The Eidsmo Laboratory explores mechanisms that steer health and immunopathology in human skin. In healthy skin, the Eidsmo Laboratory has defined functionally distinct subsets of tissue resident memory T (Trm) cells based on their expression of the integrin CD49a. In diseases such as vitiligo and psoriasis, we have shown the involvement of different subsets of pathogenic Trm cells in the formation of localized disease memories in resolved skin.