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In 1995, when Professor Derek Laver entered the medical research field, there was very little understanding of how calcium release channels (called RyRs) were regulated by calcium and magnesium within each cell of the body. He was the first to identify that calcium in the body can inhibit cardiac RyR type 2 channels and he also characterised a dual mechanism for magnesium inhibition in a part of a heart cell called the cytoplasm.
Professor Laver also discovered that a disruption in magnesium inhibition due to mutations could lead to malignant hyperthermia, a life-threatening condition that affects a patient's ability to regulate their body temperature when receiving certain anaesthetics.
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bioRxiv (Cold Spring Harbor Laboratory)no. 3 (2024): 194-201
Sensors (Basel, Switzerland)no. 6 (2023): 3291-3291
bioRxiv : the preprint server for biology (2023)
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The Journal of general physiologyno. 8 (2023)
Research Square (Research Square) (2021)
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