Objective: To investigate the effects of Trace element strontium prevention on Juvenile spontaneously hypertensive rats(SHR) elevated blood pressure and the mechanism.Methods: One hundred and seven SHR were randomly divided into five groups from A to E after one-week adaptive feeding:the pure water control group(n=22),the strontium water concentration 3mg/L group(n=22),the strontium water concentration 9mg/L group(n=19),the strontium water concentration 18mg/L group(n=22),and the strontium water concentration 36mg/L group(n=22).Normal diet was fed to all rats for twelve weeks.Each group was measured basal blood pressure in the beginning of the experiment.To the end,there were a total of ten blood pressure measurements.At the starts and the ends of the experiment,liver function and renal function were detected..Serum endothelin-1,rennin,angiotensin-II and noradrenalin were tested by Elisa.NF-κB,VCAM-1 and ICAM-1 levels of aortic were detected by immunohistochemical method.Results:(1) When SHR become adults,group E began to show a trend of decrease in blood pressure compared with group A(P0.05).Group D and E blood pressure are significantly lower than group A in the tenth,eleventh,and twelfth weeks(P0.01).Blood pressure in Group B and C declined compared with that in group A,.With the increasing of the strontium water concentration,blood pressure showed a gradual decline in the general trend.In group B-E,blood pressure was lower than that in group A(P0.05,P0.01).(2) Among all groups,there was no significant difference in liver function,renal function,ET-1,renin,Ang-II and NA after the feeding of strontium water(P0.05).(3) The integrated optical density(IOD)of NF-κB,VCAM-1,and ICAM-1 in aorta of group B-E are significantly lower than that in group A(P0.01).The NF-κB,VCAM-1 and ICAM-1 expression showed a decreasing trend accompanied with the increasing of strontium water concentration(P0.01).Conclusions: Trace elements strontium can delay the rise of SHR blood pressure and reduce the fluctuation of blood pressure.Its hypertension prevention mechanism may be due to inhibition of the classical pathway of NF-κB by decreasing VCAM-1,ICAM-1 and other inflammatory factors to reduce the blood vessel wall damage.

Objective To study the effect of Strontium on the development of experimental atherosclerosis in rabbits.Methods 71 New Zealand white rabbits were randomly assigned to five groups of A ~ E after one week of adaptive feeding: 15 in the pure water control group,14 in the Strontium-water group of concentration of 3 mg/L,16 in the Strontium-water group of concentration of 9 mg/L,12 in the Strontium-water group of concentration of 18 mg/L and 14 in the Strontium-water group of concentration of 36 mg/L.All the rabbits were given high fat diet of 120 g/day for 12 weeks.Serum lipids four total cholesterol(total cholesterol,TC),triglycerides(and triglyceride,TG),high density lipoprotein cholesterol(high-density lipoprotein cholesterol,HDL-C) and low-density lipoprotein cholesterol(1ow-density lipoprotein cholesterol,LDL-C) were tested at the beginning and end of experiment and serum inflammatory factors including high-sensitivity c-reactive protein(a high sensitive C of reactive protein,hs-CRP),endothelin-1(of endothelin-1,ET-1),white blood cells interleukin-2(interleukin-2,IL-2) and interleukin-6(interleukin-6,IL-6) were also detected with Elisa.Atherosclerosis area percentage was calculated with image processing software.Aortic HE-stained slices were observed with ordinary microscope and results were categorized to four grades of mild,moderate,severe and no significant changes according to atherosclerosis four classification criteria.Results ①after 12 weeks(on 13th week) of high-fat diet,there was a decreasing trend in the increase in four lipids in all the five groups,and increases in group D and E were much smaller than in group A;②Hs-CRP,ET-1,IL-2 and IL-6 increased significantly(P < 0.01) in all the groups after Strontium-water feeding,but increases were not significantly different among the different groups(P > 0.05);③atherosclerotic plaque area gradually reduced(P < 0.05,P < 0.01) with the increase of Strontium-water concentration in the five groups;④pathological results showed that all five groups of rabbits had the four classes of atherosclerosis of light,moderate,severe and no significant changes,while group A had mostly severe degree and group E had mostly mild and no significant changes,showing a overall trend of decrease from group A to E.Conclusion Trace element Strontium can delay the process of atherosclerotic plaque formation,and the higher the concentration,the effect concentration of the Strontium water the significant the effect.This effect of Strontium is related to its ability to enhance lipid metabolism.

近年来睡眠呼吸紊乱与心血管疾病的发病率和死亡率的相关性已越来越引起人们的关注[1,3].为提高冠心病患者对睡眠呼吸紊乱的危险性的关注,提高生存质量,本文通过对睡眠呼吸紊乱与冠心病相关性的研究,探讨冠心病伴睡眠呼吸紊乱患者的健康教育内容.

高龄老人抵抗力随着年龄递减,常并存慢性疾病,其呼吸道机械和免疫屏障随年龄下降,加上免疫功能失调及免疫缺陷,易发生重症肺部感染.我科收治1例高龄复杂重症肺部感染患者,经7个月临床治愈.治疗与护理报道如下.

利多卡因是快速制止严重心律失常的首选药物,属具有膜稳定作用的第一类抗心律失常药,用于临床40多年来一直被认为是一种安全有效的药物.