目的 观察补肾益气法联合来得时治疗糖尿病肾病的临床疗效.方法 选择符合诊断标准的62例患者,随机分为治疗组和对照组,治疗组在采用常规治疗基础上联合口服补肾益气中药及皮下注射来得时(甘精胰岛素),对照组采用常规治疗联合来得时,共6个月,观察治疗前后临床症状及24h尿蛋白定量的变化.结果 2组治疗后临床主要症状积分均明显降低,与本组治疗前比较差异有统计学意义(P＜0.05),2组均可改善糖尿病肾病临床症状,2组治疗后临床主要症状积分比较差异有统计学意义(P＜0.05),治疗组在改善糖尿病肾病患者临床症状方面优于对照组;治疗组治疗后24h尿蛋白定量与治疗前比较有显著下降,差异有统计学意义(P＜0.05),与对照组治疗后比较差异亦有统计学意义(P＜0.05);治疗组总有效率为87.09％,对照组为74.19％,2组比较差异有统计学意义(P＜0.05).结论 补肾益气法联合来得时对糖尿病肾病有较好的疗效.

目的：观察补肾益气法联合来得时的疗法对糖尿病肾病治疗的临床效果．方法：选取符合标准的62例患者随机分成两组，治疗组与对照组．治疗组在给予常规治疗基础上同时服用补肾益气中药及皮下注射来得时（甘精胰岛素），对照组采用西药常规对症治疗，共6个月．观察治疗前后两组24 h尿蛋白、血尿素氮、血肌酐、血脂等变化情况．结果：治疗组与对照组治疗后各项指标均有改善（P＜0．05）．但治疗组比对照组改善更为明显（P＜0．05）．结论：补肾益气法联合来得时治疗糖尿病肾病有较好的疗效．

目的：通过观察补肾益气法联合来得时治疗糖尿病肾病的临床疗效。总结此法治疗糖尿病肾病的临证经验。

OBJECTIVE:To study the association between reduced folate carrier gene (RFC1 A80G) polymorphism and the risk for child with neural tube defects (NTDs), and to provide epidemiological evidence for the existence of NTDs genetic marker.METHODS:RFC1 (A80G) genotypes were detected using RFLP-PCR for blood DNA of 104 families with NTDs-affected children and 100 control families with no history of child-affected birth defects. Case-control study and transmission/disequilibrium test(TDT) for the RFC1 genotype of NTDs pedigree were carried out.RESULTS:The G allele frequency of children with NTDs was higher than that of controls when compared to A allele( OR = 1. 64, 95% CI :1.08-2.49). The offspring of the GG genotype were associated with a 2.56-fold increased risk of NTDs when compared to the AA genotype (OR = 2.56, 95% CI: 1.04-6.36) in our study population. There was evidence of association between G allele and the risk of parent having a child with NTDs (OR = 1.56, 95% CI: 1.07-2.28) in the TDT analysis.CONCLUSION:Our findings indicated that there was potential association between offspring RFC1 GG genotype and the risk of NTDs, and the G allele was a possible susceptible gene marker for an increased NTDs risk in the Chinese population.

Objective To describe the epidemiological characteristics of oral clefts in 5 counties of Hebei Province of China, between 1993 and 1996. Methods Detailed data were obtained through the Birth Defects Surveillance System that was established in 1992. The study population comprised the total live and stillbirths (with a gestational age of at least 20 weeks) in the counties between 1993 and 1996. Birth prevalence of oral clefts (including cleft palate alone, cleft lip+ /-cleft palate) was calculated for specific birth populations. Results In the period of 1993-1996, the overall prevalence of oral clefts was 2. 080 total births, and the rates of cleft palate and cleft lip +/-cleft palate were 0. 300 and 1. 780 , respectively. The highest rate (3. 350 ) of oral clefts was seen in Yuanshi county, and the lowest (1. 660 )in Xianghe county. the highest birth prevalence (2. 700 ) of oral clefts was in the year 1993, and the lowest (1. 680 ) in 1995. There was no significant seasonal variation of oral clefts. The overall male/female ratio was 1. 38 : 1. The birth prevalence rates of cleft lip +/-cleft palate for male and female were 2. 080 and 1. 430 respectively (X2=4.14,P0. 05). Conclusion The birth prevalence of oral clefts in the 5 counties of Hebei Province was persistently high, and sex differences existed during the period of between 1993 and 1996. Possible environmental factors and indicated and differences in susceptibility exist between two sexes.

目的：观察益肾活血排毒法对慢性肾功能衰竭患者BUN、Scr、Ccr血脂、血液粘稠度、血色素的改变验证其对慢性肾功能衰竭治疗作用及疗效。方法：口服与灌肠和外敷相结合治疗，以尿毒清颗粒对照。结果：总有效率为98.75%。结论：多渠道给药治疗慢性肾功衰竭可明显改善症状，提高有效率。