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Over the past twenty-five years he and Miriam Moffatt have developed a successful research group devoted to understanding the genetic causes of asthma.
Many of the genes identified by these studies are concentrated in the airway epithelium, so that asthma is now recognised as a disease of the airway mucosa. Genes identified by the group such as ORMDL3, IL33, TSLP and IL18R1 are the focus for new asthma therapies.
In addition to detailed investigation of the functions of these major asthma genes, the group are also systematically charting inflammatory pathways by gene expression, RNA sequencing, and gene knockdowns in cellular models of inflammation. These studies are the basis for developing new therapies for asthma and mucosal inflammation (genomic pharmacology).
The group have pioneered gene expression mapping to identify the function of loci identified by genome-wide association studies. The resulting comprehensive maps of expression quantitative trait loci (eQTLs) (Dixon A. et al., Nature Genetics 2007, Liang L. et al, Genome Resarch 2013) have aided the systematic detection of genes underlying many complex disorders and have contributed to the 1000 genomes project.
The group are currently concentrating their mapping efforts on the epigenome, by measuring changes in the methylation of particular regions of the genome that regulate gene expression. Their early results suggest that this will be a rich source of new biological insights into asthma and allergic diseases.
Many of the genes identified by these studies are concentrated in the airway epithelium, so that asthma is now recognised as a disease of the airway mucosa. Genes identified by the group such as ORMDL3, IL33, TSLP and IL18R1 are the focus for new asthma therapies.
In addition to detailed investigation of the functions of these major asthma genes, the group are also systematically charting inflammatory pathways by gene expression, RNA sequencing, and gene knockdowns in cellular models of inflammation. These studies are the basis for developing new therapies for asthma and mucosal inflammation (genomic pharmacology).
The group have pioneered gene expression mapping to identify the function of loci identified by genome-wide association studies. The resulting comprehensive maps of expression quantitative trait loci (eQTLs) (Dixon A. et al., Nature Genetics 2007, Liang L. et al, Genome Resarch 2013) have aided the systematic detection of genes underlying many complex disorders and have contributed to the 1000 genomes project.
The group are currently concentrating their mapping efforts on the epigenome, by measuring changes in the methylation of particular regions of the genome that regulate gene expression. Their early results suggest that this will be a rich source of new biological insights into asthma and allergic diseases.
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论文共 14 篇作者统计合作学者相似作者
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medRxivno. 4 (2023): 798-799
biorxiv(2022)
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