Purpose: Iodoform gauze is commonly used to treat patients with localized alveolitis; however, saliva can easily dilute the iodoform concentration. This study aimed to compare the efficacies of platelet-rich fibrin (PRF) and iodoform gauze in treating localized alveolitis.Methods: This prospective randomized controlled trial enrolled patients with localized alveolitis who received treatment at our hospital from January 2018 to July 2021. They were randomly assigned to the control (treated with iodoform gauze) or experimental (treated with PRF) groups. Treatment method was the predictor variable. The primary outcome variable was clinical efficacy, defined as symptom resolution 1 week after treatment. Secondary outcome variables included granulation tissue (GT) quantitative score, analgesic drug dosage, and pain score determined using a visual analog scale (VAS). Patient demographics were used as covariates. Data analysis was performed by carrying out the chi(2) and Mann-Whitney rank sum tests; P values <.05 indicated statistical significance.Results: This study included 60 patients, equally and randomly divided into the control and PRF groups (n = 30 each). There were no significant differences in demographic characteristics of patients between the 2 groups. One week after treatment, the PRF group showed a higher healing rate (93.3% vs 60.0%) and better GT quantitative score (3.13 +/- 0.63 vs 1.70 +/- 0.75) than the control group (P < .05). Moreover, the number of analgesic tablets consumed within 1 week postoperatively was lesser in the PRF group than in the control group (3.93 +/- 1.53 vs 9.67 +/- 3.16, P < .05). The PRF group exhibited significantly lower VAS pain scores than those of the control group on the 3rd day (1.10 +/- 1.03 vs 4.17 +/- 1.49) and 7th day (0.30 +/- 0.60 vs 1.73 +/- 1.44, P < .05) postoperatively.Conclusions: Compared with iodoform gauze, PRF is associated with higher healing rate, faster promotion of GT growth in the extraction socket, better relief of alveolar pain, and lower intake of analgesic drugs when treating localized alveolitis.(c) 2023 American Association of Oral and Maxillofacial SurgeonsJ Oral Maxillofac Surg 81:1155-1160, 2023

PURPOSE:Double-barrel vascularized fibula graft is one of the most common surgical techniques to augment or maintain the height of the neo-mandible. The purpose of this study was to investigate whether the gap completely disappeared and gap ossification ultimately achieved between the double barrels.METHODS:Six rabbits were used in the study. Each animal's tibia was vertically osteotomized at its midpoint, folded onto each other and fixed by mini-titanium plate, thus an animal model of "double barrel" was established. Specimens were obtained at 3 months and 6 months postoperatively, then the gap ossification between the double barrels was evaluated by radiography and histomorphology. Measurements of the gap width between the two tibial struts on X-ray films were performed 3 months after the operation at three sites: distal, middle and proximal site. Measurements were compared with those obtained immediately after operation using SPSS 19.0 software package.RESULTS:Three months after operation, radiography demonstrated that the gap between the double barrels gradually became vague. Histological study showed that irregular new woven bone formed in the gap between the two struts. There was significant difference in mean gap width at the distal and proximal site (P<0.05), but there was no significant difference at the middle site(P=0.552). Radiological and histological study showed cortical bone resorption in the contact area and two thin tubular bones fused into a thicker one 6 months postoperatively.CONCLUSIONS:The double-barrel tibia fixed with titanium microplate can fuse into a large, unique, continuous bone barrel.

近年来,我国儿童恶性肿瘤的发病率呈逐年上升趋势,尽管对儿童恶性肿瘤的研究大量增加,儿童恶性肿瘤的治疗取得了重大进展,但以手术和放化疗为主的肿瘤治疗手段仅能杀死肿瘤细胞,无法有效控制部分儿童肿瘤的复发、转移.越来越多的研究证据表明,肿瘤细胞黏附性的改变在恶性肿瘤中的发生发展中起关键作用.多种细胞黏附分子参与肿瘤细胞和细胞外细胞基质间相互作用,在肿瘤复发、侵袭、增殖和远处转移中发挥重要作用[1].

目的 评价腓骨折叠技术重建下颌骨的效果以及平行折叠的两段腓骨之间的愈合情况.方法 对11例采用腓骨折叠技术修复下颌骨缺损的患者进行随访,在曲面断层片上测量术后1个月和术后两年平行折叠的两段腓骨之间的间隙宽度,评价两段腓骨之间的愈合情况.结果 术后1个月远中、正中、近中两段腓骨之间间隙宽度分别为3.82±1.83mm、3.82±1.89mm、4.55±1.21mm,术后2年三位点测量结果分别为2.45±1.86mm、3.18±1.83mm、2.18±1.47mm,远中位点和近中位点间隙宽度差异有统计学意义(P＜0.05),正中位点间隙宽度无显著差别(P =0.089).结论 采用腓骨折叠技术修复下颌骨缺损后,靠近自身下颌骨的截骨断端处骨改建明显,两段腓骨之间的间隙逐渐缩小.

Objective To introduce a method of establishing an animal model of long tubular bone with vertical distraction osteogenesis in minipigs. Methods Six Bama minipigs were used in this study. On each side of the tibia of each animal,osteotomy and placement of tractor were conducted. After operation, vertical distraction was performed two times a day at the rate of 0. 4mm each time. The distraction was continuous for 20 days and the animals were sacrificed six months after operation. Bilateral tibial specimens were obtained. The width of the tibia was measured and histologial examination performed. Results The width of the distracted side of the tibia was much wider than that of the untracted side. In addition, histology showed that the osteogenesis was not continuous in the exposed side and continuous in the unexposed side because of intact of the periosteum. Conclusion An easy and reliable minipig model of long tubular bone with vertical distraction osteogenesis was established in this study.

OBJECTIVE To observe the influence of perioperative continuous application of LAS on swallowing pain after UPPP. METHODS Thirty ASA Ⅱ patients with OSAHS underwent UPPP were randomly divided into 2 groups. In GroupⅠ,patients were given a bolus dose of LAS 10 mg/kg 30 min before induction of anesthesia followed by infusion at a rate of 5mg/kg h during the operation. After operation,PCIA was initiated with a lockout interval of 15min,the contents were Tramadol 500mg plus LAS 3000mg diluted to 100ml normal saline,the velocity was 2ml/h; In Group Ⅱ,patients were given postoperative analgesia with Tramadol plus LAS. The VAS,drug consumption,delivery/demand(D/D) and adverse effects were evaluated at 0,2h,4h,6h,12h,24h after operation. RESULTS VAS in groupⅠwas significantly lower than that in groupⅡ within 12h(P0.05). D/D in groupⅠ was significantly higher than that in groupⅡ in the first 2h(P0.05). The required dosage of Tramadol plus LAS in groupⅠ was significantly less than that in groupⅡ (P0.05). CONCLUSION LAS may have preemptive analgesia effect.