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Our lab is focused on understanding the genetic changes that drive the development and progression of hematologic malignancies like acute myeloid leukemia and myelodysplastic syndromes. Our goal is to translate our discoveries into clinically meaningful improvements in how we care for patients with these disorders.
Our prior work helped characterize the range of genetic alterations that exist in patients with myelodysplastic syndromes (MDS). We studied bone marrow sample from over 400 patients with these disorders and examined them for mutations in over 20 recurrently mutated genes. We learned about the relative frequency of these mutations, how they can overlap with each other, and how they may better classify molecular subtypes of MDS. We demonstrated that mutations in several genes are associated with clinical features seen in patients with MDS, potentially explaining much of the heterogeneity associated with this disease. Most importantly, we identified mutations in several genes, that when present, are associated with a poorer prognosis than would otherwise be predicted using standard clinical scoring systems. This has helped accelerate the drive to include tumor sequencing in the standard evaluation of patients with MDS.
Currently we are investigating how acquired mutations in the diseased cells from patients with myelodysplastic syndromes are associated with their response to treatment with drugs like azacitidine and decitabine. We hope to discover genes that physicians can test for mutations in order to select the best treatment options for their patients with MDS. These studies should also give us insight into the mechanisms of drug resistance and how we may be able to overcome them.
In addition, we are interested in the functional consequence of the mutations we have characterized in patients with MDS. For example, we are studying how mutations in the EZH2 gene, which are associated with a poor prognosis, might affect the function neutrophils in patients with these abnormalities.
Going forward, we plan to implement clinical sequencing of bone marrow specimens from patients with MDS and related hematologic malignancies. Our plan is work out how best to use this information to personalize the choice of therapy and overall care of our patients with these disorders.
Our prior work helped characterize the range of genetic alterations that exist in patients with myelodysplastic syndromes (MDS). We studied bone marrow sample from over 400 patients with these disorders and examined them for mutations in over 20 recurrently mutated genes. We learned about the relative frequency of these mutations, how they can overlap with each other, and how they may better classify molecular subtypes of MDS. We demonstrated that mutations in several genes are associated with clinical features seen in patients with MDS, potentially explaining much of the heterogeneity associated with this disease. Most importantly, we identified mutations in several genes, that when present, are associated with a poorer prognosis than would otherwise be predicted using standard clinical scoring systems. This has helped accelerate the drive to include tumor sequencing in the standard evaluation of patients with MDS.
Currently we are investigating how acquired mutations in the diseased cells from patients with myelodysplastic syndromes are associated with their response to treatment with drugs like azacitidine and decitabine. We hope to discover genes that physicians can test for mutations in order to select the best treatment options for their patients with MDS. These studies should also give us insight into the mechanisms of drug resistance and how we may be able to overcome them.
In addition, we are interested in the functional consequence of the mutations we have characterized in patients with MDS. For example, we are studying how mutations in the EZH2 gene, which are associated with a poor prognosis, might affect the function neutrophils in patients with these abnormalities.
Going forward, we plan to implement clinical sequencing of bone marrow specimens from patients with MDS and related hematologic malignancies. Our plan is work out how best to use this information to personalize the choice of therapy and overall care of our patients with these disorders.
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论文共 169 篇作者统计合作学者相似作者
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Fabio Efficace,Rena Buckstein,Gregory A. Abel,Johannes M. Giesinger,Pierre Fenaux,Jan Philipp Bewersdorf,Andrew M. Brunner,Rafael Bejar,Uma Borate,Amy E. DeZern,Peter Greenberg,Gail J. Roboz,Michael R. Savona,Francesco Sparano,Jacqueline Boultwood,Rami Komrokji,David A. Sallman,Zhuoer Xie,Guillermo Sanz,Hetty E. Carraway,Justin Taylor,Stephen D. Nimer,Matteo Giovanni Della Porta,Valeria Santini,Maximilian Stahl,Uwe Platzbecker,Mikkael A. Sekeres,Amer M. Zeidan
HEMASPHEREno. 5 (2024)
Amy E. DeZern,Johannes Goll,Travis L Jensen,Sridhar Nonavinkere Srivatsan,Nancy K Gillis,Gregory A Abel,Eric Padron,H Joachim Deeg,Tareq Al Baghdadi,Jane Jijun Liu,Rami S Komrokji,Steven D Gore,Wael Saber,Rafael Bejar,Matthew J Walter,R Coleman Lindsley,Seth Sherman,Nancy DiFronzo, Mikkael A Sekeres
Blood Neoplasiapp.100026, (2024)
Fnu Aakash,Savanah D. Gisriel,Amer M. Zeidan,John M. Bennett,Rafael Bejar, Jan Philipp Bewersdorf,Uma M. Borate,Jacqueline Boultwood, Andrew M. Brunner,Rena Buckstein,Hetty Carraway,Jane E. Churpek,Naval G. Daver, Amy E. DeZern,Fabio Efficace, Pierre Fenaux, Maria E. Figueroa, Guillero Garcia-Manero,Steven D. Gore, Peter L. Greenberg
Modern Pathologypp.100615, (2024)
Maximilian Stahl,Jan Philipp Bewersdorf,Zhuoer Xie,Matteo Giovanni Della Porta,Rami Komrokji,Mina L Xu,Omar Abdel-Wahab, Justin Taylor,David P Steensma,Daniel T Starczynowski,Mikkael A Sekeres,Guillermo Sanz,David A Sallman,Gail J Roboz,Uwe Platzbecker,Mrinal M Patnaik,Eric Padron,Olatoyosi Odenike,Stephen D Nimer,Aziz Nazha,Ravi Majeti,Sanam Loghavi,Richard F Little,Alan F List,Tae Kon Kim,Christopher S Hourigan,Robert P Hasserjian,Stephanie Halene,Elizabeth A Griffiths,Steven D Gore,Peter Greenberg,Maria E Figueroa,Pierre Fenaux,Fabio Efficace,Amy E DeZern,Naval G Daver,Jane E Churpek,Hetty E Carraway,Rena Buckstein,Andrew M Brunner,Jacqueline Boultwood,Uma Borate,Rafael Bejar,John M Bennett,Andrew H Wei,Valeria Santini,Michael R Savona,Amer M Zeidan
Jan Philipp Bewersdorf,Zhuoer Xie,Rafael Bejar,Uma Borate,Jacqueline Boultwood,Andrew M Brunner,Rena Buckstein,Hetty E Carraway,Jane E Churpek,Naval G Daver,Matteo Giovanni Della Porta,Amy E DeZern,Pierre Fenaux,Maria E Figueroa,Steven D Gore,Elizabeth A Griffiths,Stephanie Halene,Robert P Hasserjian,Christopher S Hourigan,Tae Kon Kim,Rami Komrokji,Vijay K Kuchroo,Alan F List,Sanam Loghavi,Ravindra Majeti,Olatoyosi Odenike,Mrinal M Patnaik,Uwe Platzbecker,Gail J Roboz,David A Sallman,Valeria Santini,Guillermo Sanz,Mikkael A Sekeres,Maximilian Stahl,Daniel T Starczynowski,David P Steensma, Justin Taylor,Omar Abdel-Wahab,Mina L Xu,Michael R Savona,Andrew H Wei,Amer M Zeidan
Blood reviews (2023): 101072-101072
Maria Sirenko,Elsa Bernard,Maria Creignou,Dylan Domenico,Andrea Farina,Juan E. Arango Ossa,Olivier Kosmider,Robert Hasserjian,Martin Jadersten,Ulrich Germing,Guillermo Sanz,Arjan A. van de Loosdrecht,Carmelo Gurnari,Matilde Yung Follo,Felicitas Thol,Lurdes Zamora,Andrea Pellagatti,Harold K. Elias,Detlef Haase,Christina Ganster,Lionel Ades,Magnus Tobiasson,Laura Palomo,Matteo Giovanni Della Porta,Kety Huberman,Pierre Fenaux,Monika Belickova,Michael R. Savona,Virginia M. Klimek,Fabio P. S. Santos,Jacqueline Boultwood,Ioannis Kotsianidis,Valeria Santini,Francesc Sole,Uwe Platzbecker,Michael Heuser,Peter Valent,Carlo Finelli,Maria Teresa Voso,Lee-Yung Shih,Seishi Ogawa,Michaela Fontenay,Joop H. Jansen,Jose Cervera,Benjamin L. Ebert,Rafael Bejar,Peter L. Greenberg,Norbert Gattermann,Luca Malcovati,Mario Cazzola,David B. Beck,Eva Hellstrom Lindberg,Elli Papaemmanuil
Rami S. Komrokji,Somedeb Ball,Giulia Maggioni,Erica Travaglino,Najla Al Ali,Pierre Fenaux,Uwe Platzbecker,Valeria Santini,María Díez‐Campelo,Torsten Haferlach,Avani M Singh,Akriti G Jain,Luis E. Aguirre,Sara Tinsley,Zaker Schwabkey,Onyee Chan,Zhuoer Xie,Andrew M. Brunner,Andrew Kuykendall,John M. Bennett,Rena Buckstein,Rafael Bejar,Jan Philipp Bewersdorf,Hetty E. Carraway,Amy E. DeZern,Elizabeth A. Griffiths,Stephanie Halene,Robert P. Hasserjian,Sanam Loghavi,Olatoyosi Odenike,Mrinal M. Patnaik,Gail J. Roboz,Maximillian Stahl,Mikkael A. Sekeres,David P. Steensma,Michael R. Savona, Justin Taylor,Mina L. Xu,Kendra Sweet,Jeffrey E. Lancet,Alan F. List,Eric Padron,David A. Sallman,Amer M. Zeidan,Matteo Giovanni Della Porta
HemaSphereno. S3 (2023): e616260d-e616260d
Elsa Bernard,Robert Hasserjian,Peter L. Greenberg,Juan E. Arango Ossa,Maria Creignou,Yasuhito Nannya,Heinz Tuechler,Juan S. Medina-Martinez,Max F. Levine,Martin Jadersten,Ulrich Germing,Guillermo Sanz,Arjan A. van de Loosdrecht,Olivier Kosmider,Matilde Yung Follo,Felicitas Thol,Lurdes Zamora,Ronald Feitosa Pinheiro,Andrea Pellagatti,Harold K. Elias,Detlef Haase,Maria Sirenko,Christina Ganster,Lionel Ades,Magnus Tobiasson,Laura Palomo,Matteo Giovanni Della Porta,Pierre Fenaux,Monika Belickova,Michael R. Savona,Virginia M. Klimek,Fabio P. S. Santos,Jacqueline Boultwood,Ioannis Kotsianidis,Valeria Santini,Francesc Sole,Uwe Platzbecker,Michael Heuser,Peter Valent,Carlo Finelli,Maria Teresa Voso,Lee-Yung Shih,Michaela Fontenay,Joop H. Jansen,Jose Cervera,Norbert Gattermann,Benjamin L. Ebert,Rafael Bejar,Luca Malcovati,Mario Cazzola,Seishi Ogawa,Eva Hellstrom Lindberg,Elli Papaemmanuil
Bloodno. Supplement 1 (2023): 997-997
Maximilian Stahl, Jan Philipp Bewersdorf,Zhuoer Xie,Matteo Giovanni Della Porta,Rami Komrokji,Mina L. Xu,Omar Abdel-Wahab,Justin Taylor,David P. Steensma,Daniel T. Starczynowski,Mikkael A. Sekeres,Guillermo Sanz,David A. Sallman,Gail J. Roboz,Uwe Platzbecker,Mrinal M. Patnaik,Eric Padron,Olatoyosi Odenike, Stephen D. Nimer,Aziz Nazha,Ravi Majeti,Sanam Loghavi, Richard F. Little,Alan F. List,Tae Kon Kim,Christopher S. Hourigan,Robert P. Hasserjian,Stephanie Halene, Elizabeth A. Griffiths,Steven D. Gore,Peter Greenberg, Maria E. Figueroa,Pierre Fenaux,Fabio Efficace, Amy E. Dezern,Naval G. Daver,Jane E. Churpek,Hetty E. Carraway,Rena Buckstein, Andrew M. Brunner,Jacqueline Boultwood,Uma Borate,Rafael Bejar,John M. Bennett, Andrew H. Wei,Valeria Santini, Michael R. Savona,Amer M. Zeidan
BLOOD REVIEWS (2023)
Vera Ademà,Irene Gañán-Gómez, Feyiang Ma,Juan José Rodríguez‐Sevilla,Kelly S. Chien,Hui Yang,Natthakan Thongon,Rashmi Kanagal‐Shamanna,Sanam Loghavi,Guillermo Montalban‐Bravo,Danielle Hammond, Ye Gu, Rusung Tan,Lin Tan,Philip L. Lorenzi,Gheath Alatrash,Karen Clise-Dwyer,Rafael Bejar,Matteo Pellegrini, Guillermo Garcia‐Manero,Simona Colla
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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作者统计
#Papers: 169
#Citation: 9835
H-Index: 36
G-Index: 99
Sociability: 7
Diversity: 0
Activity: 2
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