<正>近年研究发现,硒具有促进和调节人体免疫、抗肿瘤、抗氧化等许多重要的生理功能。我国70%的地区属于缺硒或低硒地区[1],因此日常补硒就成为保证机体硒需要量的重要途径。但是在临床上补硒的量并没有确定一个适当的范围,结果造成一部分人盲目补硒,使硒的摄入量过大或摄入时间过长,导致硒中毒时有发生。正常机体中各T淋巴细胞亚群相

<正>硒是谷胱甘肽过氧化物酶(GSH-Px)的重要组成部分,是动物体内必需的一种微量元素[1],对动物的繁殖机能有着重要的生物学意义。硒具有双向调节作用,其安全阈值非常小[2],高硒浓度范围内硒生物效应表现为毒性作用。目前,亚硒酸钠对动物繁殖性能的影响集中在补硒可提高动物生产性能和预防奶

To research the acute toxicity action and the median lethal dose(LD50) of sodium selenite in mice.To observe the toxic reaction and death of mice for seven days,the sodium selenite solution for 70 mice was used as 2.77,4.3,6.67,10.3,16 and 24.8 mg·kg-1 in each group to intragastric administration,distilled water was used in control group,the toxic effect was observed and the LD50 were calculated by Modified Karber's method.The dose of LD50 of sodium delenite in mice was 10.8 mg·kg-1,and a 95% confidence range of its LD50 was 9.0-13.0 mg·kg-1.The safety dosage should be considered on clinical application and which should be on toxicology research because the determinate toxicity that sodium selenite had.

<正>氟磺胺草醚是二苯醚类除草剂[1],在大豆田中除阔叶杂草极为有效。随着大豆农田杂草群落演替,难治杂草增多,氟磺胺草醚成为大豆田中防治难治杂草必用品种。在氟磺胺草醚使用中存在随意增加用药量、药械不标准而重复喷洒等问题,导致残留危害问题日益突出[2],对人类和动物存在潜在威胁,另外也存在动物误食刚喷洒过农药的草而引起中毒的可