基本信息
浏览量:1
职业迁徙
个人简介
My Research
KEYWORDS
immunology, cancer, autoimmunity, inflammation, microbiota
SUMMARY
Currently my laboratory is focused on the following questions: 1. How do Th17 cells promote chronic inflammation? We are using several animal model of chronic inflammation that we developed in the lab (COPD and Psoriatic Arthritis) to understand the genesis of tissue specific inflammation. In particular, we are examining the role of antigen stimulation and environmental triggers (namely microbiota and microbial metabolites) in potentiating Th17 mediated chronic inflammation. 2. What is the role of antigen stimulation and microbiota in malignant T cell transformation? We are using a newly established animal model of CTCL and our state of the art gnotobiotic facility to complement our studies of patient biospecimens to address the role of T cell Ag receptor and microbial antigens in the malignant transformation of T lymphocytes. Our focus is on Cutaneous T Cell Lymphoma (CTCL), an enigmatic malignancy of T lymphocytes, characterized by the striking dermal tropism of the malignant cells. 3. What is the role of tumor intrinsic metabolic changes in the suppression of the cancer-specific immune responses? We are taking advantage of our unique access to patient biospecimens and our cutting-edge mouse genetics to dissect how tumors subvert immune surveillance by changing their metabolic profile. Our focus is currently on lung cancer. 4. What is the role of non-coding RNAs in lymphocyte development and function? The emphasis of this project is to both explore the role of individual miRNAs in maintaining lymphoid identity, survival and proliferation; and to understand the contribution of RNAi to Ig locus accessibility during V(D)J recombination, somatic hypermutation and class switch recombination.
KEYWORDS
immunology, cancer, autoimmunity, inflammation, microbiota
SUMMARY
Currently my laboratory is focused on the following questions: 1. How do Th17 cells promote chronic inflammation? We are using several animal model of chronic inflammation that we developed in the lab (COPD and Psoriatic Arthritis) to understand the genesis of tissue specific inflammation. In particular, we are examining the role of antigen stimulation and environmental triggers (namely microbiota and microbial metabolites) in potentiating Th17 mediated chronic inflammation. 2. What is the role of antigen stimulation and microbiota in malignant T cell transformation? We are using a newly established animal model of CTCL and our state of the art gnotobiotic facility to complement our studies of patient biospecimens to address the role of T cell Ag receptor and microbial antigens in the malignant transformation of T lymphocytes. Our focus is on Cutaneous T Cell Lymphoma (CTCL), an enigmatic malignancy of T lymphocytes, characterized by the striking dermal tropism of the malignant cells. 3. What is the role of tumor intrinsic metabolic changes in the suppression of the cancer-specific immune responses? We are taking advantage of our unique access to patient biospecimens and our cutting-edge mouse genetics to dissect how tumors subvert immune surveillance by changing their metabolic profile. Our focus is currently on lung cancer. 4. What is the role of non-coding RNAs in lymphocyte development and function? The emphasis of this project is to both explore the role of individual miRNAs in maintaining lymphoid identity, survival and proliferation; and to understand the contribution of RNAi to Ig locus accessibility during V(D)J recombination, somatic hypermutation and class switch recombination.
研究兴趣
论文共 157 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Ray Pillai,Sarah E LeBoeuf,Yuan Hao, Connie New, Jenna L E Blum,Ali Rashidfarrokhi,Shih Ming Huang,Christian Bahamon, Warren L Wu, Burcu Karadal-Ferrena,Alberto Herrera,Ellie Ivanova,
Science advancesno. 13 (2024): eadm9859-eadm9859
Katharine Lu Yang, Briana J Mullins,Alannah Lejeune,Ellie Ivanova,Jong Shin, Sofia Bajwa,Richard Possemato,Ken Cadwell,Jose U Scher,Sergei B Koralov
Arthritis & rheumatology (Hoboken, N.J.)no. 4 (2024): 647-659
Blood (2024)
Timothy C Borbet, Kimberly Zaldaña,Anastasia-Maria Zavitsanou,Marcus J Hines, Sofia Bajwa, Tate Morrison, Thomas Boehringer, Victoria M Hallisey,Ken Cadwell,Sergei B Koralov
bioRxiv : the preprint server for biology (2023)
引用0浏览0WOS引用
0
0
American Journal of Respiratory and Critical Care Medicineno. 10 (2023): 1101-1114
引用0浏览0引用
0
0
Ray Pillai,Sarah LeBoeuf,Ali Rashidfarrokhi, Shih Ming Huang,Triantafyllia Karakousi, Anastasia-Maria Zavitsanou, Warren Wu,Volkan Sayin,Robert Wild,Sergei Koralov,Thales Papagiannakopoulos
CANCER RESEARCHno. 7 (2023)
引用0浏览0引用
0
0
Journal of Immunologyno. 1 (2023): 67.31-67.31
The Journal of investigative dermatologyno. 9 (2023): 1757-1768.e3
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn