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The research of David Underhill, PhD, focuses on the molecular mechanisms by which blood phagocytes such as macrophages and dendritic cells recognize microbes and initiate inflammatory responses. We are constantly exposed to microbes, both as infectious organisms and as commensal organisms living normally in, for example, our intestines. A central question in immunology is to understand how inflammatory responses are directed specifically against infectious organisms, and how these responses become tailored to specific microbial infections. The laboratory has a long-standing interest in the role of phagocytosis, the process by which immune cells eat foreign microbes, and how this contributes to inflammation. The group is also interested in how the intestinal microbiome, especially the fungi in the gut, regulate immune responses and contribute to inflammatory diseases of the gut. Underhill and his lab members believe that understanding how macrophages and dendritic cells translate recognition of microbes into inflammatory responses will lead to the design of targeted interventions to clinically manipulate these processes.
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论文共 194 篇作者统计合作学者相似作者
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Ignacio Catalan-Serra,Silje Thorsvik,Vidar Beisvag,Torunn Bruland,David Underhill,Arne Kristian Sandvik,Atle van Beelen Granlund
INFLAMMATORY BOWEL DISEASES (2024)
T.B. Dar, A.T. Nguyen, S. Stevens, J. Viramontes, R. Henson, J.K. Jang, J. Guarnerio,D. Underhill, S.L. Shiao
International journal of radiation oncology, biology, physicsno. 2 (2023): e225-e226
International Journal of Radiation Oncology Biology Physicsno. 2 (2023): S166-S166
International journal of radiation oncology, biology, physicsno. 2S (2023)
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Anthony T. Nguyen, Tahir B. Dar, Jolene Viramontes, Satchel Stevens,Julie K. Jang,Emily Ko, D.J. Lu, Eunna Chung,Samuel C. Zhang,Katelyn M. Atkins,Mitchell Kamrava,Howard M. Sandler,
Cancer Researchno. 7_Supplement (2023): 6409-6409
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Mitchell Kamrava,Julie Jang,Emily Ko,Simon Knott,Tahir B Dar,Stephen L Shiao,Anthony T Nguyen, Jolene Viramontes, Satchel Stevens,Eric M Chung, Samuel Zhang,Katelyn M Atkins,
Journal for ImmunoTherapy of Cancerno. Suppl 1 (2023)
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Yong-Joon Cho,Juan Yang,Seung Yong Shin,Hyo Keun Kim, Piyapat Rintarhat,Minji Park, Muhyeon Sung,Katherine Lagree,David Underhill,Dong-Woo Lee,Chang Hwan Choi,Chul-Su Yang,
biorxiv(2023)
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Science immunologyno. 84 (2023)
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GASTROENTEROLOGYno. 6 (2023): S916-S916
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