We present GLM-5V-Turbo, a step toward native foundation models for multimodal agents. As foundation models are increasingly deployed in real environments, agentic capability depends not only on language reasoning, but also on the ability to perceive, interpret, and act over heterogeneous contexts such as images, videos, webpages, documents, GUIs. GLM-5V-Turbo is built around this objective: multimodal perception is integrated as a core component of reasoning, planning, tool use, and execution, rather than as an auxiliary interface to a language model. This report summarizes the main improvements behind GLM-5V-Turbo across model design, multimodal training, reinforcement learning, toolchain expansion, and integration with agent frameworks. These developments lead to strong performance in multimodal coding, visual tool use, and framework-based agentic tasks, while preserving competitive text-only coding capability. More importantly, our development process offers practical insights for building multimodal agents, highlighting the central role of multimodal perception, hierarchical optimization, and reliable end-to-end verification.

Vision-Language-Action (VLA) models have emerged as a promising paradigm for end-to-end autonomous driving. However, existing VLAs' training relies heavily on text-centric visual question answering and chain-of-thought reasoning data, which emphasizes linguistic reasoning rather than action-grounded planning. As a result, the learned representations capture semantic knowledge but lack spatial dependencies crucial for reliable trajectory prediction. We propose DriveTeach-VLA, a framework that explicitly teaches VLAs what to see and where to look. Driving-aware Vision Distillation (DVD) injects driving-specific perceptual priors into the vision encoder, while 2D Trajectory-Guided Prompts (2D-TGP) provide spatial conditioning aligned with feasible driving trajectories. Together, they form a vision-guided learning pipeline: what to see (DVD pretraining) - where to look (TGP-guided SFT) - how to act (TGP-guided GRPO). DriveTeach-VLA achieves the state-of-the-art performance on NAVSIM and nuScenes. Our code is available at: https://github.com/ShivaTeam/DriveTeach-VLA.

Integrating high-dimensional multi-omics data is essential for uncovering the coordinated molecular mechanisms underlying cancer progression and improving survival prediction. DNA methylation and mRNA expression represent two tightly coupled regulatory layers; however, many existing approaches either model them independently or rely on linear assumptions that fail to capture the nonlinear cross-omics structure. Here, we propose MT-ADSCCA, a multitask adaptive deep sparse canonical correlation analysis framework that jointly learns correlated latent representations, selects interpretable multi-omics biomarkers, and supports downstream survival modeling. MT-ADSCCA embeds sparse CCA into a nonlinear encoder architecture and uses uncertainty-guided adaptive weighting to stabilize multi-objective training. The selected features were subsequently modeled using a BiLSTM-Cox survival network with genes ordered by chromosomal coordinates to capture local genomic dependencies. We evaluated MT-ADSCCA using event-stratified nested 10-fold cross-validation across three TCGA cohorts: breast invasive carcinoma (BRCA), glioma (GBMLGG), and pan-kidney carcinoma (KIPAN), including 485, 563, and 652 matched multi-omics samples, respectively. MT-ADSCCA achieved the highest concordance indices across all cohorts, outperforming six feature-selection baselines (DA, WGCNA, lmQCM, CCA, OSCCA, DeepCorrSurv) and four survival-model baselines (LASSO-Cox, RSF, MTLSA, DeepSurv). Kaplan-Meier analyses further confirmed a clear separation between the predicted high- and low-risk groups. The selected canonical features were enriched in biologically coherent functional categories, supporting the interpretability of the learned patterns. Together, these results demonstrate that MT-ADSCCA provides a robust and interpretable framework for multi-omics integration and cancer prognosis prediction.

This paper proposes a novel approach to address the challenge that pretrained VLA models often fail to effectively improve performance and reduce adaptation costs during standard supervised finetuning (SFT). Some advanced finetuning methods with auxiliary training objectives can improve performance and reduce the number of convergence steps. However, they typically incur significant computational overhead due to the additional losses from auxiliary objectives. To simultaneously achieve the enhanced capabilities of auxiliary training with the simplicity of standard SFT, we decouple the two objectives of auxiliary-objective SFT within the parameter space, namely, enhancing general capabilities and fitting task-specific action distributions. To deliver the goal, we only need to train the model to converge on a small-scale task set using two distinct training strategies, resulting in two finetuned models. The parameters' difference between the two models can then be interpreted as capability vectors provided by auxiliary objectives. These vectors are then merged with pretrained parameters to form a capability-enhanced meta model. Moreover, when standard SFT is augmented with a lightweight orthogonal regularization loss, the merged model attains performance comparable to auxiliary finetuned baselines with reduced computational overhead. Internal and external experiments demonstrate that our capability vectors (1) are effective and versatile across diverse models, (2) can generalize to novel environments and embodiments out of the box.

UI videos provide a natural input for generating interactive webpages, as they capture both webpage appearance and action-triggered state transitions. However, directly applying video-capable vision-language models to this task remains insufficient. Existing models typically rely on sparse sampling or compressed temporal representations, which may miss short action boundaries and break the state-action-state transitions needed to implement webpage behavior. We formulate UI video-to-code generation as executable state-transition recovery from interaction videos, and identify this failure mode as state-transition misalignment. We introduce Video2Code, an action-aware video-to-code approach for recovering executable UI state transitions. Rather than allocating the visual budget uniformly across the video, Video2Code first performs coarse video understanding to locate action-critical regions, then invokes a temporal clipping tool to revisit these regions at higher temporal resolution before generating HTML/CSS/JavaScript code. We instantiate Video2Code with action-aligned video-code supervision and evaluate it under both visual and functional criteria. Experiments show that Video2Code substantially strengthens the underlying open-source model for UI video-to-code generation, improving functional correctness over direct video observation, especially on dense multi-step interactions.

Spatio-temporal grounding in long videos requires precise temporal localization and robust object tracking conditioned on natural-language queries. While recent vision-language models (VLMs) show strong reasoning ability, directly applying frame-by-frame inference to long sequences is computationally expensive and unstable. We propose a practical pipeline that shifts from frame-level to second-level tracking and performs cross-second smoothing to preserve continuity while reducing sequence length. To improve reasoning supervision, we synthesize chain-of-thought style trajectories using advanced multimodal models for temporal localization and target selection, and replace generated spatio-temporal coordinates with ground-truth annotations to avoid noisy supervision. We further optimize the policy with reinforcement learning using a verifier based on t_IoU+mv_IoU. Experiments across multiple FPS settings show that our method achieves a strong trade-off between efficiency and localization quality.

Automated homework assessment depends not only on recognizing student answers, but also on accurately locating where each answer and each intermediate reasoning step appears in noisy, multi-page handwritten work. This paper addresses the missing evaluation setting of page-aware, two-level answer-region grounding: given a sequence of homework page images, a model must localize complete answer regions and their ordered step-level subregions. We introduce HG-Bench, a benchmark of 500 human-annotated K-12 homework samples curated from a 1,489,278-image source pool, with question-level and step-level boxes linked by a hierarchical containment constraint. HG-Bench is paired with a page-aware evaluation protocol that separately measures complete-answer localization (FA) and step-level decomposition (FSm), revealing whether models truly ground the spatial structure of student reasoning rather than merely parse visible text. Across frontier closed-source APIs and competitive open-weight VLMs, no zero-shot system exceeds 55.22

Multimodal Large Language Models (MLLMs) have shown remarkable success in comprehension tasks such as visual description and visual question answering. However, their direct application to embedding-based tasks like retrieval remains challenging due to the discrepancy between output formats and optimization objectives. Previous approaches often employ contrastive fine-tuning to adapt MLLMs for retrieval, but at the cost of losing their generative capabilities. We argue that both generative and embedding tasks fundamentally rely on shared cognitive mechanisms, specifically cross-modal representation alignment and contextual comprehension. To this end, we propose CREM (Compression-driven Representation Enhanced Model), with a unified framework that enhances multimodal representations for retrieval while preserving generative ability. Specifically, we introduce a compression-based prompt design with learnable chorus tokens to aggregate multimodal semantics and a compression-driven training strategy that integrates contrastive and generative objectives through compression-aware attention. Extensive experiments demonstrate that CREM achieves state-of-the-art retrieval performance on MMEB while maintaining strong generative performance on multiple comprehension benchmarks. Our findings highlight that generative supervision can further improve the representational quality of MLLMs under the proposed compression-driven paradigm.

Composed video retrieval presents a complex challenge: retrieving a target video based on a source video and a textual modification instruction. This task demands fine-grained reasoning over multimodal transformations. However, existing benchmarks predominantly focus on vision–text alignment, largely overlooking the rich semantic signals embedded in audio—such as speech, music, and environmental sounds—which are often decisive for comprehensive video understanding. To bridge this gap, we introduce **OmniCVR**, a large-scale benchmark for omni-composed video retrieval that establishes vision, audio, and text as first-class modalities. OmniCVR is constructed via a scalable, automated pipeline integrating content-aware segmentation, omni-modal annotation, and a rigorous dual-validation protocol involving both large language models and human experts. The benchmark comprises vision-centric, audio-centric, and integrated queries, with the latter forming the majority to accurately reflect real-world multimodal complexity. Furthermore, we propose **AudioVLM2Vec**, an audio-aware extension of VLM2Vec. By incorporating explicit audio semantics, AudioVLM2Vec achieves state-of-the-art performance, highlighting fundamental limitations in the audio reasoning capabilities of current multimodal retrieval systems.

Understanding tens-of-minutes surgical videos requires long-horizon temporal reasoning, answering what happens before, after, or across stages of a procedure by grounding the question in visual evidence spread across time. Existing approaches handle this poorly: a one-shot vision-language model (VLM) compresses the whole procedure to fit its context window and loses the detail a "before" or "after" question depends on, while video agents that train the model where to look are data-hungry and transfer poorly to out-of-domain surgery. We build an agent harness that separates reasoning from perception and improves by evolving context rather than optimizing weights. A text-only orchestrator plans which evidence to gather and issues an auditable sequence of tool calls, while frozen vision-language sub-agents execute each call over the pixels, viewing, cropping, inspecting frames, and retrieving external knowledge. We further propose a gradient-free, reward-gated Heuristic Skill Distillation loop that mines the agent's own low-scoring traces and keeps a candidate skill only when it raises a validation reward, yielding reusable retrieval skills, notably directed re-look. Growing an external skill library rather than tuning weights, the loop adapts from only about 100 labeled examples, far fewer than supervised or reinforcement fine-tuning requires. To evaluate this agent, we introduce MedClawBench, a de-leaked, doctor-grounded benchmark of 1,123 questions over self-built long neurosurgery recordings and a held-out public lecture-video test split. Across both datasets and all four evaluation dimensions, our agent consistently outperforms one-shot VLMs and general video-agent frameworks, with the largest gains on the long, out-of-domain neurosurgery videos. Project page: https://fyycs.github.io/medclaw/.

Generalist robot policies aim to map multimodal observations and linguistic task instructions to actions across diverse tasks. However, existing methods typically represent the future as a fixed, short video-action chunk. This short-term future captures local scene evolution for action execution, but it does not explicitly describe the stage-level future that specifies how a task should progress from its current stage to the next. We therefore distinguish two complementary futures for robot manipulation: a short-term physical future to capture local scene evolution and a stage-level semantic future to represent task progress. We introduce StageWAM, which augments a Motus-based World Action Model (WAM) with Stage-JEPA, a goal-conditioned Joint-Embedding Predictive Architecture (JEPA) predictor. Given the current observation and task instruction, Stage-JEPA uses a frozen V-JEPA2 encoder to extract the current-state representation and predicts the latent target of the next inferred stage. Across 50 RoboTwin 2.0 tasks in clean and randomized environments, StageWAM achieves 90.25

Evaluating the alignment capabilities of large Vision-Language Models (VLMs) is essential for determining their effectiveness as helpful assistants. However, existing benchmarks primarily focus on basic abilities using nonverbal methods, such as yes-no and multiple-choice questions. In this paper, we address this gap by introducing AlignMMBench, which provides more nuanced evaluations of alignment capabilities and is the first benchmark specifically designed for Chinese visual contexts. This benchmark is meticulously curated from real-world scenarios and internet sources, encompassing thirteen specific tasks across three categories, and includes both single-turn and multi-turn dialogue scenarios. Incorporating a prompt rewrite strategy, AlignMMBench encompasses 1,054 images and 4,978 question-answer pairs. To facilitate the evaluation pipeline, we develop CritiqueVLM, a rule-calibrated evaluator that exceeds GPT-4's evaluation ability. Additionally, we measure the "alignment score", a quantitative metric designed to assess the robustness and stability of models across diverse prompts. Finally, we evaluate the performance of representative VLMs on AlignMMBench, offering insights into the capabilities and limitations of different VLM architectures. The evaluation code and data are available at https://github.com/THUDM/AlignMMBench.

We present GLM-4.1V-Thinking, GLM-4.5V, and GLM-4.6V, a family of vision-language models (VLMs) designed to advance general-purpose multimodal understanding and reasoning. In this report, we share our key findings in the development of the reasoning-centric training framework. We first develop a capable vision foundation model with significant potential through large-scale pre-training, which arguably sets the upper bound for the final performance. We then propose Reinforcement Learning with Curriculum Sampling (RLCS) to unlock the full potential of the model, leading to comprehensive capability enhancement across a diverse range of tasks, including STEM problem solving, video understanding, content recognition, coding, grounding, GUI-based agents, and long document interpretation. In a comprehensive evaluation across 42 public benchmarks, GLM-4.5V achieves state-of-the-art performance on nearly all tasks among open-source models of similar size, and demonstrates competitive or even superior results compared to closed-source models such as Gemini-2.5-Flash on challenging tasks including Coding and GUI Agents. Meanwhile, the smaller GLM-4.1V-9B-Thinking remains highly competitive-achieving superior results to the much larger Qwen2.5-VL-72B on 29 benchmarks. We open-source both GLM-4.1V-9B-Thinking and GLM-4.5V. We further introduce the GLM-4.6V series, open-source multimodal models with native tool use and a 128K context window. A brief overview is available at https://z.ai/blog/glm-4.6v. Code, models and more information are released at https://github.com/zai-org/GLM-V.

Vector-quantized variational autoencoders (VQ-VAEs) are discrete autoencoders that compress images into discrete tokens. However, they are difficult to train due to discretization. In this paper, we propose a simple yet effective technique dubbed Gaussian Quant (GQ), which first trains a Gaussian VAE under certain constraints and then converts it into a VQ-VAE without additional training. For conversion, GQ generates random Gaussian noise as a codebook and finds the closest noise vector to the posterior mean. Theoretically, we prove that when the logarithm of the codebook size exceeds the bits-back coding rate of the Gaussian VAE, a small quantization error is guaranteed. Practically, we propose a heuristic to train Gaussian VAEs for effective conversion, named the target divergence constraint (TDC). Empirically, we show that GQ outperforms previous VQ-VAEs, such as VQGAN, FSQ, LFQ, and BSQ, on both UNet and ViT architectures. Furthermore, TDC also improves previous Gaussian VAE discretization methods, such as TokenBridge. The source code is provided in https://github.com/tongdaxu/VQ-VAE-from-Gaussian-VAE.

User interface (UI) development requires translating design mockups into functional code, a process that remains repetitive and labor-intensive. While recent Vision-Language Models (VLMs) automate UI-to-Code generation, they generate only static HTML/CSS/JavaScript layouts lacking interactivity. To address this, we propose WebVIA, the first agentic framework for interactive UI-to-Code generation and validation. The framework comprises three components: 1) an exploration agent to capture multi-state UI screenshots; 2) a UI2Code model that generates executable interactive code; 3) a validation module that verifies the interactivity. Experiments demonstrate that WebVIA-Agent achieves more stable and accurate UI exploration than general-purpose agents (e.g., Gemini-2.5-Pro). In addition, our fine-tuned WebVIA-UI2Code models exhibit substantial improvements in generating executable and interactive HTML/CSS/JavaScript code, outperforming their base counterparts across both interactive and static UI2Code benchmarks. Our code and models are available at \href{https://zheny2751-dotcom.github.io/webvia.github.io/}{\texttt{https://webvia.github.io}}.

Beginning with VisualGLM and CogVLM, we are continuously exploring VLMs in pursuit of enhanced vision-language fusion, efficient higher-resolution architecture, and broader modalities and applications. Here we propose the CogVLM2 family, a new generation of visual language models for image and video understanding including CogVLM2, CogVLM2-Video and GLM-4V. As an image understanding model, CogVLM2 inherits the visual expert architecture with improved training recipes in both pre-training and post-training stages, supporting input resolution up to 1344 × 1344 pixels. As a video understanding model, CogVLM2-Video integrates multi-frame input with timestamps and proposes automated temporal grounding data construction. Notably, CogVLM2 family has achieved state-of-the-art results on benchmarks like MMBench, MM-Vet, TextVQA, MVBench and VCGBench. All models are open-sourced in https://github.com/THUDM/CogVLM2 and https://github.com/THUDM/GLM-4, contributing to the advancement of the field.

The Legendre transformation is a crucial tool in theoretical physics, known for its symmetry, especially when applied to multivariate functions. In statistical mechanics, ensembles represent the central focus. Leveraging the dimensionless aspect of Legendre transformation, this paper explores the transformation process from the entropy characteristic function of microcanonical ensembles to the analogous definition of partition function transformation. Additionally, it derives characteristic functions, partition functions, and establishes their interrelations, along with deriving corresponding thermodynamic formulas for various ensembles. This streamlined approach sheds light on the fundamental principles of statistical mechanics and underscores the symmetry inherent in Legendre transformation.

We introduce CogVLM, a powerful open-source visual language foundation model. Different from the popular shallow alignment method which maps image features into the input space of language model, CogVLM bridges the gap between the frozen pretrained language model and image encoder by a trainable visual expert module in the attention and FFN layers. As a result, CogVLM enables deep fusion of vision language features without sacrificing any performance on NLP tasks. CogVLM-17B achieves state-of-the-art performance on 10 classic cross-modal benchmarks, including NoCaps, Flicker30k captioning, RefCOCO, RefCOCO+, RefCOCOg, Visual7W, GQA, ScienceQA, VizWiz VQA and TDIUC, and ranks the 2nd on VQAv2, OKVQA, TextVQA, COCO captioning, etc., surpassing or matching PaLI-X 55B. Codes and checkpoints are available at https://github.com/THUDM/CogVLM.

Objectives: Nirmatrelvir/ritonavir (N/R) is an effective drug for treating COVID-19. However, there is currently a lack of evidence for therapeutic drug monitoring of N/R, which may increase the risk of adverse drug reactions and compromise its efficacy. Methods: In this study, we retrospectively analyzed data from 139 patients in two center who were prescribed N/R. We collected baseline data from all patients and monitored nirmatrelvir and ritonavir concentrations on the third day of medication. We conducted a logistic regression analysis to investigate the relationship between drug concentration and prognosis. We also analyzed the correlations among features and used a random forest model to select significant factors that affect drug exposure. Subsequently, we constructed an XGBoost model to predict drug concentration using the selected features. Results: Our findings indicated that the concentration of N/R could not predict patient outcomes. We also identified potential factors that affect N/R concentration, including estimated glomerular filtration rate, creatine kinase, aspartate aminotransferase, alanine aminotransferase, lymphocytes, and platelet count. Ultimately, the evaluation of the predictive model resulted in a mean absolute error (MAE) of 0.717, mean squared error (MSE) of 1.328, root mean squared error (RMSE) of 1.152, and coefficient of determination (R-squared) of 0.779. The prediction model performs well and can provide risk prediction for medication management for N/R, as well as assist in personalized medication. Conclusions: We identified a set of variables that affect the treatment of N/R through therapeutic drug monitoring and established a machine learning model to identify drug risks. This provides a reference for clarifying the significance of therapeutic drug monitoring for N/R treatment and the subsequent development of multivariate prognostic models.