used to calculate the diagnostic efficiency (sensitivity (Se), specificity (Sp), positive predictive value (PPV), negative predictive value (NPV) and accuracy (Ac)) for each modality on a per-region basis. Twenty-six patients (15 women and 11 men; average age – 44 years) representing 17 sarcoma subtypes were included in the final analysis. A total of 128 tumor lesions were identified. Compared with [18F]FDG, [68Ga]Ga-FAPI demonstrated significantly higher uptake in dedifferentiated liposarcoma, malignant solitary fibrous tumors, and fibrosarcoma (mean SUVmax: 29.26 ± 16.90 vs. 5.93 ± 5.60; p < 0.001). Conversely, [18F]FDG demonstrated higher uptake intensity in synovial sarcoma, pleomorphic sarcoma, leiomyosarcoma, and intimal sarcoma (mean SUVmax: 10.77 ± 4.64 vs. 5.24 ± 2.24; p = 0.0089). On a per-region basis, [68Ga]Ga-FAPI yielded a sensitivity of 68.52

Long-duration spaceflight represents an extreme challenge, triggering adaptive responses including spaceflight-associated neuro-ocular syndrome, characterized by diminished visual acuity and ocular changes, which is a significant health risk for Mars missions. Concurrently, spacefarers experience brain adaptations, including ventricular expansion and CSF redistribution; however, the integrative physiological mechanisms linking these brain-eye responses remain unestablished. We applied automated morphometric analysis to investigate brain-eye relationships using high-resolution MRI data from terrestrial control subjects and spacefarers, conducting correlation analysis between third ventricle volume and ocular parameters. Analysis revealed significant baseline correlations between third ventricle volume and multiple ocular parameters in healthy control subjects, including globe dimensions, optic nerve sheath volume, optic nerve length and retro-orbital width. Following spaceflight, adaptations occurred: optic nerve sheath volume increased by 11.93 ± 6.07 mm3 (right) and 27.22 ± 8.74 mm3 (left), and optic nerves lengthened by 0.38 mm (right) and 0.47 mm (left). The baseline analysis showed that multiple orbital structures were correlated with third ventricle volume, whereas longitudinal change analysis revealed selective associations: only globe changes were correlated with third ventricle expansion. This study demonstrates structure-specific brain-eye relationships consistent with CSF-mediated coupling as a mechanism underlying spaceflight-associated neuro-ocular syndrome during the cranial microgravity response. Following spaceflight, third ventricle expansion is correlated selectively with globe changes, while dissociating from optic nerve sheath and retro-orbital adaptations, providing quantitative evidence that microgravity creates differential biomechanical effects across orbital compartments. This supports CSF compartmentalization and the limited intracranial volume expansion (cranial ceiling effect) as underlying mechanisms. The findings illuminate the limits of brain elastic tissue expansion during intracranial fluid accumulation in astronauts.

Accurate preoperative staging of bladder cancer on MRI remains challenging because visual reads vary across observers. We investigated a multiparametric MRI (mpMRI) radiomics approach to predict muscle invasion (≥T2) and prospectively tested it on a validation cohort. Eighty-four patients with urothelial carcinoma underwent 1.5-T mpMRI per VI-RADS (T2-weighted imaging and DWI-derived ADC maps). Two blinded radiologists performed 3D tumor segmentation; 37 features per sequence were extracted (LifeX) using absolute resampling. In the training cohort (n = 40), features that differed between non-muscle-invasive and muscle-invasive tumors (Mann–Whitney p < 0.05) underwent ROC analysis with cut-offs defined by the Youden index. A compact descriptor combining GLRLM-LRLGE from T2 and GLRLM-SRLGE from ADC was then fixed and applied without re-selection to a prospective validation cohort (n = 44). Histopathology within 6 weeks—TURBT or cystectomy—served as the reference. Eleven T2-based and fifteen ADC-based features pointed to invasion; DWI texture features were not informative. The descriptor yielded AUCs of 0.934 (training) and 0.871 (validation) with 85.7% sensitivity and 96.2% specificity in validation. Collectively, these findings indicate that combined T2/ADC radiomics can provide high diagnostic accuracy and may serve as a useful decision support tool, after multicenter, multi-vendor validation.

Microgravity exposure induces cardiac deconditioning, primarily due to hypovolemia and inactivity. Animal models suggest microgravity may cause left ventricular (LV) papillary muscle atrophy, but this has not been studied in humans. This study used MRI to assess LV papillary muscle mass and LV morphology and function in nine male cosmonauts before and 6 ± 2 days after long-duration spaceflight (247 ± 90 days). Spaceflight did not affect LV volumes, ejection fraction, and strain parameters, but increased heart rate (P < 0.001) and cardiac output (P = 0.03). LV papillary muscle mass decreased by 14% (P = 0.017), while LV mass tended to increase (P = 0.083), mitral annular diameter increased (P = 0.004) without mitral leakage, and LV sphericity increased (P = 0.02). These findings suggest LV adapts to space with geometric changes, but microgravity-induced papillary muscle atrophy requires further study for long-term implications.

This article provides a short overview about existing imaging techniques in the diagnosis of acute pulmonary embolism. Was analyzed scientific papers by domestic and foreign authors. A review of the diagnostic algorithm, features and current difficulties for risk stratification of patients with suspected acute pulmonary embolism was conducted. The main aspects of imaging in acute thromboembolism and parameters for assessing severity are noted. The contribution of relatively new perfusion diagnostic methods, such as dual-energy computed tomography angiopulmonography, computed tomography angiopulmonography with subtraction and magnetic resonance angiopulmonography is covered. The great interest is using additional and alternativ methods of radiologic visualisation for the diagnostic acute pulmonary thromboembolism despite the existence the methods of choice. Particular attention is paid for computed tomography with the ability iodine mapping for indirect assessment of perfusion and the experience of using this method in practice. Attention is paid to the feasibility of using various visualization methods in the diagnosis of acute pulmonary embolism, highlighting the various advantages and future prospects in emergency medical care.

The differential diagnosis of an echocardiographically detected intracardiac mass in the mitral annulus can be challenging and usually requires a multimodal approach. This type of lesion is very often associated with subvalvular calcification of the mitral valve. The rare, caseous, variant is the most difficult to diagnose. This case series highlights the clinical significance of computed tomography in detecting and characterizing subvalvular mitral annular calcification when other modalities, particularly echocardiography, are inconclusive. The aim of this article was to raise awareness among specialists of the classic signs of caseous subvalvular calcification of the mitral annulus when visualized with different modalities. Special attention is also given to providing a differential diagnostic series that identifies features that differentiate subvalvular calcification of the mitral annulus from other conditions at this site. Healthcare professionals need to be aware of these mitral valve lesions in order to predict possible associated complications and plan a treatment strategy that may help avoid unnecessary surgical procedures in some cases.

Left ventricular (LV) hypertrophy implies structural cardiac changes and, as a consequence, an increase in myocardial mass. Currently, there are many causes of this condition as follows: hypertension, aortic stenosis, hypertrophic cardiomyopathy, exercise, storage diseases (AL, ATTR amyloidosis, Danon disease, Anderson-­Fabry disease, etc.), metabolic disorders. Despite the currently existing diagnostic algorithms for LV hypertrophy, establishing a correct diagnosis can take a long time, and controversial research results can lead to false conclusions. This article presents a case report of a patient with LV hypertrophy, an atypical clinical performance and ambiguous paraclinical data, which led to certain diagnostic difficulties.

BACKGROUND: Mitral valve calcinosis is a chronic degenerative process in the fibrous structures of the mitral valve. Advanced stages increase the risk of endocarditis and cardiac rhythm disturbances and contribute to cardiovascular mortality. The cause of mitral valve calcinosis is still controversial; however, the contribution of atherosclerosis to its development is currently undisputed. The prevalence of mitral valve calcinosis varies in different age groups and on average is higher in people with cardiovascular disease. AIM: To assess the prevalence of mitral valve calcinosis in patients undergoing computed tomography angiography and identify the relationship between aortic and mitral valve calcinosis and coronary calcium index and signs of remodeling. MATERIALS AND METHODS: A retrospective study of 336 patients who underwent computed tomography coronary angiography with intravenous contrast enhancement at the Lomonosov Moscow State University Clinic between November 13, 2020, and May 14, 2022, was conducted. RESULTS: The prevalence of aortic (16.4%) and mitral (11%) valve calcinosis was high in people undergoing cardiovascular examination, and a relationship was noted between valve calcinosis and coronary calcium index. CONCLUSION: The detection of mitral valve calcinosis in patients during routine examination is important in predicting further treatment and outcomes because valve calcinosis is an indirect indicator of coronary heart disease risk. Although valve calcinosis is usually an incidental examination finding, it may indicate a high cardiovascular risk and should prompt further evaluation, if clinically necessary.

Актуальность подготовки учебно-методического пособия по лучевым методам диагностики легочной гипертензии для ординаторов и врачей-рентгенологов обусловлена возрастающей частотой и тяжестью легочной гипертензии, значительно отягощающей прогноз и качество жизни пациента, многообразием причин, приводящих к развитию этого грозного осложнения. Врачи практического здравоохранения должны быть знакомы с возможностями современных методов визуализации в выявлении легочной гипертензии, так как своевременное выявление и диагностика легочной гипертензии позволяет применить целый спектр методов лечения, от консервативных до хирургических, благоприятно влияющих на прогноз больных с легочной гипертензией. Пособие разработано в соответствии с Федеральным государственным образовательным стандартом высшего образования - подготовка кадров высшей квалификации по программам ординатуры по специальности 31.08.09 Рентгенология. Учебно-методическое пособие может быть использовано в образовательном процессе ординаторов, аспирантов, врачей-рентгенологов.

Aim. The aim of this study was to evaluate the clinical and cost-effectiveness of computed tomography angiography (CTA), which includes CT coronary angiography and a “triple rule-out” protocol, in intermediate-risk patients with suspected non-ST-segment elevation acute coronary syndrome (NSTEACS) in the emergency room (ER) of the regional vascular center in the structure of a multidisciplinary hospital in Moscow.Material and methods. This continuous single-site study included patients hospitalized in a multidisciplinary hospital with a referral diagnosis of NSTEACS within 69 days. Patients at intermediate risk who met the inclusion criteria underwent CTA after the initial examination in the ER. If coronary artery disease or an alternative significant diagnosis was excluded, patients were discharged from the hospital on the day of admission. As a comparison method, the costs of treating these patients were assessed if a standard protocol was used. According to this protocol, patients, after the initial examination, were hospitalized in the intensive care unit for patients with myocardial infarction (ICU-MI) and then in the cardiology department for observation and further examination. Clinical economic analysis was performed using the cost minimization method and the tariff method of cost estimation.Results. For 69 days, 289 patients (59.5% men, mean age 71.7±8.6 years) were admitted to the ER with a referral diagnosis of NSTEACS. In 30 of them, a non-cardiological disease was identified that required routing to other specialized units. 37 (14.3%) of intermediate-risk patients underwent CTA. In 27 of them (10% of all patients), no significant coronary stenosis, signs of pulmonary embolism (PE), or aortic dissection were detected, and the patients were discharged from the ER. 10 patients (4% of all patients) who had significant coronary artery stenoses, PE, or aortic dissection were hospitalized. 72 intermediate-risk patients had exclusion criteria for CTA. The economic benefit from using CTA for excluding ACS in the ER, as compared to the standard approach, was 1,602,450 rubles for the study period. The estimated benefit per year was 8,476,728 rubles.Conclusion. The introduction of CTA and the “triple rule-out” protocol for intermediate-risk patients in the ER can significantly improve the process of excluding the diagnosis of NSTEACS, reduce the number of unnecessary hospitalizations and optimize the use of hospital capacity. According to the results of our study, this approach is applicable in at least 14% of patients with suspected NSTEACS (at least 33% of intermediate-risk patients).

Radiomics and texture analysis is a new step in the evaluation of digital medical images using specialized software and quantitative assessment of signs invisible to the eye. The textural parameters obtained through mathematical transformations correlate with morphological, molecular, and genotypic characteristics of the examined area. This article reviews scientific studies on challenges and benefits of using texture analysis in diagnosis of bladder cancer. The authors describe the practical value of this approach, and consider the challenges and potential of using it. Forty publications published between 2016 and 2024 were selected using keywords from PubMed and Google Scholar. Multiple studies demonstrate high accuracy of radiomics in local staging of bladder cancer, morphologic assessment of the tumor, and prediction of long-term clinical outcomes. Therefore, texture analysis of medical images can provide additional information to diagnose bladder cancer in uncertain cases. Standardization of the method is currently one of the key issues to accelerate implementation of radiomics analysis in clinical practice.

A genetic diagnosis of primary cardiomyopathies can be a long-unmet need in patients with complex phenotypes. We investigated a three-generation family with cardiomyopathy and various extracardiac abnormalities that had long sought a precise diagnosis. The 41-year-old proband had hypertrophic cardiomyopathy (HCM), left ventricular noncompaction, myocardial fibrosis, arrhythmias, and a short stature. His sister showed HCM, myocardial hypertrabeculation and fibrosis, sensorineural deafness, and congenital genitourinary malformations. Their father had left ventricular hypertrophy (LVH). The proband’s eldest daughter demonstrated developmental delay and seizures. We performed a clinical examination and whole-exome sequencing for all available family members. All patients with HCM/LVH shared a c.4411-2A>C variant in ALPK3, a recently known HCM-causative gene. Functional studies confirmed that this variant alters ALPK3 canonical splicing. Due to extracardiac symptoms in the female patients, we continued the search and found two additional single-gene disorders. The proband’s sister had a p.Trp329Gly missense in GATA3, linked to hypoparathyroidism, sensorineural deafness, and renal dysplasia; his daughter had a p.Ser251del in WDR45, associated with beta-propeller protein-associated neurodegeneration. This unique case of three monogenic disorders in one family shows how a comprehensive approach with thorough phenotyping and extensive genetic testing of all symptomatic individuals provides precise diagnoses and appropriate follow-up, embodying the concept of personalized medicine. We also present the first example of a splicing functional study for ALPK3 and describe the genotype–phenotype correlations in cardiomyopathy.

Aim. To study the clinical manifestations, incidence of life-threatening complications, and their possible mechanisms and outcomes of left ventricular non-compaction (LVNC) in adults.Material and methods. This study included 125 adult patients with LVNC, 74 men (59.2%) and 51 women (40.8%) aged 46.4±15.1 years. Echocardiography (EchoCG) (n=125), Holter monitoring (n=125), cardiac magnetic resonance imaging (MRI) (n=60), and contrast-enhanced multislice computed tomography (MSCT) of the heart (n=90), and, if indicated, coronary angiography (CAG) (n=33) and myocardial scintigraphy (n=27) were performed. The diagnosis of LVNC was confirmed in 74 cases using two methods, and in 21 cases, using three imaging methods. DNA diagnostics was performed in most patients. For most patients, the level of anticardiac antibodies and the genome of cardiotropic viruses were determined in the blood. Mean left ventricular (LV) ejection fraction (EF) was 38.6±14.0%; LV end-diastolic volume (EDV) was 158.1±67.8 ml; LV end-diastolic dimension (EDD) was 6.1±0.9 cm; and left atrial (LA) volume was 97.1±38.1 ml. The mean follow-up period was 14 months [4.0; 41.0]; from 1 month to 10 years.Results. Death rate was 14.4%; heart transplantation was performed in 5.6% of cases. Nonsustained ventricular tachycardia (VT) was detected in 45.6% of cases and sustained VT in 13.6%. The presence of VT was associated with poor R-wave progression in the precordial ECG leads, low QRS voltage, QRS duration >105 ms, NYHA chronic heart failure functional class (CHF FC) ≥2-3, LV EF <40%; LV EDD >6.1 cm, the presence of myocarditis, and higher death rate. Cardioverter defibrillators, including cardiac resynchronization therapy defibrillators (CRTD), were implanted in 38 patients. Appropriate defibrillator shocks were associated with frequent premature ventricular contractions (PVCs). The incidence of thrombosis and embolism was 22.4%. Their predictors included CHF FC ≥2-3, RV anteroposterior dimension >3.1 cm, LA volume >98 ml, E/A >1.65, LV EDD >6.3 cm, LV EDV >153 ml, LV EF <35%, and myocardial necrosis of unknown origin (in patients without coronary atherosclerosis). The incidence of myocardial necrosis in LVNC was 16.0%. The mechanisms identified, in addition to coronary atherosclerosis, were embolism in unchanged coronary arteries, secondary myocarditis, and the presence of genetically determined thrombophilia.Conclusion. LVNC is associated with a high risk of life-threatening conditions, such as ventricular arrhythmias, thrombosis and embolism, and myocardial necrosis, that are typical complications of LVNC in adults. Reassessing the predictors for the risk of thromboembolic and arrhythmic events, specifying the indications for implantable cardioverter defibrillator and anticoagulants, and actively identifying and treating concomitant myocarditis are essential.

A rare subtype of renal cell carcinoma (RCC) is Bellini collecting duct carcinoma, also known as medullary renal carcinoma or distal nephron carcinoma, which accounts for 0.4-2.0% of all RCC cases. This subtype has the poorest prognosis of all RCC subtypes, typically presenting as a low-grade tumor at the pT3 or higher stage. Consequently, many patients have distant metastases at diagnosis and 60% develop metastases following radical treatment. There have been approximately 400 literature-reported cases of Bellini ductal carcinoma to date. We present a case report of a patient with early-stage Bellini duct cancer and a literature review of published reports on this condition.

Russian Society of Cardiology (RSC)With the participation of: the National Society for the Study of Atherosclerosis (NOA), the Atherothrombosis National Society, the Russian Association of Cardiovascular Surgeons, the Russian Society of Cardiosomatic Rehabilitation and Secondary Prevention (RosOKR), the Russian Society of Radiologists and Radiologists (RSRR), the Russian Association of Ultrasound Diagnostics Specialists in Medicine (RASUDM), the Russian Scientific Society for X-ray Endovascular Diagnosis and Treatment

In recent years, the frequency of contrast-enhanced radiological studies has increased significantly, and the issues of their selection and rational use do not lose their relevance. These methodological recommendations represent a complete up-to-date guide for using contrast agents (CA) in radiology. Types of currently used CA in computed tomography, magnetic resonance imaging, and ultrasound examinations are described. Safety rules for injection of each CA type are systematized, the principles of dosing and possible side effects are explained. In addition, it is important to highlight the issues of interactions between CA and other drugs that patient might take, in particular, the possible deterioration of renal function when using CA in diabetes mellitus patients taking metformin. It should be noted that these recommendations have undergone significant changes in recent years. Also questionnaire templates for patients prior to the contrast-enhanced study are given in the supplements. The methodological guidelines are based on current publications of international experts on CA use in radiology as well as on the data of two major guidelines: American College of Radiologists (ACR) Guidelines (2023) and European Society of Urogenital Radiology (ESUR) Safety Recommendations (2018, version 10). Thus, the information presented is validated, which provides grounds for its application in real clinical practice. The guidelines will be actualized as new scientific evidence becomes available, but to date they appear to be the most relevant.

BACKGROUND: Liver function assessment is very important in clinical practice. The use of magnetic resonance imaging for the anatomical and functional evaluation of the liver is possible in actual clinical practice. AIM: To examine the possibility of using hepatobiliary contrast-enhanced magnetic resonance imaging for the evaluation of liver function. MATERIALS AND METHODS: Datasets of patients who underwent gadoxetic acid-enhanced magnetic resonance imaging were retrospectively reviewed. Patients were divided into two groups: group 1 included patients with impaired liver function, and group 2 included those with normal liver function. Based on magnetic resonance imaging in the hepatobiliary phase, the liver parenchyma signal intensity and its ratio to spleen signal intensity and portal vein signal intensity were estimated. Differences among these parameters were compared between groups. The correlation between liver parenchyma signal intensity and laboratory blood tests reflecting liver function (total bilirubin, albumen, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma glutamyl transpeptidase, and prothrombin time) were analyzed. RESULTS: Datasets of 53 patients (25 men and 28 women, aged 24–84 years) were analyzed. Group 1 included 19 patients, whereas group 2 included 34. The median liver parenchyma signal intensity was 919.05 [669.65; 1258.35] in group 1 and 1525.13 [1460.5; 1631.4] in group 2 (p=0.0000001). The median ratio of liver parenchyma signal intensity to spleen signal intensity was 1.2 [1.04;1.7] in group 1 and 1.7 [1.46; 1.96] in group 2 (p=0.00076). The median ratio of liver parenchyma signal intensity to portal vein signal intensity was 1.44 [1.29; 1.83] in group 1 and 1.6 [1.43; 1.83] in group 2 (p=0.1). The estimated correlation values between liver parenchyma signal intensity and blood tests parameters were as follows: total bilirubin (r=–0.61; p=0.000001), albumen (r=0.13; p=0.61), aspartate aminotransferase (r=–0.57; p=0.000009), alanine aminotransferase (r=–0.44; p=0.001), alkaline phosphatase (r=–0.45; p=0.0007), gamma glutamyl transpeptidase (r=–0.5; p=0.0003), prothrombin time (r=–0.34; p=0.04). CONCLUSION: The study reflects the ability to assess liver function using indices (liver parenchyma signal intensity and its ratio to spleen signal intensity) derived from gadoxetic acid-enhanced magnetic resonance imaging. However, this study did not confirm the assumed effectiveness of using the liver parenchyma signal intensity to portal vein signal intensity ratio as an index of liver function. A significant inverse correlation was identified between liver parenchyma signal intensity and blood test parameters in reflecting liver function, except for albumin. The results indicate the possibility of using magnetic resonance imaging to assess liver function.