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研发艾滋病疫苗对于预防HIV的传播具有重大意义。本实验室坚持致力于研发预防性HIV疫苗与治疗性HIV疫苗。参与与主持国家传染病重大专项、国家自然科学基金等科研项目。近5年在本领域的国际学术杂志,如Journal of Virology, Vaccine,AIDS & Human Retrovirus, PloS One等发表多篇论文,申请国际/国内专利多项。
以猴艾滋病疫苗为模型,研发了克服抗腺病毒抗体的新技术,提升了相关生物制品的使用效率和范围(Journal of Virology, 2012)
率先研发了预防黏膜途径感染猴艾滋病毒(SIV)的新型疫苗,发现其激发的效应记忆性CD8+ T细胞免疫与保护效果呈正相关,为相关HIV疫苗进入临床试验奠定了基础(Journal of Virology, 2013)
发现了通过阻断PD-1 及Tim-3的免疫负调节信号通路可显著提升艾滋病疫苗的CD8+ T细胞免疫应答水平,为HIV疫苗佐剂设计提供了新思路(Human Vaccine & Immunother. 2013)
揭示了机体可利用自噬机制对内源性蛋白(包括HIV抗原)进行MHCⅡ类分子的抗原提呈,从而提升了HIV疫苗CD4+T细胞免疫应答,对新型疫苗研发有重要启示意义(PloS One, 2014)
以猴艾滋病疫苗为模型,研发了克服抗腺病毒抗体的新技术,提升了相关生物制品的使用效率和范围(Journal of Virology, 2012)
率先研发了预防黏膜途径感染猴艾滋病毒(SIV)的新型疫苗,发现其激发的效应记忆性CD8+ T细胞免疫与保护效果呈正相关,为相关HIV疫苗进入临床试验奠定了基础(Journal of Virology, 2013)
发现了通过阻断PD-1 及Tim-3的免疫负调节信号通路可显著提升艾滋病疫苗的CD8+ T细胞免疫应答水平,为HIV疫苗佐剂设计提供了新思路(Human Vaccine & Immunother. 2013)
揭示了机体可利用自噬机制对内源性蛋白(包括HIV抗原)进行MHCⅡ类分子的抗原提呈,从而提升了HIV疫苗CD4+T细胞免疫应答,对新型疫苗研发有重要启示意义(PloS One, 2014)
Research Interests
Papers共 260 篇Author StatisticsCo-AuthorSimilar Experts
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CNS neuroscience & therapeuticsno. 5 (2024): e14720-e14720
Xinglong Liu,Zhengfeng Li,Xiao Li,Xiaoyan Zhang,Yali Zheng,Wan Su, Ying Feng,Yutong Liu, Weixuan Wu,Xikui Sun,Nana Wang,Xianmiao Ye,Zhichao Zhou,Wenkuan Liu,Jun He, Wei Wang,Linbing Qu,Rong Zhou,Ling Chen,Liqiang Feng
EMERGING MICROBES & INFECTIONSno. 1 (2024): 2307513-2307513
EXPERT REVIEW OF VACCINESno. 1 (2024): 362-370
Baoqing Sun,Zhilong Chen, Bo Feng, Si Chen, Shilin Feng, Qian Wang,Xuefeng Niu,Zhengyuan Zhang,Peiyan Zheng, Ming Lin,Jia Luo, Yingxian Pan,Suhua Guan,Nanshan Zhong,Ling Chen
Frontiers in microbiology (2024)
Min Wu, Qian Wang,Hengchun Li,Jiawang Tao, Zhi Wang,Shengnan Zhang,Longhui Chen,Pingchao Li,Ling Chen,Linbing Qu
The FASEB journalno. 9 (2024)
Jian-Bo Cao, Shu-Tong Zhu, Xiao-Shan Huang, Xing-Yuan Wang,Meng-Li Wu, Xin Li,Feng-Liang Liu,Ling Chen,Yong-Tang Zheng,Jian-Hua Wang
Virologica Sinica/Virologica sinica (2024)
Emerging microbes & infectionsno. 1 (2024)
Harold Marcotte,Yunlong Cao,Fanglei Zuo,Luca Simonelli,Jose Camilla Sammartino,Mattia Pedotti,Rui Sun,Irene Cassaniti,Marie Hagbom,Antonio Piralla,Jinxuan Yang,Likun Du,Elena Percivalle,Federico Bertoglio,Maren Schubert,Hassan Abolhassani,Natalia Sherina,Concetta Guerra,Stephan Borte,Nima Rezaei,Makiko Kumagai-Braesch,Yintong Xue, Chen Su, Qihong Yan, Ping He,Caroline Groenwall,Lars Klareskog,Luigi Calzolai,Andrea Cavalli,Qiao Wang,Davide F. Robbiani,Michael Hust,Zhengli Shi,Liqiang Feng,Lennart Svensson,Ling Chen,Linlin Bao,Fausto Baldanti,Junyu Xiao,Chuan Qin,Lennart Hammarstrom,Xinglou Yang,Luca Varani,Xiaoliang Sunney Xie,Qiang Pan-Hammarstrom
Proceedings of the National Academy of Sciences of the United States of Americano. 3 (2024)
Ziyu Wen,Pingchao Li,Yue Yuan,Congcong Wang,Minchao Li, Haohang Wang, Minjuan Shi,Yizi He,Mingting Cui,Ling Chen,Caijun Sun
biorxiv(2024)
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Author Statistics
#Papers: 259
#Citation: 9224
H-Index: 44
G-Index: 92
Sociability: 7
Diversity: 4
Activity: 158
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