“Israeli Hope in Academia” is a program, designed by Israeli President, Reuven Rivlin. The program is based on the perception that Israeli society is changing, from having a clear majority and several minorities, to a society comprised of four principal sectors that are roughly similar in size. The program acts to encourage a more diverse and culturally competent higher education system that promotes partnership. Over the past year, students from various faculties in the Holon Institute of Technology (HIT), took part in a course called “Green Ambassadors”, which corresponds with the “Israeli Hope” program. In the course, the students studied environmental issues, and then passed that knowledge on to pupils in the religious elementary school “Yeshurun” in the city of Holon, through enjoyable educational activities. In order to illustrate the environmental topics, and to achieve high participation levels of the pupils, the students created a mobile laboratory containing experiments and demonstrations, in which the pupils took an active part. The final questionnaires, answered by the classes teachers, show high rates of pupil participation, understanding and enjoyment. Thus, the course managed to make a significant impact on the community, and achieve the goals set by the “Israeli Hope” program.

Adenosine diphosphate (ADP) receptors and protein-kinase C (PKC) isoforms play different role in platelet activity. In the present study, whole blood platelet adhesion at 200 - 1800 s-1 shear rates was investigated by Impact-R system, measuring percent of surface coverage (SC) by platelets. Gradual heightened shear rate par-alleled increase of platelet adhesion. At relatively low shear (200 and 1000 s-1) blockade of neither P2Y1 receptor nor P2Y12 receptor (by A2P5P and 2MeSAMP, respectively) affected SC. At high shear rate (1800 s-1) reduction of SC was observed by 2MeSAMP. Treatment of blood with PKCδ inhibitor (rottlerin) but not PKCα,β inhibitor (Gö6976) diminished platelet adhe-sion. Among all the agents, only combination of 2MeSAMP and rottlerin used at subthreshold concentrations was able to inhibit platelet adhesion under high shear condition. We suggest that platelet agonist-induced P2Y12 and PKCδ signaling essentially stimulates platelet adhesion under flow condition, the important initiating step of thrombin formation.

Throughout the years with the development of industry and technology, people have increased environmental pollution. Generating much waste, using non-recycling materials, all lead to an increase in environmental pollution. In an era in which technology is so developing at a dizzying pace, the demand for electricity is only increasing, this situation may bring to a crisis that will disrupt the economy’s operations. These are severe problems that threaten the normal existence of Earth and of course, our life. We are approaching an “irreversible point”. Environmental contamination, including air, water, soil, pollution, creating waste in huge amounts as well as the waste of energy. This is reflected in damaging the sea, contaminating the groundwater, increase in global temperature, global phenomena like “acid rain” and the lessening of the ozone layer. There is no room for deliberation we must not remain indifferent- the earth’s population must wake up and act quickly, unite and make a comprehensive change in order to reduce significantly the harm caused by the industry around the world. In this article, we will present a case study of the education of the future generation for sustainability, environmental protection through Renewable Energy by Remote and Online laboratories.

1 H.I.T - Holon Institute of Technology, Faculty of Engineering (ISRAEL)2 H.I.T - Holon Institute of Technology, School of the Multidisciplinary Studies (ISRAEL)3 H.I.T - Holon Institute of Technology, Dean of Students Office (ISRAEL)

Global energy consumption has reached unprecedented levels over the last century due to population growth and economic growth. There have been significant changes in the global energy economy to reduce greenhouse gas emissions and air pollutants. Due to this trend, many countries around the world are promoting electric technologies as fuel-saving alternatives. The Israeli energy industry integrates renewable sources into its supply system and streamlines consumption. Nevertheless, Israelis know too little about smart meters, energy storage systems, and other modern power grid technology, which enables a decentralized approach to energy management referred to as distributed energy systems (DES). Using distributed energy systems to generate energy on-site and manage loads can reduce costs, improve reliability, and secure revenue. An effective public education program can help prepare public opinion and reduce barriers to smart use and energy efficiency in the home. By educating schoolchildren, we will present a way to prepare the public in the community to accept distributed energy systems and renewable energy. In challenging times, it is vital to make great efforts and to remember that change begins with education and that the best way to achieve intelligent usage and energy efficiency is to start with our children.

Appears in: EDULEARN22 Proceedings Publication year: 2022Pages: 9-15ISBN: 978-84-09-42484-9ISSN: 2340-1117doi: 10.21125/edulearn.2022.0008Conference name: 14th International Conference on Education and New Learning TechnologiesDates: 4-6 July, 2022Location: Palma, Spain

Background The cardiac ryanodine receptor type 2 (RyR2) is a large homotetramer, located in the sarcoplasmic reticulum (SR), which releases Ca2+ from the SR during systole. The molecular mechanism underlying Ca2+ sensing and gating of the RyR2 channel in health and disease is only partially elucidated. Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT1) is the most prevalent syndrome caused by RyR2 mutations. Methods and Results This study involves investigation of a family with 4 cases of ventricular fibrillation and sudden death and physiological tests in HEK 293 cells and normal mode analysis (NMA) computation. We found 4 clinically affected members who were homozygous for a novel RyR2 mutation, G3118R, whereas their heterozygous relatives are asymptomatic. G3118R is located in the periphery of the protein, far from the mutation hotspot regions. HEK293 cells harboring G3118R mutation inhibited Ca2+ release in response to increasing doses of caffeine, but decreased the termination threshold for store-overload-induced Ca2+ release, thus increasing the fractional Ca2+ release in response to increasing extracellular Ca2+. NMA showed that G3118 affects RyR2 tetramer in a dose-dependent manner, whereas in the model of homozygous mutant RyR2, the highest entropic values are assigned to the pore and the central regions of the protein. Conclusions RyR2 G3118R is related to ventricular fibrillation and sudden death in recessive mode of inheritance and has an effect of gain of function on the protein. Despite a peripheral location, it has an allosteric effect on the stability of central and pore regions in a dose-effect manner.

Creating a clean energyClean energy future is a worldwide goal. At present, world energy consumptionEnergy consumption relies heavily on fossil fuelsFossil fuel, which are non-renewableRenewables and eventually finite, such as coalCoal, oilOil, and natural gasNatural gas. These resources have already become too expensive and too environmentally damaging. The importance of renewable energyRenewable energy and energyEnergy efficient technologies is constitutively rising. How should children be taught about renewable energy? What is airAir pollution and how does harming the natural habitatNatural habitat affect us? StudentsStudent from the Holon Institute of TechnologyHolon Institute of Technology (HIT) participate in the course “Green ambassadorsGreen ambassador” which looks at these questions by integrating practical work. As part of the course requirements, studentsStudent are asked to conduct lessons within the topic of preserving the environmentEnvironment to fifth and sixth grade pupils in the Arabic elementary schoolElementary school “El OmariyaEl Omariya” situated in the cityCity of RamlaRamla. During meetings held within the school, the students taught the pupils, via games and activities, what renewable energyRenewable energy means, how to turn waste into a resource, what energy conversion and renewable energy mean, etc. In order to illustrate the topics studied by the pupils, the studentsStudent used a moveable laboratory containing demonstrations, experiments and creative activities. Environmental educationEnvironmental education, with an emphasis on renewablesRenewables, is the focus of this chapter.

H. Friman1, N. Matsliah1, Y. Sitbon2, I. Banner3, Y. Einav4, N. Shaked5 1H.I.T - Holon Institute of Technology, Faculty of Engineering (ISRAEL) 2H.I.T - Holon Institute of Technology, Dean of Students Office (ISRAEL) 3H.I.T - Holon Institute of Technology, Director of "Israeli Hope" (ISRAEL) 4H.I.T - Holon Institute of Technology, Dean of Students (ISRAEL) 5H.I.T - Holon Institute of Technology, Head of the Multidisciplinary Studies Department (ISRAEL)

: Trauma-induced coagulopathy (TIC) occurs commonly as a second event following severe injury. We evaluated the effects of fibrinogen, recombinant factor VIIa and factor XIII on blood clotting and fibrinolysis in an in-vitro TIC model. The TIC model included hemodilution, hyperfibrinolysis, acidosis and hypothermia. The extent of clot formation and fibrinolysis was evaluated using rotational thromboelastometry. Clot strength was increased following spiking the TIC blood with either 1.0 mg/ml fibrinogen, 3.0 μg/ml recombinant factor VIIa or 2.0 IU/ml factor XIII. Maximal effect was achieved by all agents in combination approximating the extent of clot formation to those in normal blood. Fibrinolysis was inhibited by factor XIII, while the reduction was stronger using all agents together. When each of the agents used in two times lower concentrations, clot strength was near to threshold. Fibrinogen and factor XIII but not factor VIIa exerted stimulation of clot strength, whereas synergistic effect of fibrinogen and factor XIII was observed. Maximal effect was achieved combining all agents. The antifibrinolytic effect was observed only by co-administration of fibrinogen, factor XIII and factor VIIa. On the basis of our study, we suggest that stimulation of clot formation and inhibition of fibrinolysis may be achieved by combination of FG, rFVIIa an FXIII using each of them at minimal effective concentration. Taken into consideration, multifactorial TIC pathogenesis, this approach may be preferable for improving coagulopathy than separate blood spiking with the essayed factors at high concentrations.

"Israeli Hope in Academia" is a program, designed by the president of the state of Israel, Reuven Rivlin. The program is based on the perception that Israeli society is changing, from having a clear majority and several minorities to a society comprised of four principal sectors that are roughly similar in size: secular Jews, religious Jews, Haredi (ultra-orthodox) Jews and Arabs. The program acts to encourage a more diverse and culturally competent higher education system that promotes partnership. One of the means to achieve that goal is to create meaningful educational interactions between people from academia and the younger generation of these sectors. Over the past year, students from various faculties in the Holon Institute of Technology (HIT) took part in a course called "Green Ambassadors", which corresponds with the "Israeli Hope" program. This course was considered an action learning course, which is a course that combines academic learning and social involvement that has an impact on the community. In order to illustrate the environmental topics and to achieve high participation levels of the pupils, the students created a mobile laboratory containing experiments and demonstrations in which the pupils took an active part. Thus, the course managed to make a significant impact on the community and achieve the goals set by the "Israeli Hope" program. This paper presents the "Israeli Hope" program, HIT and the "Green Ambassadors" course, as well as the methodology used to achieve the course's goals. Finally, this paper will discuss the success levels of the course.

Coagulation abnormalities are common following major trauma. The aim of this study was to assess the improvement of trauma-induced coagulopathy (TIC) in an in vitro model. TIC was created on blood taken from healthy individuals by inducing hemodilution, acidosis, hypothermia and fibrinolysis. Next, blood samples were subjected to rotational thromboelastometry to assess the effect of hemostasis modulators on blood coagulation and fibrinolysis. Introducing to blood fibrinogen at 0.75 mg/mL, prothrombin complex concentrate at 0.66 IU/mL or tranexamic acid at 95 µg/mL increased clot strength. Higher effect was observed by combination of fibrinogen with tranexamic acid and prothrombin complex with tranexamic acid, whereas the maximal effect was achieved using all agents together. Fibrinolysis was inhibited by tranexamic acid and stronger by triple combination of the agents. Selective treating the TIC blood with fibrinogen, prothrombin complex or tranexamic acid at two time lower concentrations did not affect clot strength. Combining fibrinogen with prothrombin complex or with tranexamic acid stimulated clot strength but at lower extent compared to higher concentrations. Lysis onset time was prolonged by tranexamic acid. Maximal effect on both clot formation and fibrinolysis was achieved using all three agents together. Blood clotting stimulation and fibrinolysis inhibition in the TIC model was enough combining subthreshold concentrations of fibrinogen, prothrombin complex and tranexamic acid. Further experiments are warranted in both in vitro and in vivo conditions with minimally effective concentrations of both pro-coagulant and anti-fibrinolytic drugs assuming that this combinatorial approach may not only improve coagulopathy but also minimize the risk of thrombotic complications.

H. Friman1, E. Dabbah1, N. Matsliah1, Y. Sitbon2, Y. Einav3, I. Banner4 1Faculty of Engineering H.I.T - Holon Institute of Technology (ISRAEL) 2Dean of Students Office. H.I.T - Holon Institute of Technology (ISRAEL) 3Dean of Students. H.I.T - Holon Institute of Technology (ISRAEL) 4Director of "Israeli Hope" program. H.I.T - Holon Institute of Technology (ISRAEL)

How should children be taught about renewable energy, what is air pollution? This paper reports on a specific case, perception and actual implementation in Hebrew - and Arab - speaking schools in Israel. In the last 4 years students from the HIT, Holon Institute of Technology participated in a course "green ambassadors" which combines practical work. As part of the course requirements, students were asked to conduct enjoyable lessons within the topic of preserving the environment to the pupils in the elementary school. During meetings held within the school, the students taught the pupils via games and activities what renewable energy means, how to turn waste into a resource, what energy conversion and renewable energy mean, etc. In order to illustrate the topics studied by the pupils, the students used a moveable laboratory containing demonstrations, experiments, and creative activities. The results show higher rates of success and involvement due to an enriching and challenging experience of learning. Thanks to all these, the pupils turned more aware and learned an important lesson about the ways to preserve the environment

“Israeli Hope in Academia” is a program, designed by the president of the state of Israel, Reuven Rivlin. The program is based on the perception that Israeli society is changing, from having a clear majority and several minorities, to a society comprised of four principal sectors that are roughly similar in size: secular Jews, religious Jews, Haredi (ultra-orthodox) Jews, and Arabs. The program acts to encourage a more diverse and culturally competent higher education system that promotes partnership. One of the means to achieve that goal is to create meaningful educational interactions between people from academia, and the younger generation of these sectors. Over the past year, students from various faculties in the Holon Institute of Technology (HIT), took part in a course called “Green Ambassadors”, which corresponds with the “Israeli Hope” program. This course was considered an action learning course, which is a course that combines academic learning and social involvement that has an impact on the community. In the course, the students studied environmental issues, and then passed that knowledge on to pupils in the religious elementary school “Yeshurun” in the city of Holon, through enjoyable educational activities. In order to illustrate the environmental topics, and to achieve high participation levels of the pupils, the students created a mobile laboratory containing experiments and demonstrations, in which the pupils took an active part. The final questionnaires, answered by the classes teachers, show high rates of pupil participation, understanding and enjoyment. Thus, the course managed to make a significant impact on the community, and achieve the goals set by the “Israeli Hope” program. This paper will present the “Israeli Hope” program, HIT and the “Green Ambassadors” course, as well as the methodology used to achieve the course’s goals. Finally, this paper will discuss the success levels of the course.

In the past decades, demographic and cultural changes are reshaping the Israeli society: It changed from a society constructed of a clear majority and minority to a society that is constructed of four central sectors: secular Jews; national-religious Jews; ultra-Orthodox Jews and Arabs. "Israeli Hope in the Academia", the academia has an essential role in shaping the "new Israeli order". The aim is to base the campuses as spaces for creating shared Israelite society that enables maintaining the unique identity of each group, to express the talents and excellence of the Israeli society, to promote a united vision of partnership in the universities and colleges. Ultra-Orthodox Jews society is known in Israel as a society that studies Torah in a way that deals less with science. In order to make scientific knowledge accessible to ultra-Orthodox Jews society in an experiential way as part of the "Israeli Hope in the Academy" program, this year the project "Together to Illuminate the World" was conducted jointly by the Unit for Social Involvement in the Dean of Students at HIT and the "Bnot Menahem" Elementary School in Holon. As part of the project, female students from the Holon Institute of Technology came to the school to teach girls (girls only, studies in separation) in the third grade. Among the topics studied in the project: What is energy? What are the transformations of energy? Ways to generate energy and create an electric circuit. At the end of the project, the students visited the Institute and conducted experiments at the Center for Excellence in Renewable Energies and the Smart Grid in the Faculty of Engineering. They listened to lectures on science and discoveries, green energy and also visited the 3D lab. The goal of the project was to show that there is no contradiction between religion and science. The product of the project was a solar menorah that every girl received. The menorah is a religious holiday symbol - Hanukkah, customary in Israel. The menorah is lit by solar energy, green and non-polluting.

"Israeli Hope in the Academy" is a program designed by the President of the State of Israel, Reuven Rivlin. The plan is based on the perception that Israeli society changes from a clear majority and a number of minorities to a society composed of four main sectors of similar size: secular Jews, religious Jews, ultra-Orthodox Jews, and Arabs. Severe socio-economic gaps between the four major sectors of Israel's population led Israeli President Reuven Rivlin to launch the flagship program "The Israeli Hope." The goal of the program is to establish a sense of partnership between the sectors, to promote the qualitative integration of each sector in the Israeli economy, and to create cooperation between sectors in key areas such as education, academia, employment, local municipalities, and sports. The purpose of the program is to strengthen the sense of togetherness in Israeli society while respecting each unique group from which it is composed. As such, "Israeli Hope" has several sub-fields, each focusing on another aspect of society. "Israeli Academic Hope" promotes a diverse and culturally diverse academic world. The program promotes a higher and culturally diverse education system that promotes partnership. One of the means to achieve this goal is to create meaningful educational interactions between academics and the younger generation of the sectors.

To investigate the urinary levels of TGF-β1, VEGF, and MCP-1 as potential biomarkers of latent inflammation and fibrosis in the kidney before and 6 months after correction of vesicoureteral reflux (VUR) in children.

Environmental Education is the key for creating a clean energy future for not only the nation, but the world. World Energy Consumption relies heavily on coal, oil, and natural gas. Fossil fuels are non-renewable, that is, they rely on finite resources that will eventually dwindle, becoming too expensive or too environmentally damaging to retrieve. In contrast, renewable energy resources, such as wind and solar energy, are constantly replenished and will never run out. Due to the rising need for professionals and academics with a background and understanding in the Energy field, Holon Institute of Technology (HIT) developed an integral system of environmental education and training and a new program at the Faculty of Electrical Engineering. The Renewable Energy program gives the students technical and practical aspects of energy use (technology and methodology of the study) and energy efficiency. The program also deals with minimizing the environmental impacts of energy use, as well as with energy economy and environmental policy. This article presents a new challenge. Teach environmental issues with language difficulties. Israeli Hebrew speaker students, teach environmental education in Arab school with Arabic speaker pupils’.