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The Orthopaedic Hospital Research Center (OHRC) was formed in 2007 under the direction of John S. Adams, M.D. The aim of the OHRC is to create an interdisciplinary (Departments of Orthopaedic Surgery, Molecular Cell and Developmental Biology, Medicine, Broad Stem Cell Institute, etc.), interschool (medical, dental, engineering, etc.) research effort targeted at understanding and treating the most vexing issues in human musculoskeletal disease. Within this framework, the Adams laboratory is dedicated to an understanding of the molecular motive action of vitamin D as both a hormonal regulator of bone and mineral homeostasis as well as a locally-functioning monokine modulating the innate and adaptive immune response in infectious and autoimmune diseases affecting humans. Specifically, we investigate naturally-occurring experiments of nature in human and subhuman primates and transgenic mouse models of those experiments to better understand the means by which vitamin D and other steroid hormones (e.g. estrogen) control gene expression. On a more clinical-translational level we study the consequences of vitamin D insufficiency on the state of immunoreactivity and bone balance in the human host.
The Orthopaedic Hospital Research Center (OHRC) was formed in 2007 under the direction of John S. Adams, M.D. The aim of the OHRC is to create an interdisciplinary (Departments of Orthopaedic Surgery, Molecular Cell and Developmental Biology, Medicine, Broad Stem Cell Institute, etc.), interschool (medical, dental, engineering, etc.) research effort targeted at understanding and treating the most vexing issues in human musculoskeletal disease. Within this framework, the Adams laboratory is dedicated to an understanding of the molecular motive action of vitamin D as both a hormonal regulator of bone and mineral homeostasis as well as a locally-functioning monokine modulating the innate and adaptive immune response in infectious and autoimmune diseases affecting humans. Specifically, we investigate naturally-occurring experiments of nature in human and subhuman primates and transgenic mouse models of those experiments to better understand the means by which vitamin D and other steroid hormones (e.g. estrogen) control gene expression. On a more clinical-translational level we study the consequences of vitamin D insufficiency on the state of immunoreactivity and bone balance in the human host.
研究兴趣
论文共 279 篇作者统计合作学者相似作者
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Elsevier eBookspp.155-187, (2024)
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Nutrientsno. 6 (2023)
CURRENT OPINION IN MICROBIOLOGY (2023): 102322-102322
Charles W Bishop,Akhtar Ashfaq,Joel Z Melnick, Enrique Vazquez-Escarpanter,Jonathan A Fialkow,Stephen A Strugnell, John Choe,Kamyar Kalantar-Zadeh,Noah C Federman,David Ng,John S Adams
Microbiology spectrumno. 3 (2023)
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Malaria Journalno. 1 (2023): 1-10
Scientific reportsno. 1 (2023): 12998-13
Nutrientsno. 1380 (2023): 1380
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Genome biologyno. 1 (2023): 231-231
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