Pascal E Sanchez - Denali Therapeutics, Inc.

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论文共 48 篇作者统计合作学者相似作者

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DNL343 is an Investigational CNS Penetrant Eif2b Activator That Prevents and Reverses the Effects of Neurodegeneration Caused by the Integrated Stress Response

Ernie Yulyaningsih,Jung H. Suh, Melania H. Fanok,Roni Chau,Hilda Solanoy,Ryan Takahashi,Anna I. Bakardjiev,Isabel Becerra, N. Butch Benitez,Chi-Lu Chiu,Sonnet S Davis,William E. Dowdle,Timothy Earr,Anthony A. Estrada,Audrey Gill,Connie Ha,Patrick C. G. Haddick,Kirk R. Henne,Martin Larhammar,Amy Wing-Sze Leung,Romeo Maciuca, Bahram Memarzadeh,Hoang N. Nguyen,Alicia Nugent,Maksim Osipov, Yingqing Ran, Kevin Rebadulla,Elysia Roche,Thomas Sandmann,Jing Wang,Joseph W. Lewcock,Kimberly Scearce-Levie,Lesley A. Kane,Pascal E. Sanchez

biorxiv（2024）

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Targeting the Transferrin Receptor to Transport Antisense Oligonucleotides Across the Mammalian Blood-Brain Barrier

Scarlett J. Barker, Mai B. Thayer, Chaeyoung Kim, David Tatarakis,Matthew J. Simon, Rebekah Dial, Lizanne Nilewski, Robert C. Wells, Yinhan Zhou,Megan Afetian,Padma Akkapeddi,Alfred Chappell,Kylie S. Chew, Johann Chow, Allisa Clemens, Claire B. Discenza,Jason C. Dugas,Chrissa Dwyer,Timothy Earr,Connie Ha, Yvonne S. Ho,David Huynh, Edwin I. Lozano, Srini Jayaraman,Wanda Kwan,Cathal Mahon,Michelle Pizzo,Yaneth Robles-Colmenares, Elysia Roche, Laura Sanders, Alexander Stergioulis,Raymond Tong,Hai Tran, Joy Yu Zuchero,Anthony A. Estrada, Kapil Gadkar, Christopher M. M. Koth,Pascal E. Sanchez,Robert G. Thorne, Ryan J. Watts,Thomas Sandmann,Lesley A. Kane, Frank Rigo,Mark S. Dennis,Joseph W. Lewcock,Sarah L. Devos

SCIENCE TRANSLATIONAL MEDICINEno. 760 (2024)

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Engineering anti-amyloid antibodies with transferrin receptor targeting improves safety and brain biodistribution

Michelle E Pizzo, Edward D Plowey, Nathalie Khoury,Wanda Kwan, Jordan Abettan,Sarah L DeVos, Claire B Discenza,Timothy Earr, David Joy, Ming Lye-Barthel, Elysia Roche,Darren Chan,Jason C Dugas, Kapil Gadkar, René Meisner, Jennifer Sebalusky, Ana Claudia Silva Amaral, Isabel Becerra,Roni Chau, Johann Chow, Allisa J Clemens,Mark S Dennis,Joseph Duque, Laura Fusaro,Jennifer A Getz,Mihalis S Kariolis, Do Jin Kim,Amy Wing-Sze Leung,Hoang N Nguyen,Elliot R Thomsen,Pascal E Sanchez, Lu Shan,Adam P Silverman,Hilda Solanoy,Raymond Tong,Meredith E K Calvert, Ryan J Watts,Robert G Thorne, Paul H Weinreb, Dominic M Walsh,Joseph W Lewcock, Thierry Bussiere,Y. Joy Yu Zuchero

biorxiv（2024）

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Rescue of a Lysosomal Storage Disorder Caused by Grn Loss of Function with a Brain Penetrant Progranulin Biologic

Todd Logan,Matthew J. Simon,Anil Rana,Gerald M. Cherf,Ankita Srivastava,Sonnet S. Davis,Ray Lieh Yoon Low,Chi-Lu Chiu,Meng Fang,Fen Huang,Akhil Bhalla,Ceyda Llapashtica,Rachel Prorok,Michelle E. Pizzo,Meredith E. K. Calvert,Elizabeth W. Sun,Jennifer Hsiao-Nakamoto,Yashas Rajendra,Katrina W. Lexa,Devendra B. Srivastava,Bettina van Lengerich,Junhua Wang,Yaneth Robles-Colmenares,Do Jin Kim,Joseph Duque,Melina Lenser,Timothy K. Earr,Hoang Nguyen,Roni Chau,Buyankhishig Tsogtbaatar,Ritesh Ravi,Lukas L. Skuja,Hilda Solanoy,Howard J. Rosen,Bradley F. Boeve,Adam L. Boxer,Hilary W. Heuer,Mark S. Dennis,Mihalis S. Kariolis,Kathryn M. Monroe,Laralynne Przybyla,Pascal E. Sanchez,Rene Meisner,Dolores Diaz,Kirk R. Henne, Ryan J. Watts,Anastasia G. Henry,Kannan Gunasekaran,Giuseppe Astarita,Jung H. Suh,Joseph W. Lewcock,Sarah L. DeVos,Gilbert Di Paolo

Cell（2024）

引用101浏览0WOS引用

101

ETV:SGSH, a Brain-Penetrant Enzyme Transport Vehicle for SGSH, Improves Lysosomal and Microglial Morphology, Degeneration and Cognitive Behavior in MPS IIIA Mice

Shababa T. Masoud,Hoang Nguyen,Claire Discenza,David Joy,Jeffrey Simms,Iris Lo, You Young Chun,Julia Holtzman, Khishig Tsogtbaatar,Amy Wing-Sze Leung,Isabel Becerra,Elliot Thomsen,Audrey Gill,Yashas Rajendra,Alexander Seay,Mohammad Jafarnejad,Anna Bakardjiev,Meredith E. K. Calvert,Cathal S. Mahon,Robert Thorne, Steven Chessler,Kirk Henne,Pascal Sanchez,Annie Arguello

MOLECULAR GENETICS AND METABOLISMno. 2 (2024)

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DNL343 is an Investigational CNS Penetrant Eukaryotic Initiation Factor 2B Activator That Prevents and Reverses the Effects of Neurodegeneration Caused by the Integrated Stress Response

Ernie Yulyaningsih,Jung H Suh, Melania Fanok,Roni Chau,Hilda Solanoy, Ryan Takahashi,Anna I Bakardjiev, Isabel Becerra, N Butch Benitez,Chi-Lu Chiu, Sonnet S Davis,William E Dowdle,Timothy Earr,Anthony A Estrada,Audrey Gill,Connie Ha, Patrick C G Haddick,Kirk R Henne,Martin Larhammar,Amy W-S Leung,Romeo Maciuca, Bahram Memarzadeh,Hoang N Nguyen,Alicia A Nugent, Maksim Osipov, Yingqing Ran, Kevin Rebadulla, Elysia Roche, Thomas Sandman, Jing Wang,Joseph W Lewcock, Kimberly Scearce-Levie,Lesley A Kane,Pascal E Sanchez

eLife (2024)

引用0浏览0WOS引用

Targeting Transferrin Receptor to Transport Antisense Oligonucleotides Across the Blood-Brain Barrier

Scarlett J Barker,Mai B Thayer,Chaeyoung Kim,David Tatarakis,Matthew Simon, Rebekah L Dial, Lizanne Nilewski,Robert C Wells,Yinhan Zhou,Megan Afetian,Alfred Chappell,Kylie S Chew,Johann Chow, Allisa Clemens, Claire B Discenza,Jason Dugas,Chrissa Dwyer,Timothy Earr,Connie Ha,David Huynh, Srini Jayaraman,Wanda Kwan,Cathal Mahon,Michelle Pizzo,Elysia Roche, Laura Sanders, Alexander Stergioulis,Raymond Tong,Hai Tran,Joy Zuchero,Anthony A Estrada,Kapil Gadkar, Christopher MM Koth,Pascal E Sanchez,Robert G Thorne,Ryan J Watts,Thomas Sandmann,Lesley Kane,Frank Rigo, Mark S Dennis,Joseph W Lewcock,Sarah L DeVos

bioRxiv (Cold Spring Harbor Laboratory) (2023)

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A TREM2‐activating Antibody with a Blood–brain Barrier Transport Vehicle Enhances Microglia Function

Pascal E. Sanchez

Alzheimer's &amp Dementiano. S21 (2023)

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A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models

Bettina van Lengerich,Lihong Zhan,Dan Xia,Darren Chan,David Joy,Joshua I. Park,David Tatarakis,Meredith Calvert,Selina Hummel,Steve Lianoglou,Michelle E. Pizzo,Rachel Prorok,Elliot Thomsen,Laura M. Bartos,Philipp Beumers,Anja Capell,Sonnet S. Davis, Lis de Weerd,Jason C. Dugas,Joseph Duque,Timothy Earr,Kapil Gadkar,Tina Giese,Audrey Gill,Johannes Gnörich,Connie Ha,Malavika Kannuswamy,Do Jin Kim,Sebastian T. Kunte,Lea H. Kunze,Diana Lac,Kendra Lechtenberg,Amy Wing-Sze Leung,Chun-Chi Liang,Isabel Lopez,Paul McQuade, Anuja Modi, Vanessa O. Torres,Hoang N. Nguyen, Ida Pesämaa,Nicholas Propson,Marvin Reich,Yaneth Robles-Colmenares,Kai Schlepckow,Luna Slemann,Hilda Solanoy,Jung H. Suh,Robert G. Thorne, Chandler Vieira,Karin Wind-Mark, Ken Xiong,Y. Joy Yu Zuchero,Dolo Diaz, Mark S. Dennis,Fen Huang,Kimberly Scearce-Levie,Ryan J. Watts,Christian Haass,Joseph W. Lewcock,Gilbert Di Paolo,Matthias Brendel,Pascal E. Sanchez, Kathryn M. Monroe

Nat Neurosci（2023）

引用21浏览0WOSNATURE引用

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