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Current studies are directed to understand and define the individual contributions of TRPC1 and Orai1 to salivary fluid secretion. We are also interested in identifying the regulation of the water channel, AQP5, during stimulation of the gland and secretion. Our work has led to the identification of TRPV4 as an essential TRP channel that is involved in cellular volume regulation. In addition, other TRPC channels, TRPC3 and TRPC6, could also have important role in regulating other aspects of salivary gland function. These studies are ongoing.
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Cell Calcium (2024): 102842-102842
Scientific Reportsno. 1 (2021): 1-12
bioRxiv (Cold Spring Harbor Laboratory) (2021)
Proceedings of the National Academy of Sciences of the United States of Americano. 28 (2020): 16638-16648
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