Objective:To explore the medication rules and mechanism of traditional Chinese medicine（TCM） in treating patients with advanced gastric cancer through data mining technology combined with network pharmacology and gene chip technology. Methods:Medical records of 135 patients with advanced gastric cancer who benefited from TCM treatment were collected, core drug combinations were obtained by data mining technology, common targets of drugs and diseases were obtained by network pharmacology combined with gene chip technology, and relevant mechanisms of action were explored. The expression of key targets in gastric cancer and their relationship with the survival of gastric cancer were explored through Oncomine and Kaplan-Meier Plotter databases. Results:Among the 135 patients who benefited from the treatment of advanced gastric cancer,there were 81 males and 54 females, with an average age of 59.33 years. The drug frequency from high to low mainly included Huangqi（Astragalus）, Dangshen（Codonopsis）, Banxia（Pinellia）, Chenpi（Tangerine Peel）, Fuling（Poria）, and so on. The four Qi were mainly warm, flat and cold, and the five flavors were mainly sweet, bitter and pungent. The main meridian was the spleen meridian. "Huangqi（Astragalus）-Dangshen（Codonopsis）-Banxia（Pinellia）-Chenpi（Tangerine Peel）-Fuling（Poria）" was the core drug combination of 135 prescriptions, which had 77 effective active ingredients. Taking the gastric cancer samples of GSE63089 and GSE118916 datasets in GEO database as the research object, a total of 520 differential genes of gastric cancer were obtained, of which58 drugs shared common targets with gastric cancer. NTRK1, TP53, MCM2, CUL3, and CDK2 were key targets.It was found that there were significant differences in the expression of NTRK1, TP53, and MCM2 in gastric cancer and normal tissues through the Oncomine database（P＜0.05）. Through the Kaplan Meier Plotter database,it was found that the overall survival（OS） and first progression time（FP） in the high expression group of NTRK1, TP53, and MCM2 were lower than those in the low expression group, with statistically significant differences（P＜0.05）. Conclusions:The study found that the TCM prescription of advanced gastric cancer is mainly to strengthen the spleen and replenish Qi, regulate Qi and remove phlegm. The core prescription is "Huangqi（Astragalus）-Dangshen（Codonopsis）-Banxia（Pinellia）-Chenpi（Tangerine Peel）-Fuling（Poria）". It regulates key targets such as NTRK1, TP53, MCM2, CUL3, and CDK2 through active ingredients such as quercetin, isorhamnetin,kaempferol and luteolin to participate in the regulation of tumor cell cycle, inflammatory response and other processes,and plays an anti-gastric cancer role by regulating cell cycle and p53 signal pathway. NTRK1, TP53, and MCM2 are highly expressed in gastric cancer tissues. The higher the expression levels of the three, the shorter the survival time of gastric cancer patients.

李冬云教授认为,多发性骨髓瘤便秘的基本病机为正虚为本,毒瘀为标,虚实夹杂.治疗上注重整体,倡导中西医结合治疗.主张分期辨证论治,善用枳术丸临证加减,治疗前期应解毒祛瘀,顾护胃气;治疗中期应健运脾胃,以补开塞;治疗后期应滋补肝肾,增液行舟.巧用中医外治,控制并发症.同时注重日常调摄,调护情志.审证求机,组方用药,取得了较好的疗效.附验案1 则,加以佐证.