Anti-muscarinic type 3 receptor (M3R) autoantibodies are significantly associated with the pathogenesis of Sjögren’s syndrome (SjS). It is established that activation of M3R with acetylcholine plays a pivotal role in the induction of glandular fluid secretions. However, the pathogenic roles of anti-M3R autoantibodies in the context of gland tissue destruction and/or salivary hyposecretion remain unclear. Based on that, it was hypothesized that anti-M3R monoclonal autoantibody could induce salivary hyposecretion, as well as gland tissue destruction, in normal BALB/c strain mice with no genetically predisposing autoimmune condition.

Objectives. Chronic orofacial pain (OFP) is common worldwide, adversely influences quality of life, and imposes substantial health care costs. Thus, our objective was to test the efficacy of recombinant herpes simplex virus (HSV)-based gene transfer for the alleviation of inflammatory OFP.

Exponential growth of self-amplified spontaneous emission at 530nm was first experimentally observed at the Advanced Photon Source low-energy undulator test line in December 1999. Since then, further detailed measurements and analysis of the results have been made. Here, we present the measurements and compare these with calculations based on measured electron beam properties and theoretical expectations.

Sixty-seven authentic isolates, representing six species fromFusariumsectionFusarium(= section Discolor) were subjected to random amplified polymorphic DNA (RAPD) analysis and polymerase chain reaction using species-specific primers. Remarkably uniform RAPD banding patterns were obtained intraspecifically, irrespective of the geographical origin of the isolates or the host/substratum from which they were isolated. Isolates were also assessed for colony characteristics when grown on a defined minimal medium. The Quorn strain (ATCC 20334; previously considered to beF. graminearum) matched theF. venenatumstrains exclusively in RAPD profile. In addition, equivalently sized DNA fragments amplified from ATCC 20334 and two authenticF. venenatumstrains were identical with respect to DNA sequence. Our molecular and morphological data support the identification of the Quorn strain asF. venenatumNirenberg (=F. sambucinumFuckelsensu lato).