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职业迁徙
个人简介
Our aims are to utilise molecular biology to establish new technologies to study and understand cancer. We are trying to define how chromosomal translocation genes affect proliferation and differentiation from cancer initiating cells (where translocations occur) to overt cancer and in epithelial cancers, to invasive disease. This work amalgamates technologies for creating in vivo models of chromosomal translocations that mark the cancer initiating cells with fluorescent protein expression and transcriptome analysis (concentrating on the surfaceome and transcription factor expression patterns) using deep sequencing RNA-seq to discover new potential therapy targets.
The second, allied aim of our work, involves establishing technologies to target protein function inside cells particularly protein-protein interactions, using antibody fragments as drug surrogates for functional ablation of target proteins (our intracellular immunotherapy programme). We are isolating small molecules and peptides that mirror the inhibitory properties of the antibody fragments and our goals are to develop laboratory reagents to study cancer development and drug-like molecules as leads for therapeutic application. Allied to these approaches, we are examining cell surface protein expression in primary tumours and metastatic disease to define cell interactions that potentiate cancer and identify molecules at the cell surface that could be used in therapy, such as conventional antibody-mediated cancer treatment.
The second, allied aim of our work, involves establishing technologies to target protein function inside cells particularly protein-protein interactions, using antibody fragments as drug surrogates for functional ablation of target proteins (our intracellular immunotherapy programme). We are isolating small molecules and peptides that mirror the inhibitory properties of the antibody fragments and our goals are to develop laboratory reagents to study cancer development and drug-like molecules as leads for therapeutic application. Allied to these approaches, we are examining cell surface protein expression in primary tumours and metastatic disease to define cell interactions that potentiate cancer and identify molecules at the cell surface that could be used in therapy, such as conventional antibody-mediated cancer treatment.
研究兴趣
论文共 356 篇作者统计合作学者相似作者
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Antibodiesno. 1 (2023): 24
Cristiana Barone,Roberto Orsenigo,Anna Cazzola,Elisabetta D'Errico,Arianna Patelli,Giulia Quattrini,Barbara Vergani,Silvia Bombelli,Sofia De Marco,Cristina D'Orlando,Cristina Bianchi,Biagio Eugenio Leone,Raffaella Meneveri,Andrea Biondi,Giovanni Cazzaniga,Terence Howard Rabbitts,Silvia Brunelli,Emanuele Azzoni
Cancersno. 14 (2023): 3624-3624
crossref(2023)
Shaheen S. Sikandar,Gunsagar S. Gulati,Jane Antony,Isobel Fetter,Angera H. Kuo,William Hai Dang Ho,Veronica Haro-Acosta,Soumyashree Das,Chloe B. Steen,Thiago Almeida Pereira,Dalong Qian,Philip A. Beachy,Fredrick Dirbas,Kristy Red-Horse,Terence H. Rabbitts,Jean Paul Thiery,Aaron M. Newman,Michael F. Clarke
Science advancesno. 45 (2022)
eLife (2021)
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作者统计
#Papers: 359
#Citation: 31119
H-Index: 94
G-Index: 170
Sociability: 7
Diversity: 4
Activity: 19
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