Bhima Bhoi Medical College and Hospital, Balangir is a full-fledged tertiary Government medical college in Balangir, Odisha. The college imparts the degree Bachelor of Medicine and Bachelor of Surgery (MBBS). It is recognized by the National Medical Commission The hospital associated with the college is one of the largest in the Balangir district.Selection to the college is done on the basis of merit through the National Eligibility and Entrance Test. Yearly undergraduate student intake is 100.
Introduction: Dyslipidaemia is a major risk factor for Cardio-metabolic disease and its complications which is showing an increasing trends in adults worldwide. Lipid imbalance detection during adolescent period can forecast the development of cardio-metabolic disease in adulthood. The Primary Objective of the study was to assess the lipid profile parameters in the school going urban adolescents of the age group of 10-19 years. Secondary Objectives: To find out the prevalence of metabolic syndrome among the study population using NCEP-III criteria. Methods: It was an observational analytical cross-sectional study conducted for a period of two years in the school going urban adolescents of the age group of 10-19 years. Sample size was 679. Results: Out of 679 study population female were 554 (81.6% ) and 125(18.4% ) males. The mean age among male & female respondents were 13.8±0.9 & 14.7±1.8 years respectively. Majority of the respondents from both the gender belongs to the age group of 14-16 years [Male- 81( 64.8%), Female-366(66.1%)]. The overall results revealed that prevalence of dyslipidaemia & Metabolic syndrome was found to be 496 (73%) & 47(6.9%). Majority of the participants had low HDL Value { females- 400(72.2%) , Males- 96(76.8%). High triglyceride level was seen in {Female- 119(21.5%) ,Male- 18(14.4%)}. Borderline & high LDL value was observed in seven(1.3%) females only. Borderline cholesterol levels were seen in [Female- 21 (3.8%) and male- 2(1.6%)]. Seven(1.6%) female participants had very high cholesterol level. Total of 72(10.6%) adolescents had blood pressure ≥130/85mm of HG. Conclusion: Early risk assessment should begin in adolescence in order to design and implement lifestyle or pharmacological interventions that might be effective in preventing the mortality & morbidity caused by Cardiometabolic disease in adulthood. Keywords: Atherosclerosis, CVD, Dyslipidaemia , lipid markers, NCEP-III guidelines.
A BSTRACT Introduction: Many surgical and medical treatments are available for chronic anal fissure, with their merits, demerits, and different outcomes. Wounds can heal primarily or secondarily. The principle of treatment is resurfacing of the wound with a skin graft or flap. Skin grafting results in primary healing and early epithelization, which will reduce scar formation and complications. The same principle may be applied in chronic anal fissure to accelerate healing and prevent complications. Objective: The objective is to find out the outcomes of fissurectomy and full-thickness skin graft in patients with chronic fissure in ano and compare it with the fissurectomy method. Methods: The study was time-bound, prospective, comparative, and nonrandomized. Eighty patients were segregated into Group A (fissurectomy and full-thickness skin graft) and Group B (fissurectomy). Data were collected and analyzed in SPSS 2.0 version software. Results: Average days of hospital stay and time taken to heal were less in Group A than in Group B. The maximum number of patients got relieved from chronic pain (92.5%) and bleeding per anum (95%) in Group A, and the percentage of recurrence of disease is 5% in Group A and 35% in Group B study. Conclusion: Healing is faster, recurrence is very low, and the maximum number of patients were relieved from pain and bleeding per anum in Group A study. Probable recurrence in Group A is due to poor graft take-up. Fissurectomy with a full-thickness skin graft is a new concept, and this method may be adopted for the surgical treatment of chronic anal fissure for faster healing and to prevent complications.
Objectives: In this cross-sectional study, the aims were to analyze the incidence and pattern of adverse drug reactions (ADRs) of antiepileptic drugs in pediatric patient. Most common adverse effect and most common drug causing adverse effect were evaluated.Methods: Study was conducted over 60 Patients for 6 months in out-patient basis pediatric department in Rajindra Hospital associated with GMC, Patiala, a tertiary care teaching hospital in Punjab. The patient diagnosed by the Pediatrician with epilepsy who fulfilling inclusion and exclusion criteria was enrolled after taking informed consent. ADRs were noted using Pediatric Epilepsy Side Effect Questionnaire at clinic visit and any other adverse effects reported by patients.Results: In this study, a total of 60 children were enrolled. The mean age was 10.26±3.70, median were 11.00. 41 (68.33%) patients were boys and 19 (31.67%) were girls. In Cognitive ADRs with anti-epileptic drugs, there were total 17 ADRs reported. Valproate was causing most cognitive ADRs (32.43%). Among all cognitive ADRs, attention difficulty was the commonest complains. There were no motor and behavioral ADRs reported. Total 27 general neurological ADRs reported, which was highest reported ADRs. Among general neurological, Clobazam was causing highest ADRs (55.56%). 10 patients also reported tremor as another ADR and Clobazam causing most (22.22%).Conclusion: In the present study, boys were developing more epilepsy than girls. Valproate was causing most ADRs. Among all cognitive ADRs, attention difficulty was the most common ADR. General neurological ADRs were highest reported ADRs.
Background: Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory disorder marked by intense yet ineffective immune activation, resulting in hemophagocytosis, systemic inflammation, and multi-organ dysfunction. The diagnosis has traditionally depended on the 2004 HLH criteria, while the HScore, introduced in 2014, presents an alternative diagnostic approach. Materials and Methods: A 2-year study was conducted on patients referred to the hematology division for bone marrow evaluation. Patients with fever, cytopenia, and organomegaly underwent comprehensive biochemical and hematological assessments, including bone marrow aspiration. HLH diagnosis was established using both the HScore and the 2004 HLH criteria. Results: Among 48 patients with fever, organomegaly, and cytopenia, 16 (33%) met the HLH diagnostic threshold with an HScore above 169, and 12 cases (75%) showed evidence of hemophagocytosis in the bone marrow. Based on the 2004 HLH criteria, 11 cases (29%) met the diagnostic requirements, achieving scores above five out of eight parameters. Conclusion: A timely and accurate diagnosis of HLH is crucial, as delays can lead to worse outcomes. Employing the 2004 criteria and the HScore is an effective diagnostic strategy, with the HScore showing higher accuracy.
