Nanozymes with intrinsic ROS-generating abilities hold promise as next-generation antimicrobials; however, optimizing their enzyme-mimic efficiency remains a significant challenge. Here, we fabricated popcorn-shaped copper-erbium nanoalloys (CuEr NAs) via a simple one-pot coreduction method, resulting in stabilized nanoconstructs with dual enzyme-mimic activities. We described that CuEr NAs effectively inactivate Escherichia coli (E. coli) by generating intracellular ROS and depleting glutathione (GSH) through the release of copper ions. These ions induced oxidative stress by generating hydroxyl radicals (center dot OH) in acidic environments and oxidizing GSH to glutathione disulfide (GSSG), thereby amplifying ROS generation. CuEr NAs exhibited potent antibacterial activity and enhanced wound healing efficacy in an infected wound model by reducing the bacterial load, ameliorating inflammation, and promoting tissue remodeling. Histological analysis showed enhanced collagen deposition and re-epithelialization in wounds treated with CuEr NAs, highlighting their potential as a flexible platform for antimicrobial and regenerative biomedical applications. This study highlights CuEr NAs as a viable platform for antimicrobial applications and provides insights into the fabrication of multifunctional nanoantimicrobials.
The human intelligent perceptional system employs two fundamental modules-sensing and computing-to engage with the external environment. The von Neumann architectures, however, inherently face the memory-wall and power-wall challenges. In response to these issues, neuromorphic computing has emerged as a potential paradigm, minimizing data migration via in-memory computing frameworks and eliminating analog-to-digital conversion through near-sensor processing. Despite this, conventional methods of power supply and data transmission constrain the application of this nanoscale neuromorphic architecture in edge computing. This article presents a battery-free neuromorphic computing approach that integrates memristor-based neuromorphic computing with near-field communication (NFC) transponder chip-assisted power supply and wireless communication. The performance of this system is evaluated based on its ability to classify distinct optical characters. The battery-free power supply ensures energy consumption only during the execution of the classification task, while neuromorphic computing reduces the volume of data to be transferred. Our demonstration offers a promising avenue for the application of neuromorphic computing, particularly in the field of edge computing.
Contact-electro-catalysis (CEC) is an emerging approach for promoting chemical reactions, with conventional dielectric powders being the most commonly used CEC catalysts. However, the dielectric powders are usually difficult to recycle, and the membrane counterparts suffer from low efficiency. Here, we devised a plate polarization strategy to enhance the contact electrification (CE) ability and, thus, the CEC efficiency of dielectric films. Exemplified by fluorinated ethylene propylene films, the density of fluorine groups on the surface could increase due to electrostatic polarizations, which is beneficial for the subsequent production of reactive oxygen species through CEC. A 5 ppm methyl orange aqueous solution could be completely degraded after ultrasonication for 300 min. We expect that this study could pave the way for the practical application of film-based CEC, offering a sustainable and cost-effective solution for environmental pollution control.
ObjectiveWe conducted an integrative review to identify family support categories that have been described as components of early childhood home visiting models in empirical research and to distinguish whether supports were formal or informal.BackgroundKey components of most early childhood home visiting models include family supports intended to promote child and family outcomes. Categories of family support have been described in other extant literature: (a) material, (b) informational, (c) social-emotional, and (d) organizational. Family support has been further categorized as formal or informal. In this literature, informal supports have been characterized as more enduring and meaningful than formal ones.MethodA systematic literature search was conducted. A total of 244 studies representing 127 early childhood home visiting models were located and coded.ResultsFormal informational supports were the most frequently reported family support category. Informal supports were reported much less frequently than formal supports.ConclusionGiven the enduring impacts of informal family supports, home visiting models should include both informal and formal supports. Empirical studies should include descriptions of the types of family supports in home visiting models and more explicitly hypothesize linkages to intended outcomes.ImplicationsFuture work should include refining the definitions of support categories, distinguishing informal and formal supports, exploring interactions among supports, and understanding the functions of supports from the perspectives of families and home visitors.
