The sustainable development of nuclear energy necessitates efficient treatment for uranium-containing wastewater. Although photocatalytic reduction of U(VI) is a promising technology, it is often limited by inefficient photogenerated carrier separation, low reduction efficiency, and prolonged reaction time. Herein, a pioneering strategy was proposed to achieve ultrafast removal of U(VI) from real uranium mine wastewater under air without sacrificial agents using external thermal-assisted photocatalytic reduction technology. A direct Z-scheme heterojunction of TDPP0.025/CdS was constructed by in-situ growth, achieving a U(VI) removal ratio of up to 98.79% from aqueous solution with a reduction rate constant of 0.44 min- 1 in 10 min under external thermal assistance at 80 degrees C, which was 18.5 times higher than that at 30 degrees C. For real uranium mine wastewater, an excellent removal ratio of 94.59% for U(VI) has been fulfilled within 30 min. The excellent performance was attributed to the synergistic effect of abundant S-vacancies, built-in electric fields, and external thermal assistance. The uranium reduced by photocatalysis was mainly deposited on the CdS surface in the form of UO2.34. The e- and & sdot;O2- free radical were the important participants, and the former played the dominant role. External thermal-assisted photocatalytic reduction of U(VI) provides a pioneering solution for ultrafast and efficient recovery of uranium from nuclear wastewater.

The overuse of antibiotics has led to bacterial infections becoming increasingly difficult to treat. Therefore, it is necessary to find an effective way to enhance the antibacterial activity of existing antibiotics. Some flavonoids have antibacterial property and poor bioavailability, which are difficult to be absorbed and utilized. In this paper, a nanoflower like Cu based metal-organic frame (MOF) with beta-cyclodextrin (beta-CD) and H3BTC (BTC) as ligands was prepared by solvothermal method using DMF and MeOH as the solvent. The combined application of as-synthesized nanoflower like MOF and Baicalin (BA) enhances the Fenton-like reaction and cell membrane lysis ability, significantly improving the inhibitory effect of the drug on both Gram-positive and Gram-negative bacteria. Moreover, the combined utilization of MOF and tedizolid phosphate has achieved a synergistic antibacterial effect. The as-synthesized MOF was proved to be able to increase the drug solubility and had a high drug loading and encapsulation rate for BA and tedizolid. In addition, Cu based MOF possess the glutathione depletion capacity which may improve the antibacterial ability of drug. Studies have shown that as-synthesized MOF has good biosafety and biocompatibility. The drug delivery system developed in this study can be applied in various fields such as medicine, food preservation and environmental protection, which provided an effective strategy for enhancing the antibacterial properties of drug.

Per- and polyfluoroalkyl substances (PFAS) have attracted increasing concern due to their environmental persistence and potential adverse health effects. In this study, a high-performance liquid chromatography-tandem mass spectrometry method was developed for the simultaneous determination of 56 PFASs in human plasma. After the plasma sample was extracted with methanol, 5 mg primary secondary amine (PSA), 20 mg graphitized carbon black (GCB), and 30 mg C18 were added for QuEChERS purification, followed by nitrogen drying and reconstitution. The chromatographic separation was performed on a C18 column with a gradient elution and was quantified on mass spectrometry with electrospray ionization in negative mode. The method was validated and good linearity was obtained in the range of 0.050-50.0 ng/mL. The limits of detection were 0.0024 to 2.05 ng/mL, and except for a few perfluoroalkyl phosphinic acids and fluorinated polymer-based substances with low signal intensities, most PFASs showed satisfactory recoveries of 70-120%, with relative standard deviations below 12%. The validated method was applied to analyze plasma samples from pregnant women and males over 50 years old. The results revealed widespread PFAS contamination in the population, with perfluoroalkyl carboxylic acids as the dominant contributors, followed by perfluoroalkyl sulfonic acids and accompanied by a limited number of emerging PFAS alternatives. There are population-specific differences in PFAS exposure, with median concentrations typically higher in males aged over 50 years than in pregnant women, but 6:2 FTS is much higher in pregnant women. The established method is sensitive and efficient, and the results highlight the importance of population-stratified biomonitoring of PFASs.

Drug delivery systems have long faced a fundamental challenge: achieving high drug-loading efficiency, precise control over release, and in vivo safety simultaneously is a difficult task. Cellulose and its derivatives are abundant and renewable, exhibiting good biocompatibility, which makes them promising candidates for drug delivery materials. Representative derivatives, such as carboxymethyl cellulose, hydroxypropyl methyl cellulose, and ethyl cellulose, as well as nanocellulose, including cellulose nanocrystals, cellulose nanofibrils, and bacterial nanocellulose, have enabled the development of diverse carrier formats, including hydrogels, aerogels, films, and particulate systems. Recent advances include pH-responsive bacterial nanocellulose/carboxymethyl cellulose hydrogels for oral ibuprofen delivery, carboxylated nanocellulose/polyethylene glycol/β-cyclodextrin composite aerogels for gastric-selective release of imatinib, and hydroxypropyl methyl cellulose-based microneedle patches for transdermal co-delivery of sumatriptan succinate and naproxen sodium. These examples highlight how cellulose-based systems can be engineered for site-selective delivery, sustained release, and multi-stimuli responsiveness. In this review, we summarize the structural features of cellulose derivatives and nanocellulose, discuss the design principles and release mechanisms of representative delivery platforms, and outline current challenges in manufacturability, safety evaluation, and clinical translation.

To evaluate CP for pesticide residue control in spices, dried Cinnamomum cassia Presl bark pieces fortified with eight pesticides were used as a controlled postharvest model. Volatilomics and untargeted metabolomics were further used to explore the related quality-modulation mechanisms. CP promoted pesticide degradation, with higher removal efficiencies obtained at increased power and treatment time. The mean degradation percentages generally showed an upward trend with increasing plasma power and treatment time. Among the conditions examined, treatment at 1.3 kW for 10 min produced the highest mean degradation percentage for each of the eight pesticides, with values ranging from approximately 15% to 55% in fortified cinnamon bark. CP also altered the surface structure and water status of cinnamon, as indicated by stronger surface etching, reduced contact angle, and decreased bound water content. Volatilomic analysis identified 111 volatile organic compounds, mainly terpenoids. CP increased the detectable abundance of key flavor- and function-related compounds, including d-limonene, cinnamyl acetate, β-elemene, and α−/β-pinene, and 30 volatile markers were screened. Untargeted metabolomics identified 164 metabolites and 52 differential metabolites, which were mainly annotated to carbohydrate-related pathways. Meanwhile, DPPH radical-scavenging and FRAP reducing capacities were higher after CP treatment, whereas antibacterial properties remained generally stable. These results indicate that CP can reduce pesticide residues in cinnamon while improving volatile flavor release and maintaining functional quality, providing a basis for its application in green processing of spices and plant-derived foods.

This study addresses the complicated pretreatment steps in pesticide residue detection of American Ginseng by introducing a simplified QuEChERS purification method. The core of this method is a novel composite material (PSA/WT@MeS) made by loading PSA and multi-walled carbon nanotubes onto a three-dimensional melamine sponge. This material effectively removes multiple interferents from complex matrices. When used in the QuEChERS workflow, it allows purification and separation of American Ginseng samples in a single step, greatly streamlining the traditional process. Combined with gas chromatography-mass spectrometry (GC-MS), 12 common pesticides in American Ginseng were measured. The method showed good linearity (R² > 0.99) for all 12 pesticides across the 1-20 µg/kg range. Detection limits ranged from 0.01 to 0.12 µg/kg, and quantification limits from 0.03 to 0.40 µg/kg. Matrix effects were kept within ±20%. At three spiked levels, average recoveries ranged from 87.8% to 109.8%, with relative standard deviations below 9.9%. This approach offers faster pretreatment and better purification. It provides a practical option for detecting pesticide residues in American Ginseng and other complex matrices.

Potassium–sodium niobate (KNN) ceramics are critical lead‐free piezoelectric materials, offering eco‐friendly alternatives with high performance for sustainable sensor applications. However, how to overcome the theoretical framework of conventional K/Na ratio limitation and achieve property enhancement in extreme composition remains to be fully understood. Herein, by combining density function theory calculation, Rayleigh analysis, and ferroelectric scaling behavior, the origin of property discrepancy in KNN‐based ceramics with extreme K/Na ratio is unveiled. Compared with Na‐rich sample, 2.3‐fold enhanced piezoelectricity can be achieved in K‐rich ceramics, superior to those with similar high K concentration. The deteriorated property in Na‐rich sample comes from the existence of in‐phase oxygen octahedron tilting (M 2 + ) mode, suppressing the polar () mode and leading to a higher energy barrier. Nevertheless, the absence of M 2 + mode and the multiphase coexistence with a maze‐like domain, promote polarization rotation and domain switching, resulting in improved piezoelectric response in K‐rich ceramics. A compression‐type accelerometer based on KNN with extreme K/Na ratio is designed and the sensitivity of K‐rich ceramics is also much higher than that of Na‐rich ones, highest in reported KNN‐based piezoelectric accelerometers. The study provides a new paradigm to boost electrical properties and reveals the underlying mechanism of property discrepancy induced by extreme K/Na ratio, beneficial to the development of sensor applications.

This study developed a rapid method for detecting pyrethroid pesticide residues using emulsive liquid-liquid microextraction (ELLME) coupled with high-performance liquid chromatography. In the ELLME, oleic acid (extractant) was mixed with an alkaline solution to generate an oil-in-water emulsion, which was subsequently added to the sample. This technique enabled rapid emulsification and extraction within 1 min without requiring any complex extraction devices. Subsequently, an acidic solution was introduced to induce immediate demulsification, achieving complete phase separation of oleic acid within 10 s, thereby eliminating the need for time-consuming centrifugation. This method operates based on the principle of pH-dependent modulation of oleate anion formation and emulsification, facilitating rapid extraction and efficient phase separation. Density functional theory calculations indicated that the van der Waals interactions predominantly governed the extraction mechanism. Five evaluation approaches were used to demonstrate the environmental sustainability of the extraction. When applied to environmental and food samples, the method demonstrated a satisfactory linearity range (0.005-0.5 mg L-1), recoveries (85.8 %-100.8 %), and relative standard deviations (0.6 %-6.5 %), confirming good accuracy and reproducibility. This approach provides a potential solution for rapid, simple, and environmentally sustainable monitoring of pyrethroid pesticide residues.

The prevalence of carcinogenic N-nitrosamines formed as byproducts during water treatment was public health of significant concern. The salt-assisted liquid-liquid microextraction (SALLME) combined with gas chromatography-tandem Q-Exactive Orbitrap mass spectrometry, employing programmed temperature vaporization-large volume injection (PTV-LVI) was developed for the determination of sixteen N-nitrosamines. The Plackett-Burman Design and Response Surface Methodology were applied to optimize the PTV-LVI parameters and sample pretreatment procedures. The optimal SALLME conditions were 200 μL dichloromethane as extraction solvent, 30 % (w/v) sodium carbonate concentration, and 40 s extraction time. The optimized PTV-LVI injection volume of 5 μL demonstrated approximately one order of magnitude greater sensitivity compared to conventional 1 μL splitless injection. Under these optimized conditions, the proposed method exhibited linearity correlation coefficients between 0.9947 and 0.9998 for sixteen N-nitrosamines within the range of 0.2-100 μg/L, except for NDMA and NMEA, which showed corresponding correlation coefficients of 0.9937-0.9941 over a linear range of 0.5-100 μg/L. The method detection limits ranged from 1.6 to 4.6 ng/L. The relative recoveries for spiked tap water samples at concentrations of 20 ng/L, 50 ng/L and 100 ng/L ranged from 60.4 % to 113.4 %, with the relative standard deviation below 10 %. The proposed method offered a rapid, environmentally friendly and highly sensitive alternative analytical method for the determination of trace level of N-nitrosamines in drinking water.

Induced resistance is an alternative disease control strategy for postharvest fruits and vegetables. Methyl jasmonate (MeJA) is a crucial phytohormone in the defense response to biotic and abiotic stresses. The effect and relevant mechanism of MeJA on the control of postharvest disease in mango fruit remain unclear. This study investigated the effect and possible mechanism of MeJA against stem-end rot caused by Lasiodiplodia theobromae in mango fruit. The results showed that MeJA significantly inhibited the lesion expansion on mango fruit inoculated with L. theobromae. 10 mu M MeJA treatment effectively induced disease resistance against L. theobromae during postharvest storage. MeJA enhanced the activities of defense-related enzymes, including phenylalanine ammonia lyase (PAL), peroxidase (POD), beta-1,3-glucanase (GLU), and chitinase (CHT), increased the accumulation of endogenous jasmonic acid (JA) and salicylic acid (SA) contents, up-regulated the expressions of the related genes on JA pathway (AOS, JAR1, MYC2, and COI1) and SA pathway (ICS, and PR1), stimulated the contents of total phenolics and flavonoids, and inhibited the accumulation of malondialdehyde (MDA). Furthermore, MeJA delayed the ripening and senescence of the fruit by inhibiting the peel yellowing, flesh softening and change in soluble solids content (SSC) of mango fruit. The results indicated that the enhanced resistance of MeJA-treated mango to stem-end rot was potentially due to the activation of defense responses induced by synergistic interaction between JA and SA pathways, as well as delayed postharvest ripening. The MeJA treatment is a promising strategy to control stem-end rot of mango fruit.

Danning tablet (DNT) is a traditional Chinese medicine (TCM) that contains seven herbal ingredients. It has been clinically used to treat liver and gallbladder diseases in humans. However, the complex composition of TCM prescriptions makes it challenging to fully analyze different polar range compounds. The supercritical fluid chromatography (SFC) method has stronger selectivity for weak polarity and low volatility substances. In contrast, ultra-high performance liquid chromatography (UHPLC) has stronger selectivity for compounds with strong polarity and high boiling points, which offsets the disadvantages of SFC. We aimed to establish a complementary and integrated strategy for multicomponent characterization and attribution of DNT based on ultra-performance convergence chromatography (UPCC) and UHPLC combined with quadrupole-time-of-flight mass spectrometry (QTOF-MS) and identify the potential qualitative indicator. The chemical compounds of DNT were analyzed by matching the self-built databases on the UNIFI platform. Network pharmacology was used to verify the reasonableness of the qualitative indicators with the relevant targets and the enrichment pathways related to the treatment of DNT. A total of 247 compounds were characterized. Specifically, the UPCC-QTOF-MS technology individually characterized 73 compounds. The UHPLC-QTOF-MS technology individually characterized 75 compounds. As a result, the study defined 11 compounds as the potential qualitative indicators. The relevant targets and the enrichment pathways related to the treatment of DNT were constructed. This study completed the comprehensive characterization of the full coverage of the polarity of DNT. The potential qualitative indicators can be extended to improve the accuracy of DNT quality evaluation.

In the process of extracting bioactive ingredients from plant materials, the main resistance to the diffusion of bioactive ingredients into the solvent is cell wall structure of plant materials. The cold plasma, whose temperature of the whole system is close to or slightly higher than the room temperature, has been widely used as a treatment technology prior to extraction due to the advantages of low temperature, high efficiency, low energy consumption, environmental friendliness, and so on. It can effectively disrupt cell wall structure, increase surface hydrophilicity of plant materials, and thus significantly improve the extraction efficiency of plant bioactive ingredients. The current review gives a detailed overview of cold plasma pretreatment technology in order to provide valuable information for scholars who are interested in this field. The structures of dielectric barrier discharge (DBD) and glow discharge plasma generation system are introduced, respectively. The enhanced mechanism of the high efficiency is discussed in detail. Several critical factors such as working gas, output power/output voltage, treatment time, soaked/dried raw materials are fully analyzed. Recent applications on the extraction of various bioactive ingredients are listed and discussed. Finally, its future development is prospected.

Background: The ongoing infusion of pharmaceutical and personal care products (PPCPs) into ecosystems sustains a perpetual life cycle and leads to multi-generational exposures. Limited understanding of their environmental impact and their intrinsic ability to induce physiological effect in humans, even at low doses, pose great risks to human health. Few scholarly works have conducted systematic research into the occurrence of PPCPs within potable water systems. Concurrently, the associated monitoring techniques have not been comprehensively examined with regards to the specific nature of drinking water, namely whether the significant presence of disinfectants may influence the detection of PPCPs. Results: A modified approach in terms of detailed investigation of sample preservation and optimization of an inlab fabricated solid phase extraction (SPE) cartridge filled with DVB-VP and PS-DVB sorbent was proposed. Favorable methodological parameters were achieved, with correlation coefficients spanning from 0.9866 to 0.9998. The LODs of the PPCPs fluctuated from 0.001 to 2 mu g L-1, while the LOQs varied from 0.002 to 5 mu g L-1. The analysis of spiked samples disclosed a methodological precision of 2.31-9.86 % and a recovery of 52.4-119 %. We utilized the established method for analyzing 14 water samples of three categories (source water, finished water and tap water) from five centralized water supply plants. A total of 24 categories encompassing 72 PPCPs were detected, with the concentrations of PPCPs manifested a marked decrease from source water to finished water and finally to tap water. Significance: Our research meticulously examined the enhancement and purification effects of widely used commercial SPE cartridges and suggested the use of in -lab fabricated SPE cartridges packed with DVB-VP and PSDVB adsorbents. We also conducted a systematic evaluation of the need to incorporate ascorbic acid and sodium thiosulfate as preservatives for PPCP measurement, in consideration of the unique characteristics of drinking water matrices, specifically, the significant concentration levels of disinfectants. Furthermore, the proposed method was effectively employed to study the presence of PPCPs in source water, finished water, and tap water collected from centralized water supply plants.

Aging is a critical global issue that contributes to the high incidence of Alzheimer's disease (AD). Blood screening emerges as the most promising measure for early diagnosis and intervention of AD due to its noninvasive and low cost. However, the practical application of AD blood screening confronts two significant challenges. First, due to the blood-brain barrier, the concentration of AD biomarkers in blood is much lower than that in cerebrospinal fluid. Second, simultaneous quantitative analysis of multiple biomarkers is necessary due to the low specificity of individual biomarkers. Herein, we propose DNAzyme-based 3D DNA walkers for the sensitive and multiplex detection of five AD-associated miRNA biomarkers: hsa-miR-125b, hsa-miR-342-3p, hsa-miR-29b, hsa-miR-191-5p, and hsa-miR-7d-5. The DNAzyme-based 3D DNA walkers provide highly efficient and autonomous amplification of the minimal biomarkers' quantities. The walking-released metal isotopes 89Y, 165Ho, 139La, 140Ce, and 159Tb can be sensitively detected by elemental mass spectrometry without any spectral overlap. The detection limit was achieved to be as low as 1.0 fmol. The proposed method was successfully applied to human serum samples with satisfactory spiked recoveries. With its high sensitivity and multiplexity capabilities, this metal isotope strategy may contribute to the early diagnosis and intervention of AD.

Background: Conventional solvents used to extract plant active ingredients such as water, methanol, ethanol, propanol, etc. have no purification function. Thus, the contents of impurities in the extracts are higher, which increases the difficulty of the subsequent process. An aqueous two-phase system (ATPS) based on short-chain alcohol and salt is a novel solvent, which has the advantages of excellent phase separation effect, high selec-tivity, low viscosity, low cost, easy recycling, environmental friendliness, and so on. It is a potential alternative for conventional solvents and has been widely used in the extraction of plant active ingredients.Scope and approach: This review summarized the research progress of short-chain alcohol/salt-based ATPS for recovery of plant active compounds, including the principle and mechanism, the main factors affecting the ef-ficiency, the applications in recent years, etc., and put forward the future perspective. Key findings and conclusions: The present results indicate that alcohol/salt-based ATPS can significantly improve the purity of extracts while obtaining higher extraction efficiency with the aid of ultrasound or microwave. Therefore, alcohol/salt-based ATPS plays an important role in improving the recovery of plant active ingredients, and has a broader application prospect in the industrial production.

With the outbreak of the new coronavirus disease 2019 (COVID-19), the rapid spread of the virus has brought huge economic losses and life threats to the world. So far, we have entered the third year of the epidemic and there is an urgent need to provide more anti-viral treatment along with vaccination. Recent studies have confirmed that Cepharanthine (CEP) has strong antiviral efficacy, which is a potential drug against COVID-19. As a natural active alkaloid, the development of CEP-incorporated products is dependent on the extraction, purification and identification of CEP. This review gives a brief introduction of CEP, including its origin and classification, and its conventional and novel extraction techniques. In addition, the purification and identification techniques are summarized. In the last, the future research directions are proposed. It can be found from this review that the extraction from plants is still the main way to obtain CEP, and it is necessary to use innovative techniques and their hybrid extractions to extract CEP. More efficient extraction and purification techniques should be used to extract CEP in the future. This review provides a basis for the development of novel extraction and purification techniques and industrial utilization of CEP.

Internal fungal infection and pest invasion are defects commonly found in dried longan fruits, which cannot be visualized easily without peeling. The present work was aimed to develop a non-destructive method for discriminating defective dried longan fruits via measuring the transverse relaxation times (T 2 ) by Low-Field Nuclear Magnetic Resonance (LF-NMR) that characterized the bound water in the fruits, with 274 in total and defects versus normal at 107:167. A decreasing tendency of transverse relaxation amplitude in defective samples was observed, consistent to the change of proton density distribution by Magnetic Resonance Imaging (MRI) with weakened signal in moldy/wormy flesh shown compared with normal ones. Both Principal Component Analysis (PCA) and Deep Learning Neural Network (DLNN) models were applied to analyze the T 2 relaxation time for predicting the defective fruits. The DLNN model yielded a satisfactory performance and achieved accuracy, recall and F-score marks up to 89 %, 82 % and 86 % for 10-fold cross validation, respectively, compared with approximately 80 %, 60 % and 74 % by PCA cluster. This study highlighted a novel non-destructive approach for discriminating defective dried longan fruits of high efficiency featured by high recall, precision and accuracy using DLNN modeling based on LF-NMR.

Lycium ruthenicum is regarded as a good source of natural anthocyanins. In this work, we proposed a novel semi-continuous liquid-phase pulsed discharge (LPD) system for the extraction of anthocyanins from Lycium ruthenicum. The optimized conditions for this method were: 20% ethanol concentration, 7 pH value, 8 kV input voltage, 27 mL/min volume flow, and 8 min treatment time. Under these conditions, a maximum anthocyanins recovery rate (95.69%) was obtained. Compared with batch LPD and heat-assisted extraction (HAE), semicontinuous LPD showed higher anthocyanins yield, shorter time, and lower energy consumption. The antioxidant activity of extracts was determined by scavenging ability of DPPH and ABTS radicals and, reducing ability of Fe3+. The results indicated that the antioxidant activity of batch LPD, HAE, and semi-continuous LPD were similar. Besides, the HPLC chromatograms showed that three methods had similar anthocyanins composition. Thus, semi-continuous LPD was an good and promising method for the extraction of natural anthocyanins.

The misuse of antibiotics like levofloxacin (LVX) makes them ubiquitous in many water bodies. They are difficult to degrade and threaten the health of living creatures. In this work, we synthesized a series of electrodes with single-atom-kernelled nanocluster particles, among which the Ru-Ni/CNT electrode containing Ni single-atom-kernelled Ru nanocluster particles showed the most excellent electrocatalytic activity to degrade LVX. Within 30 minutes, the LVX conversion rate of the Ru-Ni/CNT electrode was 60.5% higher than that of the Ni/CNT electrode, while the primary reaction kinetics constant was 16.4 times higher than that of the CNT electrode. At the same time, Ru-Ni/CNT electrode revealed remarkable stability after 4 cycles of reaction. We then used STEM to determine the distribution of single atoms in the material, and to observe the electrode morphology with the assistance of SEM. XPS, CV, LSV, EIS and inhibitor quenching experiments were carried out to study the electrochemical mechanism. It was discovered that the unique structure of Ni single-atom-kernelled Ru nanocluster particles of the electrode regulates the reaction process. Ru nanocluster particles can provide protection for Ni, while Ni single-atom can promote the electron transfer of Ru nanocluster particles, resulting in a large number of reactive oxygen radicals (ROS) to degrade pollutants. We believe that this study presents food for thought to micro-control the surface of electrodes for specific applications.

Taste-and-odor occurrence has extensive socio-economic impacts on drinking water, which is now a public health concern. Sulfur odorants can significantly affect the esthetic quality of drinking water and arouse unpleasant organoleptic experience of consumers, which can also harm the human body at high concentration levels. Researches on analysis of sulfur odorants in air and environmental water are numerous, while the reports on analysis of them in tap water are few. The analysis of sulfur odorants in tap water is quite different with it in environmental samples owing to the treatment of the water plant, such as the introduction of disinfectants. In this paper, a novel and practical method for determining the dimethyl disulfide (DMDS) and dimethyl trisulfide (DMTS) in tap water and source water by purge-and-trap coupled to gas chromatography–mass spectrometry (GC–MS) analysis was proposed. The evaluations of sample preservation were performed due to the adverse impact caused by the remaining disinfectant in tap water on the analysis of DMDS and DMTS, including the investigation on the selection and the dosage of preservatives. Besides, aspects affecting the preconcentration procedure and GC–MS analysis of DMDS and DMTS were investigated as well. Moreover, the proposed method was validated by five independent laboratories from different regions of China, representing a good linearity with correlation coefficients (r) ranged from 0.9990 to 0.9999 for both DMDS and DMTS between the concentrations of 10 ng L−1 and 100 ng L−1. The method detection limit (MDL) and limit of quantification (LOQ) of DMDS and DMTS were 3 ng L−1 and 10 ng L−1, respectively. Meanwhile, satisfactory precision and accuracy were also obtained when the method was applied to detect DMDS and DMTS in tap water and source water. The relative standard deviation (RSD) was 0.90–7.3% for DMDS and 1.1–7.6% for DMTS, and the recovery was 81.2–120% for DMDS and 73.6–118% for DMTS. Furthermore, the repeatability limits and reproducibility limits of DMDS and DMTS were acquired, ranging from 0.631 to 5.71 at low, medium and high concentrations. The proposed method is an effective, environmentally friendly, and promising approach for routine monitoring of DMDS and DMTS in tap water and source water.