Background: The aim of radical prostatectomy (RP) is the complete removal of the prostate gland with negative surgical margins. The presence of cancer at the surgical margin is associated with higher probability of disease progression. Current methods of intraoperative margin assessment are inaccurate or time-consuming. The study goal was to evaluate the ability of a novel device (Dune Medical Devices) to differentiate between cancer and BPH. Methods: A total of 49 patients undergoing RP in four medical centers between November 2007 and May 2008 were enrolled in this study. The device was applied to numerous intra- and extra-capsular sites of freshly excised RP specimens. Measurement sites were accurately marked and analyzed histologically. The ability of the device to differentiate between malignant and nonmalignant sites was assessed. Results: A total of 15 156 measurements from 45 patients were analyzed. Differentiation of the intra-capsular malignant sites from extra-capsular nonmalignant sites (bladder neck and apex regions) depends on the cancer feature size. Differentiation was achieved with sensitivity and specificity of 93.6 (95% confidence interval (CI): 88–98) and 94.1 (95% CI: 93–95), respectively, at feature sizes at or >0.8 mm in diameter. The device was able to discriminate between all intra-capsular malignant (with feature sizes down to a few cells) and nonmalignant measurement sites, with sensitivity and specificity of 80.8 (95% CI: 73–87) and 68.4 (95% CI: 67–69), respectively. Conclusions: First results from a radio-frequency near-field spectroscopy sensor look promising for differentiation between cancer and benign prostate tissue. The sensor’s dimensions (radius of ∼1 mm) and design enable use in open, laparoscopic and robotic RP to evaluate the surgical margins intraoperatively.

August 2006 marked the 10th anniversary of landmark legislation when Israel’s parliament passed the unique Patient’s Rights Law. This law underscores the importance of medical ethics in Israeli society. During a seminar at the Shaare Zedek School of Nursing, third-year students performed a qualitative research study investigating ethical issues arising in the field of nursing, and how nursing staff dealt with these issues in relation to the law. The research was conducted using semistructured questionnaires. The results showed that the staff participants knew the law, but did not differentiate between legal and ethical problems. The establishment of a framework for dealing with these issues would help to promote professional ethics, encourage broad-based agreements related to ethical decisions, reduce ethical conflict, and increase implementation of the law on patients’ rights.

You have accessJournal of Urology1 Apr 2008IS RADICAL NEPHRECTOMY INDICATED FOR POSITIVE SURGICAL MARGIN DURING NEPHRON SPARING SURGERY? Orit Raz, Sonia Mendlovic, Yaniv Shilo, Dan Leibovici, Judith Sandbank, Arie Lindner, and Amnon Zisman Orit RazOrit Raz More articles by this author , Sonia MendlovicSonia Mendlovic More articles by this author , Yaniv ShiloYaniv Shilo More articles by this author , Dan LeiboviciDan Leibovici More articles by this author , Judith SandbankJudith Sandbank More articles by this author , Arie LindnerArie Lindner More articles by this author , and Amnon ZismanAmnon Zisman More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(08)61405-6AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "IS RADICAL NEPHRECTOMY INDICATED FOR POSITIVE SURGICAL MARGIN DURING NEPHRON SPARING SURGERY?." The Journal of Urology, 179(4S), pp. 478–479 © 2008 by American Urological AssociationFiguresReferencesRelatedDetails Volume 179Issue 4SApril 2008Page: 478-479 Advertisement Copyright & Permissions© 2008 by American Urological AssociationMetricsAuthor Information Orit Raz More articles by this author Sonia Mendlovic More articles by this author Yaniv Shilo More articles by this author Dan Leibovici More articles by this author Judith Sandbank More articles by this author Arie Lindner More articles by this author Amnon Zisman More articles by this author Expand All Advertisement PDF downloadLoading ...