Abstract Background Perceived social support was considered to be an essential resource of individual’s positive consequences (e.g., posttraumatic growth, PTG) during times of stressful conditions. However, there is no evidence on the relationship between perceived social support and PTG at the couple-based level in cancer research. This study aimed to explore the relationship between perceived social support and posttraumatic growth among couples coping with gynecological cancer. Methods A cross-sectional survey was conducted in China, from May 2019 to March 2020 in two comprehensive hospitals. A total of 126 couples, consisting of women diagnosed with gynecological cancer and their spouses, participated. The Multidimensional Scale of Perceived Social Support (MSPSS) and the Posttraumatic Growth Inventory (PTGI) were used to collect data. Paired t-tests, pearson’s correlations and actor-partner interdependence model (APIM) were used to analyze data. Results The actor effects of perceived social support on posttraumatic growth were supported (r = 0.419, p < 0.001; r = 0.467, p < 0.001); however, the partner effects of perceived social support on posttraumatic growth were not supported (r = -0.119, p>0.05; r = 0.130, p>0.05). Perceived social support was positively correlated between women diagnosed with gynecological cancer and their spouses (r = 0.244, p < 0.01). Furthermore, spouses’ perceived social support was positively correlated with women’s posttraumatic growth (r = 0.213, p < 0.05). Conclusions The actor effects of perceived social support on posttraumatic growth in couples coping with GC are supported. The findings also highlight that spouses’ perceived social support are positively correlated with women’s perceived social support and women’s PTG. Healthcare professionals should provide couple-based interventions that would increase couples’ identification and use of effective social support, and how to promote their PTG should be focused.

AbstractAimThe aim of this study was to explore the factors that are associated with posttraumatic growth among spouses of women diagnosed with gynaecological cancer.DesignA cross‐sectional descriptive study.MethodsA convenience sample of 312 spouses of women diagnosed with gynaecological cancer was recruited from two comprehensive hospitals in China, from March 2018 to March 2020. Demographic characteristics, cancer‐related characteristics, posttraumatic growth, perceived social support and coping were assessed using self‐reported questionnaires. Descriptive statistics and multiple linear regression analysis were performed. The methods were guided by the STROBE checklist.ResultsThe mean score of posttraumatic growth was 46.7 (standard deviation = 16.7). The associated factors of posttraumatic growth were spouses' age, perceived social support, problem‐focused coping, dysfunctional coping (e.g. denial) and cancer treatment received by partners, which accounted for 34% of total posttraumatic growth score.Patient or public contributionAll participants contributed to the conducting of this study by completing self‐reported questionnaires.

To explore the prognostic potential of AK021443 in non-small-cell lung carcinoma (NSCLC), AK021443 levels in NSCLC specimens were determined by quantitative real-time polymerase chain reaction (qRT-PCR). The correlation between the AK021443 level and pathological factors in NSCLC patients was analyzed. Kaplan–Meier curves were plotted for assessing the prognostic value of AK021443 in NSCLC patients. Potential factors influencing NSCLC prognosis were analyzed by multivariable Cox regression test. AK021443 was upregulated in NSCLC specimens than normal ones. Its level was correlated to histological type, tumor differentiation, TNM staging, and lymphatic metastasis in NSCLC patients. AK021443 was the independent risk factor for the overall survival of NSCLC. AK021443 is highly expressed in NSCLC specimens, which is correlated to histological type, tumor differentiation, TNM staging, and lymphatic metastasis in NSCLC patients. It is the independent prognostic factor for NSCLC.

Aim: Care dependence has been scarcely investigated in coronary heart disease patients after percutaneous coronary intervention. This study aimed to investigate the association between frailty, self-efficacy, combined effects of frailty and self-efficacy, mental health, and care dependence in coronary heart disease patients after percutaneous coronary intervention. Design: Cross-sectional study. Methods: Data from 400 patients after percutaneous coronary intervention were collected from 2017-2020. Logistic regression model and mediating analysis were used to identify the association between frailty, self-efficacy, combined effects of frailty and self-efficacy, and care dependence. Results: Patients with frailty and self-efficacy tended to have severe care dependence symptoms. There was no correlation between frailty symptoms, self-efficacy, and care dependence in patients without symptoms of anxiety or depression. But in patients with anxiety or depression symptoms, there is a strong correlation between frailty symptoms, lower self-efficacy, and care dependence. Mental health played an inhibitory effect on frailty and care dependence.

Background: LncRNA PSMG3‑AS1 plays oncogenic role in breast cancer. However, its role in non-small cell lung cancer (NSCLC) is hardly known. We then studied the role of PSMG3‑AS1 in NSCLC.Methods: RT-qPCR was performed to determine the expression of PSMG3‑AS1 in NSCLC and non-tumor tissues from 60 NSCLC patients. A survival analysis was carried out to visit patients for 5 years to study the role PSMG3‑AS1 in prediction the survival of NSCLC. NSCLC cells were overexpressed with miR-340 or PSMG3‑AS1 to analyze the crosstalk between PSMG3‑AS1 and miR-340. MSP was performed to analyze the methylation of miR-340 miRNA gene. The invasion and migration abilities of cells were determind by Transwell assays.Results: PSMG3‑AS1 was highly expressed in NSCLC and was closely correlated poor survival. PSMG3‑AS1 and miR340 were inversely correlated. In NSCLC cells, PSMG3‑AS1 decreased the expression of miR-340 and increased methylation of miR-340 gene. However, miR-340 overexpression did not significantly affect the expression of PSMG3‑AS1. In addition, PSMG3‑AS1 overexpression resulted in upregulated expression of ROCK1. PSMG3‑AS1 and ROCK1 overexpression increased cell invasion and migration rates. MiR-340 overexpression suppressed cell behaviors and inhibited the role of PSMG3‑AS1.Conclusions: PSMG3‑AS1 may downregulate miR-340 through methylation to upregulate ROCK1 and promote cell invasion and migration in NSCLC.

目的 分析近20年我国妇科肿瘤护理的研究现状,为今后相关研究提供参考.方法 分别以“妇科肿瘤”“妇科癌症”“护理”为检索词,检索时间为2000年1月～2019年6月.采用文献计量学法对文献年度发文量、文献地区分布、文献期刊分布、作者合作以及高频关键词共词情况进行统计.结果 检索筛查后纳入1586篇.统计结果显示发文量整体呈上升趋势;核心区域期刊有21种;核心作者群已形成但合作度、合著率不高;文献地区分布差异明显;研究主题多样化,近20年的研究热点有“化疗”“护理干预”“生活质量”“优质护理”“心理护理”.结论 我国妇科肿瘤护理研究有了一定的发展,但文献质量不高,研究的广度和深度不够.因此,在以后的发展中需加强对该领域研究的关注和投入,以期更好地促进我国妇科肿瘤护理质量的持续改进.

Objective:To explore the status and influencing factors of optimistic coping among gynecologic tumor patients.Methods:A total of 401 cases of gynecologic tumor patients was selected by the convenient sampling method. They were investigated by the Jalowiec Coping Scale, The Eysenck Personality Questionnaire-Revised Short Scale for Chinese, General Self-Efficacy Scale, Social Support Rating Scale.Results:Optimistic coping in gynecologic tumor patients scored (1.61±0.36). The main influencing factors included residence place, education level, general self-efficacy score, personality trait score, they could explain 25.2% variation of optimistic coping of gynecological tumor patients.Conclusions:Optimistic coping in gynecologic tumor patients scored is at a low level. Residence and education level, general self-efficacy score and personality trait score are important factors that affect the level of optimistic coping in gynecologic tumor inpatients. Medical staff should develop targeted nursing intervention measures, pay attention to mining and shaping patients' positive and optimistic personality traits, in order to improve patients' optimistic coping level, to achieve the ultimate goal of improving patients' quality of life nursing.