Mixed ligand copper(II) complexes of dicyanamide with different polyamines, viz. ethylenediamine (1) and 1,3-diaminopropane (2), have been synthesized and characterized. The crystal structure of complex 1 contains a five-coordinated copper in a distorted square-pyramidal environment and forms 1D zig-zag polymeric chain via the bridging ligand dicyanamide. Hydrogen bonding contributes supramolecular architecture in the crystal. Electronic spectral studies suggest the distorted square-pyramidal structure of the complexes. The interaction of the copper(II) complexes with calf-thymus DNA reveals nonintercalative binding mode. The two complexes have antimicrobial activity against the bacteria (viz. Salmonella paratyphi), which is responsible for paratyphoid fever.

Tri-phenyltin(IV) complexes of some azo-imino-para-carboxylates have been synthesized by reacting para-azobenzoic acid ligand, i.e. 4-(3-formy1-4-hydroxy-phenylazo)-benzoic acid with triphenyltin(IV) hydroxide in anhydrous toluene and then condensed with appropriate aniline derivatives in absolute ethanol. The complexes have been characterized by elemental analysis, UV, IR, H-1, C-13 and Sn-119 NMR spectroscopy. Sn-119 NMR values for all the complexes fall within the range specified for 4-coordinate geometry indicating that the complexes have four-coordinate tetrahedral structures around tin atom in solution. The complexes were screened for their in vitro antimicrobial activities against various microbes and compared with standard drugs. All the tested tri-phenyltin(IV) complexes were found to exhibit effective antimicrobial activity.

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Tri-n-butyltin(IV) complexes of 4-{(E)-4-hydroxy-3-[(E)-(aryl) iminomethyl] phenyl diazenyl} -benzoic acids (L1-4HH') and 4-((E)-(3-((E)-(2,4-dinitrophenyl) hydrazono) methyl)-4-hydroxy-phenyl) diazenyl) benzoic acid ((LHH)-H-5') have been synthesized by reacting 4-[(E)-2-(3-formyl-4-hydroxy-phenyl)-1-diazenyl] benzoic acid (LHH') with bis-tri-n-butyltin(IV) oxide in anhydrous toluene, and then condensed with appropriate substituted anilines and 2,4-DNP (2,4-dinitro phenyl hydrazine) in ethanol. The complexes 1-5, have been characterized by UV, IR, H-1-, C-13-, Sn-119-NMR spectroscopy in combination with elemental analysis. The elemental analysis and spectroscopic studies of the complexes are consistent with the constitution of the expected products and suggested tetrahedral geometries in solution. The in vitro antimicrobial activities of the compounds were evaluated against various microbes and compared with standard drugs. The compounds were found to possess effective antimicrobial activity against the screened microbes.

This study was carried out to determine the contents of total phenol as well as antioxidant activity, the chemical composition and anti-dermatophytic activity of the Vitex trifolia (Family: Lamiaceae) essential oil of the leaves. Hydro-distillation of the V. trifolia was carried out using Clavenger Vendor to obtain the volatile oil. Total phenolic content and antioxidant activity were determined using the Folin-Ciocalteau reagent and DPPH radical scavenging assay test by spectrophotometric methods. Gas chromatography- mass spectrometric (GC-MS) analyses (BP - 1 chrompack capillary column) of the essential oil was performed and its composition determined. The in-vitro anti-dermatophytic activity was evaluated both by agar diffusion and microbroth dilution methods against Candida albicans ATCC 90029, C. albicans ATCC 1162, C. albicans ATCC Y-9-19, C. parapsilosis ATCC 20019, C. glabrata ATTC 91030, C. krusei ATCC 6258, C. krusei ATCC 71061-1113 and C. kefyr ATCC 1110. The fresh leaves were yielded 0.21% of yellowish colour essential oil. By GC-MS analysis of the essential oil, 50 constituents were identified. 1R-α-pinene, Ocimene, 3-carene, Toluene, p-ethyl-, Eucalyptol and 3-methoxy-5-methylphenol were the major constituents. The V. trifolia contained appreciable levels of amount of total phenolic content (74.66μg GAE/100mg) of the fresh weight and the DPPH free radical scavenging activity (the IC50 = 5.2 μg/ml). The anti-dermatophytic activity showed that essential oil had some antifungal activity on the tested Candida in the concentration 500 μg/ml. The highest antifungal activity was C. krusei ATCC 6258 and C. kefyr ATCC 1110 (zone diameter 27.97±0.4 mm and 23.88±0.8 mm) respectively and C. krusei ATCC 6258 (MIC = 1.953125 μl/ml).

Three new [Cu-2(mu-Cl)(2)(O-2-alkoxyethylpyridine-2-carboximidate)(2)Cl-2] complexes, where alkoxy = methoxy, ethoxy, and butoxy, were synthesized and characterized by elemental analyses, FTIR spectra, electronic spectra, EPR, conductance, magnetic moment, powdered X-ray powder diffraction, and X-ray single-crystal diffraction. The three complexes contain chloride as a bridging ligand and in each complex the planar bidentate ligand binds the metal ion via the pyridine-N and the NH of the imino ether group. The X-ray crystal structure of [Cu-2(mu-Cl)(2)(O-2-butoxyethylpyridine-2-carboximidate)(2)Cl-2] shows that it crystallizes as a centrosymmetric dinuclear species in which each copper(II) is in a distorted square pyramid. Magnetic field-induced partial molecular alignment has been observed in polycrystalline samples of 2 and 3 when cooled in a magnetic field of 1 T at 77 K. The interaction of these complexes with Calf thymus DNA has been explored and the values of binding constant, K-b for 1, 2, and 3 are 1.524 x 10(3), 5.587 x 10(3), and 6.362 x 10(3) (ML-1)(-1), respectively. Complexes were screened for antimicrobial activities by the agar well diffusion technique.

Sulphonamide compounds (1-4) were synthesized by simple condensation of sulphanilamide with carbonyl derivatives. The compounds were characterized by elemental analysis, IR, H-1 and C-13 NMR spectroscopy. All the carbonyl derivatives form Schiff base compounds (2-4) with sulphanilamide while with acetylacetone; the Schiff base compound formed undergoes keto-enol tautomer and then crystallized as 4-(4-oxopent-2-en-2-ylamino)benzene sulfonamide compound (1) in which azomethine nitrogen atom is protonated. The H-1 and C-13 NMR spectroscopy data indicates the formation of the compounds and reveals the protonation of azomethine nitrogen atom in compound 1 which has also been confirmed by X-ray crystal structure. All the compounds were screened for antibacterial and antifungal activities against different microbes. Compound 1 and 2 were found to be effective antifungal agents against C. albicans while 3 and 4 shown antibacterial activities against Escherichia coli and Salmonella paratyphi. The minimum inhibition concentration of all the compounds were also determined and compared with standard drugs.

A new series of Schiff base derived from isonicotinic acid hydrazide [INH] and pyridine-2-carbaxaldehyde [py-2-yl] transition metal complexes have been synthesized and characterized by elemental analysis, infrared, electronic spectra, thermal analyses, and magnetic susceptibility measurements. From the data obtained the molecular formula of the complexes were proposed as [M(II)((N′-(pyridin-2-yl) methylene) nicotino hydrazide)2] where M = Mn(II), Co(II), Ni(II) and Cu(II). All the complexes were found to be octahedral geometry where the Schiff base ligand act as a tridentate ligand. Antimicrobial activity against several microbes have been tested and found Co(II), Ni(II) and Cu(II) complexes exhibited potent antibacterial activity with the reference standard ciprofloxacin.