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1Juvenile Xanthogranuloma with Inconspicuous Foam Cells and Giant Cells.

WS TANZ,YA KIM,RA SCHWARTZ,T WALTERS,CK JANNIGER,WC LAMBERT

International Journal of DermatologyVolume 34, Issue 9 p. 653-655 JUVENILE XANTHOGRANULOMA WITH INCONSPICUOUS FOAM CELLS AND GIANT CELLS WARREN S. TANZ M.D., WARREN S. TANZ M.D. From Dermatology, Pathology, and Pediatrics, New Jersey Medical School, Newark, New Jersey.Search for more papers by this authorY. ALYSSA KIM M.D., Y. ALYSSA KIM M.D. From Dermatology, Pathology, and Pediatrics, New Jersey Medical School, Newark, New Jersey.Search for more papers by this authorROBERT A. SCHWARTZ M.D., M.P.H., Corresponding Author ROBERT A. SCHWARTZ M.D., M.P.H. From Dermatology, Pathology, and Pediatrics, New Jersey Medical School, Newark, New Jersey.Address for correspondence: Robert A. Schwartz, M.D., Department of Dermatology, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103.Search for more papers by this authorTHOMAS WALTERS M.D., THOMAS WALTERS M.D. From Dermatology, Pathology, and Pediatrics, New Jersey Medical School, Newark, New Jersey.Search for more papers by this authorCAMILA K. JANNIGER M.D., CAMILA K. JANNIGER M.D. From Dermatology, Pathology, and Pediatrics, New Jersey Medical School, Newark, New Jersey.Search for more papers by this authorW. CLARK LAMBERT M.D., PH.D., W. CLARK LAMBERT M.D., PH.D. From Dermatology, Pathology, and Pediatrics, New Jersey Medical School, Newark, New Jersey.Search for more papers by this author WARREN S. TANZ M.D., WARREN S. TANZ M.D. From Dermatology, Pathology, and Pediatrics, New Jersey Medical School, Newark, New Jersey.Search for more papers by this authorY. ALYSSA KIM M.D., Y. ALYSSA KIM M.D. From Dermatology, Pathology, and Pediatrics, New Jersey Medical School, Newark, New Jersey.Search for more papers by this authorROBERT A. SCHWARTZ M.D., M.P.H., Corresponding Author ROBERT A. SCHWARTZ M.D., M.P.H. From Dermatology, Pathology, and Pediatrics, New Jersey Medical School, Newark, New Jersey.Address for correspondence: Robert A. Schwartz, M.D., Department of Dermatology, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103.Search for more papers by this authorTHOMAS WALTERS M.D., THOMAS WALTERS M.D. From Dermatology, Pathology, and Pediatrics, New Jersey Medical School, Newark, New Jersey.Search for more papers by this authorCAMILA K. JANNIGER M.D., CAMILA K. JANNIGER M.D. From Dermatology, Pathology, and Pediatrics, New Jersey Medical School, Newark, New Jersey.Search for more papers by this authorW. CLARK LAMBERT M.D., PH.D., W. CLARK LAMBERT M.D., PH.D. From Dermatology, Pathology, and Pediatrics, New Jersey Medical School, Newark, New Jersey.Search for more papers by this author First published: September 1995 https://doi.org/10.1111/j.1365-4362.1995.tb01104.xCitations: 8 Presented in part at the American Society of Dermatopathology 29th Annual Meeting, Dallas, Texas, December 4–6, 1991, and at the 18th World Congress of Dermatology, New York City, June 12–18, 1992. It was published in abstract form: J Cutan Pathol 1991; 18:375, and in the Congress Proceedings. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Helwig KB, Hackney VC. Juvenile xanthogranuloma (nevoxanthoendothelioma). Am J Pathol 1954; 30: 625–626. 2 Sonada T, Hashimoto H, Enjoji M. Juvenile xanthogranuloma: clinicopathologic analysis and immunohis-tochemical study of 57 patients. Cancer 1985; 56: 2280–2286. 3 Rodriguez J, Ackerman AB. Xanthogranuloma in adults. Arch Dermatol 1976; 112: 43–44. 4 Gianotti F, Caputo R. Histiocytic syndromes: a review. J Am Acad Dermatol 1985; 13: 383–404. 5 Zelger B, Cerio R, Orchard G, Wilson-Jones E. Juvenile and adult xanthogranuloma: a histological and immunohistochemical comparison. Am J Surg Pathol 1994; 18: 126–135. 6 Garvey WT, Grundy SM, Eckel R. Xanthogranulomatosis in an adult: lipid analysis of xanthomas and plasma. J Am Acad Dermatol 1987; 16: 183–187. 7 Gianotti F. Cutaneous prolitcrative histiocytosis in children. G ltal Dermatol Venereol 1980; 117: 59–66. 8 Gianotti F, Zina G. Xanthogranulomatoses juveniles: XIIIe Congres de I'Association des Dermatologistes et Sypliligraphes de Langue F'rancaise, Turin, 1969. Paris, 1971. Masson et Cie Editeurs, pp 103–138. 9 Guinnepin MT, Puissant A. Juvenile xanthogranuloma: G ltal Dermatol Venereol 1980; 115: 101–105. 10 Morier P, Mérot Y, Paccaud D, et al. Juvenile chronic granulocytic leukemia, juvenile xanthogranulomas, and neurofibromatosis. J Am Acad Dermatol 1990; 22: 962–965. 11 Ackerman AB. Histologic diagnosis of inflammatory skin diseases. Philadelphia : Lea & Febiger, 1978: 470. 12 Lattes R. Tumors of the soft tissues (revised): Washington , DC : Armed Forces Institute of Pathology, 1982: 50. 13 Aterman K, Remmele W, Smith M. Karl Touton and his “Xanthelasmatic Giant Cell. Am J Dermatopathol 1988; 10: 257–269. 14 Muffarij NA, Muallem MM, Kibbi A-G, et al. Multiple papules in a child. Arch Dermatol 1989; 125: 1703–1708. 15 Shapiro PE, Silvers DN, Treiber RK, et al. Juvenile xanthogranulomas with inconspicuous or absent foam cells and giant cells. J Am Acad Dermatol 1991; 24: 1005–1009. 16 Gartmann H, Tritsch H. Klein- und grossknotiges Naevoxantlioendotheliom. Arch Klin Exp Dermatol 1963; 215: 409–421. 17 Tahan SR, Pastel-Levy C, Bhan AK, et al. Juvenile xanthogranuloma: clinical and pathologic characterization. Arch Pathol Lab Med 1989; 113: 1057–1061. 18 Esterly NB, Sahihi T, Medenica M. Juvenile xanthogranuloma. Arch Dermatol 1972; 105: 99–102. 19 Nomland R. Nevoxantho-endothelioma. J Invest Dermatol 1954; 22: 207–215. 20 Montgomery H. Dermatopathology. New York : Harper and Row, 1967: 803. 21 Dahl I, Angervall L. Pseudosarcomatous lesions of the soft tissues reported as sarcoma during a 6–year period (1958–1963). Acta Path Microbiol Scand [A] 1977; 85: 917–930. 22 Enzinger FM, Weiss SW. Soft tissue tumors. St. Louis : Mosby-Year Book, 1988: 233. 23 Lever WF, Sehaumburg-Lever G. Histopathology of the skin. Philadelphia : JB Lippincott, 1983: 298. 24 Nodl F. Systematisierte grossknotige Naevoxanthoen-dotheliome. Arch Klin Exp Dermatol 1959; 208: 601–615. 25 Berson SD, Issfoff SW, Kotten B, et al. Juvenile xanthogranuloma. S Afr Med J 1972; 46: 565–568. 26 Winkelmann RK. Cutaneous syndromes of non-X-histiocytosis: a review of the macrophage-histiocyte diseases of the skin. Arch Dermatol 1981; 117: 667–672. 27 Cohen BA, Hood A. Xanthogranuloma: report on clinical and histiologic findings in 64 patients. Pediatr Dermatol 1989; 6: 262–266. 28 Kim YA, Walters T, Schwartz RA, et al. Juvenile xanthogranuloma with inconspicuous foam cells and giant cells with immunoperoxidase stains and electron microscopy studies. J Cutan Pathol 1991; 18: 375. [Abstr]. 29 Claudy AL, Misery L, Serre D, Boucheron S. Multiple juvenile xanthogranulomas without foam cells and giant cells. Pediatr Dermatol 1993; 10: 61–63. 30 Schwartz RA, Janniger CK, Hashimoto K, Lambert WC. Congenital self-healing Langerhans cell histiocytosis. In: DJ Dennis, ed. Clinical dermatology. Philadelphia : JB Lippincott, 1992:Unit 20–16A, pp 1–9. 31 Gown AM, Tsukada T, Ross R. Human atherosclerosis. II. Immunocytochemical analysis of the cellular composition of human atherosclerotic lesions. Am J Pathol 1986; 125: 191–207. Citing Literature Volume34, Issue9September 1995Pages 653-655 ReferencesRelatedInformation

1995International Journal of Dermatology（1995）引用：15

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2Juvenile xanthogranuloma.

W S Tanz, R A Schwartz,C K Janniger

1994Cutis（1994）引用：22

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3DAMAGE-RESISTANT DNA-SYNTHESIS IN XERODERMA-PIGMENTOSUM CELLS - REVERSAL FOLLOWING ELECTROPORATION OF NORMAL CHROMATIN-ASSOCIATED ENDONUCLEASES

WC LAMBERT,GJ TSONGALIS,WS TANZ,MW LAMBERT

1990JOURNAL OF INVESTIGATIVE DERMATOLOGY（1990）

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4ADDITIONAL ABNORMALITIES IN XERODERMA PIGMENTOSUM AND OTHER REPAIR-DEFICIENT HUMAN CELL-LINES ARE DETECTED BY A NEW ASSAY FOR DNA-REPAIR IN CULTURE

WC LAMBERT,MW LAMBERT,WS TANZ

1989JOURNAL OF INVESTIGATIVE DERMATOLOGY（1989）

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5Defective-Dna Synthesis and or Repair in Amyotrophic-Lateral-Sclerosis

WC LAMBERT,WS TANZ,GJ TSONGALIS,AO OKORODUDU

1989DNA REPAIR MECHANISMS AND THEIR BIOLOGICAL IMPLICATIONS IN MAMMALIAN CELLS引用：2

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6Further Studies on Selection for Viable Cells in Culture Using Cell Sorter Technology

WS TANZ,GJ TSONGALIS,WC LAMBERT

The authors have developed a two-channel method, using forward and lateral light scatter, for selecting live and nonviable cultured lymphoblastoid cells without exposing the cells to any dye. These parameters are related to cell size and cell granularity, both of which are quickly altered in cells which become nonviable as determined by dye exclusion (0.1% trypan blue). Using the nontoxic vital dye, fluorescein diacetate, the authors have also developed a system which only requires a single channel to unequivocally separate live and nonviable lymphoblastoid cells in culture.<>

1988Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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7Human Splenic Fc Receptor Function and Dysfunction: Definition by Circulatory Clearance Rate Compared to Computerized Kinetic Scintigraphy

RY LIN,SP RACIS,E HIGGINBOTHAMFORD,WS TANZ

In vivo reticuloendothelial Fc receptor function was studied in 14 individuals. To assess this function Tc-99m-labeled IgG-coated autologous erythrocytes were injected intravenously and circulatory clearance rates of radioactivity were determined. In 12 individuals [6 normals and 6 patients with systemic lupus erythematosus (SLE)], kinetic computerized scintigraphic imaging of various internal organs was compared to circulatory clearance rates. Both circulatory clearance rates and percentage splenic uptake (PSU) were significantly depressed in patients. The difference between patients and normals was more significant for PSU than for circulatory clearance. Splenic uptake curves showed significantly less linearity for patients, suggesting that splenic defects in SLE are not only quantitative, but also are qualitative. Understanding the nature of immune clearance defects in immune complex mediated diseases may allow for a more rational approach to treatment of patients with these disorders.

1986INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY（1986）引用：6

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8Suppressor Function of T Lymphocytes in the Acquired Immunodeficiency Syndrome As Assessed by Allogeneic Mixed Lymphocyte Culture.

RY LIN,WS TANZ,TN DENNY

Nine patients with the acquired immunodeficiency syndrome (AIDS) were studied for suppressor cell activity utilizing an allogeneic mixed lymphocyte culture technique. The patients studied had opportunistic infections and a high incidence of intravenous drug abuse. T lymphocytes of the AIDS patients showed a consistently greater ability to suppress immunoglobulin M (IgM) synthesis by pokeweed mitogen stimulated allogeneic lymphocytes compared to controls (p less than 0.03). In 4 patients, T helper function was studied and compared to controls. Diminished helper cell function was consistently observed (p less than 0.01). All AIDS patients had leu 3a/leu 2a ratios of less than 0.9. However, a statistical correlation between the helper/suppressor cell ratio and suppressor activity was not demonstrated. Functional tests of T lymphocytes may be of value in assessing immunocompetence in patients with altered lymphocyte subset ratios.

1985PubMed（1985）引用：26

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9Technicium As A Radiolabel in the Assessment of Invivo Human Fc Clearance

R Y Lin,W S Tanz,S P Racis, M Feldman, J Torine, K M Barry

99m-Tc was used as a radiolabel to study in vivo human clearance of IgG sensitized erythrocytes. Stannous chloride pretreatment at different doses and varying amounts of 99m-Tc were studied with respect to radiolabelling efficiency and elution. Mean in vivo clearance rates in systemic lupus erythematosus patients were significantly prolonged compared to controls. Using as little as 200 microCi of 99m-Tc per patient, in vivo human immune clearance can be determined with a minimal radiation biohazard. With this method, serial immune determinations can be performed within very short time frames, allowing for monitoring effects of immunomodulatory therapy as well as variations in disease activity.

1985Journal of clinical & laboratory immunology（1985）引用：23

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