Purpose: Few in vivo studies have been reported describing efficacy and duration of antibiotic lock therapy (ALT) with daptomycin (DPT) for long-term catheter-related bloodstream infections (CRBSI) due to coagulase-negative staphylococci (CoNS). We retrospectively analysed the efficacy of short-course ALT with DPT in combination with systemic treatment (ST) for CoNS-associated CRBSI in our hospital. Methods: Patients admitted for CoNS-associated CRBSI and treated with DPT as ALT and ST were retrospectively analysed. Success was defined as preservation of the catheter device 30 days after ending treatment. Catheter removal within 30 days of discontinuing treatment, for either microbiological documentation of CRBSI relapse or re-occurrence of unexplained fever, was considered as failure. Results: Among 7610 patients admitted to the Departments of Internal Medicine/Infectious Diseases and Pneumology in Cannes from January 2013 to November 2015, we identified 28 episodes of CoNS-associated CRBSI. Seven patients died of cancer during follow-up. Thus, 21 episodes were analysed among 20 patients (median age 67 years, 12 males, all treated for neoplasia and carrying a port-a-cath® device). Staphylococcus epidermidis was the main agent responsible for CRBSI. Median duration of systemic and ALT DPT was 3 days, in combination with rifampin for 4 days and then generally followed by a switch to oral drugs, most frequently cotrimoxazole or linezolid, to achieve 14 median days of treatment. Clinical success and failure rates were 76% and 24%, respectively. Conclusions: Short-course DPT as ALT, combined with 14 days of ST, allowed conservative management of CoNS-associated CRBSI in surgically implanted-catheters in three-fourth of cases.

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

The chiral ligands, 4,4'-bis{(1S,2R,4S)-(-)-bornyloxy)-2,2'-bipyridine, (1S,2R,4S)-1, and 4,4'-bis{(1R,2S,4R)-(+)-bornyloxy)-2,2'-bipyridine, (1R,2S,4R)-1, have been prepared and characterized by spectroscopic techniques and, for (1S,2R,4S)-1, by single crystal X-ray diffraction. Despite the use of enantiomerically pure ligands, the formation of the complexes [Fe((1S,2R,4S)-1)(3)](2+), [Ru((1S,2R,4S)-1)(3)](2+), [Ru((1S,2R,4S)-1)(bpy)(2)](2+) and [Ru((1R,2S,4R)-1)(bpy)(2)](2+) proceeds without preference for either the Delta or Lambda-diastereoisomers. (C) 2007 Elsevier Ltd. All rights reserved.

Question of the study: We studied whether prophylactic use of noninvasive pressure support ventilation (NIPSV) administered pre- and postoperatively may reduce the postoperative pulmonary function impairment.Patients and methods: Prospective randomized clinical trial. Thirty-nine patients with a preoperative FEV1 <70% of the predicted value scheduled for elective lobectomy related to lung cancer were enrolled. Seven patients were excluded after enrollment. Patients were required to follow standard treatment without (control group, n = 18) or with NIPSV (study group, n = 14) during 7 days at home before surgery, and during 3 days postoperatively. Primary outcome variable was the changes on arterial blood gases on room air.Results: Two hours after surgery, PaO2, FVC and FEV1 values were significantly better in the NIPSV group. On day 1, 2 and 3, PaO2 was significantly improved in the NIPSV group. Also on day 1, FVC and FEV1 improved significantly in the NIPSV group. The hospital stay was significantly longer in the control group than in the study group (p = 0.04). The incidence of major atelectasis was 14.2% in the NIPSV group and 38.9% in the no-NIPSV group (p = 0.15).Answer to the question: Prophylactic use of NIPSV in a pre- and postoperative manner significantly reduces pulmonary dysfunction after lung resection. As a result, recovery of preoperative respiratory function is accelerated. (C) 2006 Elsevier Ltd. All rights reserved.

H-1 NMR spectra reveal the presence of 1: 1 complexes of cobalt(II) and tpy (tpy = 2,2':6,2"-terpyridine) in solution and a solid-state structural determination of Co(tpy)(OAc)(2)center dot 0.5H(2)O reveals the presence of hydrogen-bonded dinuclear units with both mono- and bidentate acetate ligands. (C) 2006 Elsevier B.V. All rights reserved.

Rituximab is indicated for the treatment of low-grade lymphoma. Pulmonary toxicity related to rituximab is exceptional.Here we report a patient with non-Hodgkin lymphoma treated with "CHOP" chemotherapy (cyclophosphosphamide, adriamycin, vincristine and prednisolone) and rituximab who developed an interstitial pneumonia with acute respiratory failure. The differential diagnosis of this clinical and radiological diagnosis is discussed.Although cases of interstitial pneumonia associated with rituximab are rare, they may be severe and thus any patient experiencing respiratory symptoms on this therapy should be monitored closely.

Upon functionalisation of 1,7-diaza-4,10-dioxacyclododecane 2 on both nitrogen atoms by two pyridine units using the para-position with respect to the nitrogen of the pyridine, the bismonodentate ligand 1 was obtained and structurally characterised in the solid state by X-ray diffraction on single-crystal. Under self-assembly condition, in the presence of AgPF6, the above mentioned ligand 1 forms the macrotricyclic metallamacrocycle 4 composed of two ligands and two silver cations with linear coordination of both metal cations. The barrel type structure thus obtained was also characterised in the solid state by X-ray diffraction methods.

Based on the coordination ability of ClO4-, BF4- and Cl- anions, a switch from discrete octahedral Co(II) complexes to a directional 1-D network was demonstrated using organic tectons based on a pyridine unit as a monodentate coordination site and a terpyridine moiety as a tridentate coordination pole; whereas with non-coordinating anions discrete mononuclear complexes were obtained, for Cl- anion a 1-D coordination network was obtained in the presence of CoCl2 under self-assembly conditions; the X-ray study on a single crystal revealed the centrosymmetric packing of the 1-D networks.