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Professor Moffatt has worked for 24 years in the field of genetics focusing on the allergic diseases, asthma and atopic dermatitis with her research partner Professor Cookson and their team. Together they have investigated the genetic mechanisms underlying asthma using candidate gene and positional cloning approaches and most recently genome wide association studies (GWAS). Their landmark GWAS study of 1,000 cases of childhood asthma and 1,000 controls identified the ORMDL3 locus on chromosome 17q21, which is now recognised to be the strongest and most consistent genetic association to childhood asthma. Because of the importance of mucosal immunity in asthma, Professors Moffatt and Cookson have initiated studies characterizing the airway microbiome of the normal healthy lung as well as that seen in a variety of key respiratory diseases including asthma, chronic obstructive pulmonary disease, bronchiectasis and cystic fibrosis.
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JOURNAL OF CLINICAL ONCOLOGYno. 16 (2023)
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Epidemiology (2011)
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