Objective:To investigate the expression and significance of CXCL12 and CXCR4 in gastric cancer.Methods:Fiftyfour patients with gastric cancer were examined with immunohistochemistry to measure the expression of CXCL12 and CXCR4.The corresponding adjacent tissues of gastric cancer were taken as control.The correlation of CXCL12 and CXCR4 expression and clinicopathological features was analyzed.Results:Positive staining for CXCL12 and CXCR4 was identified in 83.3% and 87.0% of the primary gastric tumor tissues,respectively,with significantly higher expression intensities observed in the primary gastric tumor tissues than in the adjacent normal mucosa tissues.Expression of CXCL12 in the gastric tumor tissues was significantly associated withlymph node and peritoneal metastasis.Significant association between CXCR4 and lymph node metastases was seen.Conclusion:CXCL12 and CXCR4 are related to formation of gastric tumors and metastasis.Furthermore,the expression of CXCL12 and CXCR4 could be used as a biomarker to predict lymph node and peritoneal metastasis of gastric cancer.

Objective To investigate the expression and significance of IGFBP-2 in lung adenocarcinoma.Methods Fifty patients with lung adenocarcinoma were examined with immunohistochemistry to measure the expression of IGFBP-2 and their corresponding adjacent tissues were taken as the control.The correlation of IGFBP-2 expression and clinicopathological features was analyzed.Results The expression rate of IGFBP-2 in lung adenocarcinoma(74%) was significantly higher than in adjacent normal lung tissues(8%).In lung adenocarcinoma,IGFBP-2 expression was associated with lymph node metastasis and poor differentiation.Conclusion The higher expression of IGFBP-2 in lung adenocarcinoma may contribute to the occurrence,development and turnover of lung adenocarcinoma.

<正> 近年来,头孢菌素类药物以其抗菌谱广、杀菌力强、耐药、耐酶等优点在临床应用日益广泛,随之而来的不良反应(ADR)发生率和耐药菌株的产生,呈逐年上升趋势。为了能更安全有效地使用本类药物,就其常见的不良反应及临床对策进行探讨,供临床参考:1常见的不良反应分类1.1过敏反应过敏反应是头孢类最主要的不良反应,发生率主要表现为皮疹、约为0.5%～10%。荨麻疹、哮喘、药热、血

<正>慢性阻塞性肺疾病急性加重(AECOPD)是COPD病程分期中的急性加重期,是指在疾病的过程中,短期内咳嗽,咳痰,气短和(或)喘息加重,痰量增多,呈脓性或黏液脓性,可伴发热等症状。我院自2005年1月～2009年1月,收治因COPD急性发作、严重的支气管+肺部感染导致重症Ⅱ型呼吸衰竭和肺性脑病,且符合气管插管及机械通气条件

母儿血型不合溶血性疾病是一种与血型有关的同种异源免疫性疾病,发生在胎儿期和新生儿早期,是胎儿新生儿溶血性疾病(haemolytic disease of the fetus and newborn,HDF)中重要的病因,围生儿溶血性贫血、心衰、水肿是其主要症状[1].