基本信息
浏览量:5
职业迁徙
个人简介
In 2006 I showed that the interactions of BRCA1 with components that allow it to catalyze the ligation of ubiquitin are likely to be important in cancer predisposition (HMG 2006). This conclusion remains controversial with mouse experiments demonstrating evidence both for and against the idea. My own mouse model (published 2011, Cancer Cell) demonstrates that the region required for ligase activity is also required for tumour suppression and shows separation of tumour suppression function from treatment response. In 2009 my investigations of post-translation modifications in the DNA damage response led to an understanding that the small modifier, SUMO, regulates the wider DNA damage response and specifically regulates BRCA1 ubiquitin ligase activity (Nature 2009). In 2013 we showed that a eky regulator of chromatin state is the SUMO deconjugating enzyme, SENP7 and that its activity is required to allow the relaxation of DNA required for homologous recombination and DNA repair (EMBO R). These contributions show a strong narrative in my research trajectory that I aim to build on.
研究兴趣
论文共 10 篇作者统计合作学者相似作者
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H. R. Stone,J. R. Morris
Suzanne Eccles,Eric Aboagye,Simak Ali,Annie Anderson,Jo Armes,Fedor Berditchevski,Jeremy Blaydes,Keith Brennan,Nicola Brown,Helen Bryant,Nigel Bundred,Joy Burchell,Anna Campbell, Jason Carrol,Robert Clarke,Charlotte Coles,Gary Cook,Angela Cox,Nicola Curtin,Lodewijk Dekker, Isobel Dos Santos Silva,Stephen Duffy,Doug Easton,Diana Eccles,Dylan Edwards,Joanne Edwards,Gareth Evans,Deborah Fenlon,James Flanagan,Claire Foster,William Gallagher,Montserrat Garcia-Closas,Julia Gee,Andy Gescher,Vicky Goh,Ashley Groves,Amanda Harvey,Michelle Harvie,Bryan Hennessy,Stephen Hiscox,Ingunn Holen,Sacha Howell,Tony Howell,Gill Hubbard, Nick Hulbert,Myra Hunter,Bharat Jasani,Louise Jones,Tim Key,Cliona Kirwan,Anthony Kong,Ian Kunkler,Simon Langdon,Martin Leach,David Mann,John Marshall,Lesley Ann Martin,Stewart Martin, Jenny McDougall,David Miles, Bill Miller,Jo Morris,Sue Moss,Paul Mullan,Rachel Natrajan,James O'Connor,Rosemary O'Connor,Carlo Palmieri,Paul Pharoah,Emad Rakha,Elizabeth Reed,Simon Robinson,Erik Sahai,John Saxton,Peter Schmid, Matt Smalley, Val Speirs,Robert Stein,John Stingl,Charles Streuli,Andrew Tutt,Galina Velikova,Rosemary Walker,Christine Watson,Kaye Williams,Leonie Young,Alastair Thompson
user-5f8411ab4c775e9685ff56d3(2013)
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J Barwell,L Pangon,S Hodgson,A Georgiou,I Kesterton,T Slade, M Taylor,S J Payne,H Brinkman, J Smythe, N J Sebire,E Solomon,Z Docherty,R Camplejohn,T Homfray,J R Morris
作者统计
#Papers: 47
#Citation: 2689
H-Index: 23
G-Index: 39
Sociability: 6
Diversity: 3
Activity: 4
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