Background: This study aimed to investigate the relationship between the apparent diffusion coefficient (ADC) derived from diffusion-weighted imaging (DWI) and metabolic parameters obtained from 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) across different T-stages in patients with rectal cancer (RC), and to evaluate the prognostic significance of these imaging biomarkers for survival outcomes.Methods: This retrospective study included patients with non-mucinous rectal adenocarcinoma who underwent both pelvic magnetic resonance imaging (MRI) and 18F-FDG PET/CT before treatment. T-staging was performed using T2-weighted magnetic resonance imaging images, and ADC measurements were obtained from DWI. Metabolic tumor parameters, in-cluding maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG), were obtained from PET/CT images. A correlation analysis was performed between ADC and 18F-FDG PET/CT parameters and the T-stage. ROC curve analysis was performed to evaluate the diagnostic performance of ADC and 18F-FDG PET/CT parameters in the early T stage. Overall survival (OS) and progression-free survival (PFS) were estimated and analyzed.Results: A moderate negative correlation was found between T-stage and ADC (r = -0.43, p = 0.003), and a low-moderate positive correlation was found between TLG and ADC (r = 0.33, p = 0.027). ADC showed good diagnostic performance in identifying early T-stage tumors (AUC = 0.86; cutoff = 864 × 10⁻⁶ mm²/s). The OS in the low ADC group was 58.1±6.5 (45.3-70.9) and in the high ADC group 97.4±10.9 (76.1-110.8). PFS was 53.7±5.9 (42.1-65.1) in the low ADC group and 93.3±10.4 (73.0-113.6) in the high ADC group. OS (p = 0.018) and PFS (p = 0.042) were longer in the high ADC group, indicating a statistically significant association.Conclusion: ADC showed a significant association with both tumor stage and survival outcomes and may serve as a nonin-vasive prognostic biomarker in non-mucinous rectal adenocarcinoma. Although TLG correlated with T stage, PET/CT-de-rived metabolic parameters did not predict survival. These findings support the potential role of DWI in pre-treatment risk stratification.

Prognosis in small cell lung cancer (SCLC) remains poorly predicted by conventional staging and metabolic parameters. This study aimed to develop a positron emission tomography/computed tomography (PET/CT) based Radiomic Risk Score (Rad-Score), evaluate its independent prognostic value for overall survival (OS), and assess the clinical utility of an integrated model using Decision Curve Analysis (DCA). 143 SCLC patients (120 male, 23 female) who underwent pre-treatment staging 18F-fluorodeoxyglucose (18F-FDG) PET/CT between January 2012 and June 2024 were included. Using LIFEx (v25.06.1), 129 Image Biomarker Standardisation Initiative (IBSI) compliant radiomic features were extracted alongside standard metabolic parameters (SUVmax, SUVmean, MTV, TLG). After eliminating highly correlated features (|r|> 0.90), five key features were selected via tenfold cross-validation LASSO-Cox regression to construct the Rad-Score. Patients were stratified into Low and High Radiomic Risk groups. Independent prognostic factors were identified through Cox regression analyses, and the incremental value of the Rad-Score was assessed by hierarchical C-index comparisons and DCA. Median OS was 10.8 months (95

Objective: This study aims to identify the maximum standardized uptake value (SUVmax) value that predicts the presence of oligometastatic and high-risk prostate cancer and forecasts disease behavior. Materials and Methods: In this retrospective analysis, patients who underwent 12-quadrant transrectal prostate biopsy in our clinic were evaluated in the study. D’Amico risk scoring was performed. Data of non-metastasis, oligometastatic and multimetastatic patients were recorded using imaging methods. Prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) SUVmax values, prostate-specific antigen (PSA) and pathology parameters were recorded. PSA and SUVmax values were compared between oligometastatic/multimetastatic and D’Amico risk groups. By performing receiver operating characteristic analyses, SUVmax values in predicting oligometastatic and high-risk disease were tried to be predicted. Results: According to the D’Amico risk scoring, there was no significant difference in SUVmax values between the low-risk group and the intermediate-risk group (p=0.18). However, a significant difference was observed between the intermediate-risk group and the high-risk group (p=0.006). According to the D’Amico risk classification, the best SUVmax cut-off value that distinguishes medium risk from high risk was 7.95, and the sensitivity for this value was found to be 73% and the specificity was 86%. The cut-off SUVmax value in distinguishing between oligometastatic and multimetastasis was found to be 12.65, and its sensitivity was 77% and specificity was 68%. The area under the curve was found to be 0.735. Conclusion: PSMA-PET should be considered as a factor guiding treatment in prostate cancer. The SUVmax value of 7.95 in the distinction of high-risk prostate cancer and the SUVmax value of 12.65 in the distinction of multimetastatic prostate cancer are safe parameters that can be used in daily practice. It will achieve more successful results with more standardized studies conducted on larger populations and will be used in a more standardized way in planning treatment.

Aim: This study investigated the relationship between systemic inflammation markers in peripheral blood, 18F-FDG PET/CT staging, PET/CT visual data, and semi-quantitative values in lung cancer. Methods: The study included 76 newly diagnosed lung cancer patients who underwent 18F-FDG PET/CT for staging between 2023 and 2024. Results: A significant positive correlation was found between the maximum standardized uptake value (SUVmax) of the lung mass and the systemic immune-inflammation index (SII). However, no significant correlation was observed between the SUVmax of the lung mass and the platelet-to-lymphocyte ratio (PLR) or neutrophil-to-lymphocyte ratio (NLR). A significant positive correlation was also found between the total lesion glycolysis and metabolic tumor volume of the lung mass and the SII, NLR, and PLR. Conclusion: Our findings suggest that metabolic parameters on initial PET/CT are positively correlated with systemic inflammation markers. We propose that both factors contribute to a poorer prognosis in lung cancer and should be considered during patient follow-up. Additionally, we would like to emphasize that the possibility of an underlying malignancy should not be overlooked in patients with elevated inflammation levels, especially those admitted to the hospital for other clinical reasons.

Aim: The main molecular factors affecting the aggressiveness of breast cancer are estrogen receptor, progesterone receptor, and human epidermal growth factor-2. We wanted to study how molecular subtypes make a difference in tumor metabolism and staging in 18F-FDG PET/CT. Materials and Methods: Between 2023 and 2024, 110 patients with breast cancer who presented to our nuclear medicine clinic for staging were included in the study. Results: There was no statistically significant correlation between the molecular classification of the patients and the SUVmax levels of the primary breast tumor (p = 0.055). There was a significant correlation between breast molecular types and the presence of lymph node metastasis (p = 0.032). Triple-negative and Luminal B type patients had a higher risk of lymph node metastasis compared to other molecular subtypes. There was a significant correlation between Ki67 proliferation and molecular subtypes (p = 0.000). We also found a significant correlation between Ki67 index and breast tumor and lymph node SUVmax levels (p = 0.000, p = 0.03). There was a significant correlation between Ki67 proliferation and the presence of lymph node metastasis (p = 0.000). Discussion: In the present study, we demonstrated that different molecular subtypes show different metabolic characteristics. We also revealed that tumor Ki67 levels cause metabolic differences, and tumors with high Ki67 levels on 18F-FDG PET/CT have an increased likelihood of lymph node metastasis. We think that Ki67 levels should be taken into consideration when interpreting lymph node positivity in these patients.

This study aims to assess the diagnostic performance of 18F-FDG PET/CT parameters for the preoperative prediction of axillary lymph node (ALN) metastasis in Luminal A-type breast cancer patients, and to investigate the net clinical benefit of combining visual analysis with quantitative metrics. We retrospectively evaluated 279 treatment-naive female patients histopathologically diagnosed with Luminal A type breast cancer who underwent 18F-FDG PET/CT for staging and subsequent ALN sampling between January 2012 and December 2025. Both visual assessment and quantitative parameters—including maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of the primary tumor, as well as axillary SUVmax and the axilla-to-primary SUVmax ratio (SUVr)—were analyzed by two nuclear medicine specialists in consensus. Diagnostic performance was measured using ROC analysis and DeLong’s test. The incremental value of the models was evaluated through Net Reclassification Improvement (NRI) and Integrated Discrimination Improvement (IDI), while clinical utility was determined via Decision Curve Analysis (DCA). ALN metastasis was confirmed in 152 (54.5

This study aimed to evaluate the accuracy and reliability of preoperative 18F-FDG PET/CT in predicting the peritoneal cancer index (PCI) in patients diagnosed with peritoneal carcinomatosis secondary to ovarian cancer. Thirty patients with ovarian cancer (FIGO stages IIIC to IV) who underwent preoperative 18F-FDG PET/CT imaging at our institution were included. The surgical peritoneal cancer index (sPCI) was statistically compared with the radiological PCI (rPCI) derived from preoperative 18F-FDG PET/CT scans. Statistical analysis revealed significantly lower predictive values for rPCI compared to sPCI (p = 0.013). Subgroup analysis demonstrated no statistically significant difference between sPCI and rPCI in patients with sPCI ≤ 10 (p = 0.096). Our findings suggest that 18F-FDG PET/CT has limited utility in predicting the peritoneal cancer index in ovarian carcinomatosis. However, it may be clinically reliable in cases where the radiological PCI is < 10.

Objectives Chronic kidney disease (CKD) is a significant health issue worldwide, leading to both cardiovascular diseases and the development of end-stage chronic kidney failure. Guidelines recommend the use of serum creatinine and glomerular filtration rate (GFR) calculations as the first step in the assessment of renal function. In this study, we aimed to assess the performance of three different creatinine-based GFR estimation formulae (Chronic Kidney Disease Epidemiology Collaboration, CKD-EPI 2021; Modification of Diet in Renal Disease, MDRD; Cockcroft-Gault, CG) by comparing them to measured GFR using technetium-99m diethylene triamine penta-acetic acid ( 99m Tc-DTPA) with dual plasma sampling, a more reliable method for GFR assessment. Methods A total of 905 patients, 433 male and 472 female, who applied for routine GFR measurement with 99m Tc-DTPA between 2012 and 2016 were included in this study. Results The median GFR value measured by 99m Tc-DTPA using dual plasma sampling was 25 mL/min/1.73 m 2 , while the formulae based on creatinine overestimated GFR. Kappa analysis showed moderate levels of agreement in classifying CKD stages. The highest discrepancies were observed in patients with normal creatinine values. Conclusions In older adults, serum creatinine levels and creatinine-based GFR estimation may not reliably reflect renal function due to age-related physiological changes such as decreased muscle mass and creatinine production. Nevertheless, our results suggest that the weight-corrected CG formula may be a suitable alternative to overcome these limitations in patients over 60 years of age when GFR cannot be determined by cystatin C or 99m Tc-DTPA.

OBJECTIVE This study aimed to investigate the relationship and prognostic value of the Gustave Roussy Immune Score (GRIm Score), quantitative 18F-FDG PET/CT parameters, and histopathological features in operable pancreatic ductal adenocarcinoma (PDAC) patients. METHODS We retrospectively analysed 18F-FDG PET/CT data, routine pre-operative blood tests (for GRIm Score), and post-surgical pathology (LVI, PNI, etc.) from 41 operable PDAC patients (2016-2024). The GRIm Score (0-3) was determined using LDH, Albumin, and NLR. Patients were categorized into low (0-1) and high (2-3) GRIm groups for statistical evaluation. RESULTS No significant correlation was found between the GRIm score and PET/CT or pathology features. Mean overall survival was 12.97 months. Patients with high GRIm scores showed significantly shorter survival (6.2 months vs. 16.7 months, p<0.001). Multivariate survival analysis confirmed that both the GRIm score (HR=10.258, p<0.001) and the presence of LVI (HR=14.899, p=0.019) were independent prognostic factors. Other parameters did not show a significant association with survival. CONCLUSION The GRIm score, easily and cost-effectively calculated from routine blood tests, holds significant and independent prognostic value in operable PDAC patients. Its independence from conventional tumor features suggests promising potential for assessing prognosis.

Background and Objectives: Neuroendocrine neoplasms are heterogeneous tumours arising from endocrine gland cells and the neuroendocrine system. Gastroenteropancreatic neuroendocrine tumours (GEP-NETs) constitute two-thirds of this tumour group. This study was aimed at investigating the relationship between histone deacetylase enzymes (HDAC) and glutamine synthetase (GS) positivity, and 68Ga-DOTATATE PET/CT data and their effect on prognosis in gastroenteropancreatic neuroendocrine tumours. Materials and Methods: Twenty-seven patients with Grade 1 and Grade 2 well-differentiated neuroendocrine tumours, diagnosed by biopsy and admitted to our nuclear medicine clinic for staging were included in the study. Results: There was no statistically significant correlation between HDAC and GS positivity in tumours and DOTATATE SUVmax value on PET/CT. There was no significant correlation between HDAC and GS positivity or negativity in the tumour and the presence or absence of metastasis on PET/CT. There was no statistically significant relationship between HDAC and GS positivity and survival. There was a statistically significant correlation between DOTATATE SUVmax value on PET/CT and survival (p = 0.039). Conclusions: According to the results of the present study, overall survival rates decreased in patients with high 68Ga-DOTATATE uptake on PET/CT and therefore, patients with high SUVmax on PET/CT should be followed closely and their prognosis may be poor. In addition, although not statistically significant, the mortality rate is higher in patients with HDAC-positive tumours compared to in patients with HDAC-negative tumours; thus, it should be kept in mind that the prognosis of such patients may also be poor. According to the results of the present study, GS levels were generally negative in NETs. In addition, there was no statistically significant relationship between GS levels and survival.

Objective: The aim of the present study was to evaluate the association of obesity and diabetes with 18F-FDG PET/CT SUVmax values and metastasis in breast cancer patients. Material and Methods: The study included 126 breast cancer patients who underwent 18F-FDG PET/CT for staging between 2023 and 2024. Results: There was no significant correlation between the presence of obesity and breast tumour SUVmax value (p=0.427). There was no significant relationship between body mass index and metastatic lymph node SUVmax and distant metastasis SUVmax (p=0.06, p=0.457). There was no significant association between the presence or absence of diabetes and distant metastasis SUVmax or lymph node metastasis SUVmax on 18F-FDG PET/CT (p=0.723, p=0.581). In our study, there was no significant difference in the 18F-FDG PET/CT findings of breast cancer patients with diabetes at the time of diagnosis compared to women without diabetes. In addition, although not statistically significant, we found that the median SUVmax values for lymph node and distant metastases were significantly higher in obese and morbidly obese patients compared to other patients. Therefore, we think that breast cancer patients should be followed up more closely in the follow-up of obese and diabetic patients, taking these conditions into consideration and patients should be advised to lose weight. Conclusion: In conclusion, although we did not find a significant association between body mass indeks and diabetes and breast cancer in our study, we think that this may be due to the small number of patients. We also found that the risk of axillary lymph node metastasis increased as breast tumor SUVmax increased and the cut-off value for breast tumor SUVmax was 5.15. We think that the presence of lymph node metastasis on PET/CT should be reported carefully, taking into account the SUVmax value.

Objective:The aim of this study was to evaluate the relationship between Galium-68 prostate-specific membrane antigen positron emission tomography combined with computed tomography (68Ga-PSMA PET/CT) quantitative parameters and patient obesity, prostate-specific antigen (PSA) levels, and metastasis type in prostate cancer. Methods:In the present study, we included 112 patients diagnosed with prostate cancer between 2020 and 2024. These patients underwent 688Ga-PSMA PET/CT imaging for staging purposes, with locoregional or distant metastasis detected in the imaging results. Results:No significant correlation was observed between body mass index (BMI) classification and prostate gland maximum standard uptake values (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG), standardized uptake value lean (SUL), or SUVmean values. A weak inverse correlation was found between BMI and PSA levels (p=0.08, r=-0.248), with PSA values decreasing as patient weight increased. The presence of locoregional disease or distant metastasis was not significantly associated with prostate gland SUVmax, MTV, TLG, SUVmean, or SUL values (p=0.25; 0.667; 0.667; 0.244; 0.126, respectively). However, a significant association was detected between PSA levels and distant metastases or locoregional disease (p=0.02), with higher PSA values observed in patients with distant metastases compared to those with locoregional disease. Additionally, significant correlations were found between the D'Amico risk classification and the prostate gland SUVmax, TLG, SUL, and SUVmean values (p=0.035, 0.037, 0.012, 0.028, respectively). Conclusion:PSA levels may assist in estimating whether metastases are local or distant. However, due to the weak inverse correlation between BMI and PSA, it is important that low PSA levels may not necessarily indicate localized disease during clinical evaluation.

Objectives: This study aimed to evaluate the relationship between the degree of bone marrow involvement, hematological parameters, and 18 F-fluorodeoxyglucose ( 18 F-FDG)-positron emission tomography/computed tomography (PET/CT) data in patients diagnosed with multiple myeloma.Methods: A total of 71 patients [19 females, 52 males, mean age 67 (36-83) years] who were diagnosed with multiple myeloma between 2014 and 2021, had not received any treatment yet, and underwent 18 F-FDG-PET/CT for staging were included in the study.Results: No significant correlation was observed between bone marrow standardized uptake value (SUV) max and plasma cell infiltration (p=0.07).However, we found that patients with visually increased bone marrow counts also had higher plasma cell infiltration rates (p=0.037).No significant correlation was found between plasma cell infiltration rates and bone marrow SUV max and systemic inflammatory index (SII) (p=0.187 and p=0.446, respectively).However, there was a significant correlation between the SUV max of lytic lesions showing increased 18 F-FDG uptake in bone and SII (p=0.025,r=0.330). Conclusion:We believe that 18 F-FDG PET/CT may be an advantage over bone marrow biopsy in the diagnosis and evaluation of Multiple Myeloma recurrence and may prevent repeated bone marrow biopsies.

Objectives Forkhead box (FOX) transcription factors and long non-coding RNAs (lncRNAs) localize within tumor cell nuclei in various cancers, suggesting their involvement in transcriptional regulation. This study aimed to investigate expression changes of FOX family members and selected lncRNAs to explore their potential regulatory roles in differentiated thyroid cancer (DTC). Methods Expression levels of FOX genes and lncRNAs were analyzed using RT-PCR, and protein levels were measured via ELISA in patients diagnosed with DTC who received radioactive iodine (RAI) therapy. Results RT-PCR analysis revealed significant differences in FOXO1 and HOXA11-AS expression before and after RAI therapy (p<0.05). FOXO3 , FOXP1 , FOXP2 , and CASC21 showed significant expression differences in pre-RAI samples, while MEG3 and KCNQ1OT1 differed significantly post-RAI (p<0.05). Moreover, strong correlations were identified between FOXO3 , FOXP2 , and key lncRNAs including MEG3 , KCNQ1OT1 , CASC21 , and HOXA11-AS (p<0.05). ELISA results showed a significant change in FOXP1 protein levels, and TSH and Tg levels differed significantly across treatment stages (p<0.05). CASC21 exhibited the highest AUC in ROC analysis. Conclusions Despite the limited sample size, the findings suggest the potential of these genes, particularly CASC21, as biomarkers in DTC. These results may contribute to enhancing RAI therapy efficacy and advancing personalized treatment approaches.

Introduction: This study aimed to evaluate the relationship between pathological and clinical risk classifications in newly diagnosed prostate cancer patients, and 68Ga-PSMA PET/CT data and serum Prostate Specific Antigen (PSA) values. Method: A total of 203 patients who were diagnosed with prostate cancer between 2019 and 2023, who had not yet received treatment and who underwent 68Ga-PSMA PET/CT for staging purposes were included in this study. Results: There was a substantial correlation between D’Amico risk classification, Gleason score, ISUP classification, and the presence or absence of metastasis (p < 0.0001). The median SUVmax value of the prostate gland and the D’Amico risk classification were statistically significantly correlated. (p < 0.0001). There was a statistically significant correlation between the ISUP classification and the PSA value and prostate gland SUVmax value (p < 0.0001). There was a significant correlation between the median SUVmax values of the prostate gland at the time of diagnosis and the patients with and without metastases (p < 0.0001). According to the data obtained from ROC analysis, patients with prostate gland SUVmax values of 8.75 and above were found to have a high probability of metastasis with a sensitivity of 78.9% and a specificity of 59.05%. Conclusion: Our study showed that 68Ga-PSMA PET/CT is a highly effective method for staging newly diagnosed high-risk prostate cancer. The probability of metastasis was found to be dramatically increased in Gleason 8 and above. According to D’Amico risk classification, metastasis was detected in at least half of high-risk patients. Since the sensitivity of metastasis was 78.9% in patients with prostate gland SUVmax value above 8.75, we think that these patients should be carefully reported in terms of metastasis.

Objectives:This study aimed to evaluate the relationship between mobile phone usage and miRNA-574-5p and miRNA-30C-5p levels in patients diagnosed with differentiated thyroid cancer (DTC).Methods:Fifty patients diagnosed with DTC and 50 healthy volunteers were included in the study. miRNA-574-5p and miRNA-30C-5p gene expression levels in the blood of all subjects were analyzed by real time-polymerase chain reaction, and a questionnaire including various questions was administered to both groups.Results:Although there was a 7.60-fold increase in miRNA-30C-5p gene expression levels in the patient group compared with the control group, it was not found to be statistically significant. Considering the miRNA-574-5p gene expression levels, although there was a 2.96-fold increase in the patient group compared with the control group, no significant relationship was found. In our study, 85% of our patients were using mobile phones with internet access, whereas 98% of our healthy volunteers were using mobile phones (p<0.05). While 53.5% of the patients had their mobile phones with them while they were sleeping, this rate was 83.7% in healthy volunteers (p<0.05). However, 93.9% of the healthy volunteers did not have a Wi-Fi device in their bedrooms, and this rate was 75% in the patient group (p<0.05).Conclusion:Although miRNA-30C-5p and miRNA-574-5p gene expression levels were higher in patients than in healthy volunteers, the differences were not statistically significant. Although there was no significant difference in miRNA levels, we believe that due to the higher rate of Wi-Fi device presence in bedrooms in patients compared with healthy volunteers, the effects of electromagnetic radiation on the thyroid can be reduced by paying attention to this simple change.

The aim of this study was to evaluate the sensitivity of 18F-FDG (fluorodeoxyglucose) PET/CT (positron emission tomography / computed tomography) imaging performed for primary staging prior to surgery performed with the low anterior resection technique in detecting the presence of lymph node metastases detected in the mesorectal area. In our retrospective study, 44 patients who were operated for colorectal cancer in our Surgical Oncology Department between June 15, 2015 and June 15, 2020 and who underwent 18F-FDG PET/CT for preoperative staging were included. The demographic data of the patients were obtained from the records were taken during routine clinical interrogations before both surgery and PET/CT scan, and from the automation system records of our hospital. While 12 (27.3%) of the patients had vascular invasion, 32 (72.7%) did not. While 15 (34.1%) of the patients had perineural invasion, 29 (65.9%) did not. Histopathologically, the rates of lymph node metastasis were high in patients with vascular invasion and perineural invasion (p=0.005 and p=0.012, respectively). There was no significant relationship between the SUVmax value of the primary tumor in PET/CT and the presence/absence of lymph node metastasis histopathologically determined (p=0.405). The median tumor size of the primary mass lesion was 4 cm (15-150 mm). No significant correlation was found between tumor size and presence/absence of lymph node metastasis (p=0.587). Sensitivity of CT is 68.7%, specificity 44.4%, accuracy 55.8%, positive predictive value 52.3%, negative the predictive value was 61.5%; whereas the sensitivity of 18F-FDG PET/CT was found to be 78.9%, specificity 50%, accuracy 63.6%, positive predictive value 55.5%, negative predictive value 76.4%. In conclusion, despite advanced imaging techniques, it will not be possible to be sure of the presence/absence of metastatic lymph nodes without radical surgery. We think that PET/CT imaging has also an important place in determining distant lymph node metastases other than regional lymph node spread.

Introduction: Obesity and aggressive prostate cancer are two important clinical conditions because of the prevalence and obesity increases the aggressiveness of prostate cancer. In this study, our aim was to investigate obesity rates at the time of diagnosis in patients who underwent Ga-68 PSMA PET/CT. Materials and methods: 104 patients with newly diagnosed prostate cancer who underwent Ga-68 PSMA PET/CT between 2021 and 2022 for staging were included in this study. The patients' height and weight, pathology results and PSA values, which were recorded routinely before PET/CT, were obtained from Nuclear Medicine patient files. The formula [mass (kg) / height2 (m)] was used to calculate the body mass index (BMI). According to the PSA values and Gleason score of the patients, intermediate and high-risk patients were included in the study. Results: The median age of the patients was 70.5 (range:40-87 yrs) at the time of diagnosis and 67 (64.4 %) patients had metastases at the time of diagnosis. Of the patients, 15 (14.4%) were in the intermediate risk group and 89 (85.6%) were in the high risk group. Of the patients, 33 (31.7%) were normal weight, 45 (43.3%) were overweight, and 26 (25%) were obese. There was no significant difference between prostate cancer risk groups and BMI (p=0.126) Conclusion: As a result, the weight of the majority of the patients in our study was above normal. However, there was no significant difference between overweight and obese and prostate cancer risk groups. However, considering all the literature information, being overweight increases the risk of cancer, and attention should be paid to dietary habits.

Papillary thyroid cancer (PTC) is the most common type of thyroid cancer, and its inciden ce continues to increase.Multifocality is common in PTC, and it has been suggested in many studies that multifocality may be associated with poor prognosis.In this study, data of patients followed with multifocal PTC were evaluated.Following the approval of the local ethics committee, the data of patients who received total thyroidectomy and subsequent radioactive iodine (RAI) treatment for thyroid cancer between 2012 and 2020 were evaluated.Multifocality was detected in 142 (19.88%) of the 714 PTC patients studied.The rate of multifocality among PTC patients was 3.29% in 2012, 7.2% in 2013, 10.1% in 2014, 10.5% in 2015, 38.15% in 2016, 31.6% in 2017, 33.33% in 2018, 32.58% in 2019 and 22.22% in 2020.Of these patients, 52.1% had 2 foci, 20.4% had 3 foc i, 15.5% had 4 foci, and 12% had 5 or more foci.Multifocality was observed in the right and left lobe in 54.2% of the patients, the right lobe in 21.1% of the patients and t he left lobe in 12.7% of the patients.Multifocality was not detected in the isthm us only.It was found that as the number of tumor foci increased, differentiation decreased.It was observed that multifocality was more common in microcarcinomas.In our clinic, it has been observed that the rate of multifocal PTC has increased in recent years.This significant increase may be the result of morphological changes as well as improvements in diagnosis and treatment.