Dhruba Chand Halder College

The genetic blueprint of life faces ongoing threats from physical and chemical agents that can disrupt DNA and lead to genomic instability, which is one of the hallmarks of cancer. These agents include external factors like ionizing radiation, UV radiation, radiotherapy, and chemotherapeutic drugs or internal factors like redox imbalance arising from deregulated cellular metabolism. These agents damage DNA by generating inter-strand crosslinks, DNA-protein crosslinks, bulky adducts or double-strand breaks that ultimately decreases genomic integrity and leads to tumorigenesis. The coordinated actions of E3 ubiquitin ligases and deubiquitinases (DUBs) are essential in the precise control of these DNA damage tolerance and repair pathways. This has unravelled vulnerable points for intervention in cancer chemoresistance, since it has been observed that these ubiquitinases and deubiquitinases may upregulate repair proteins that reverses DNA damage conferred by conventional chemotherapeutics. This review focusses on the intricate dynamics of ubiquitination and deubiquitination in controlling DNA damage repair pathways and safeguarding genomic integrity.

Analysis of Financial performance that can evaluates the financial health of companies. The study presents a systematic literature review to assess past research focused on the use of solvency, liquidity and profitability indicators for financial analysis. In this paper, it has been analysed how macroeconomic factors affect solvency. It has also been observed that interest rates and inflation influence debt levels and capital structure across industries. The findings show that traditional liquidity ratios lack of debt. In the other hand cash flow analysis offers better insights. There is limited use of ESG in profitability analysis, though firms with good governance show better earnings and firms with sustainable practices often perform better in the long run. The dominance of Altman Z score is also observed with limited focus on distress indicators. The study will help stakeholders make better decisions and promote more sustainable financial practices in a growing economy.

The art of management is as old as human civilization. The prosperity of any civilization is positively correlated with the quality of its management. The success and glory of ancient India proves that the Indians had mastered the art of management much before the formal theorization of the disciplineby the West. The Indian classics like the Vedas, the Puranas, the Upanishads, and the Bhagavad Gita have been studied by people since ancient times to appreciate their spiritual, religious or moral values. The author firmly believes that they also contain timeless management wisdom which has rarely been deciphered. The present study aims to analyze the first chapter of the Bhagavad Gita, coinedas Arjuna’s Vishada Yoga, to understand the management operations of that era from the perspectives of modern managers. It is found that the invincible wisdom of that period had much insight which can enrich today’s managers. The knowledge might inspire modern managers to focus on issues which may help them to control their binary minds and to excel in their chosen fields of devotion.

In the age of soft skills and dominant service sectors in urban areas, equal opportunity has become the buzzword and is practiced across industries. Gender equality is promoted not only by the institutions or society but also ensured through legislations. The study focuses on the causes of gender discrimination at the workplace analysed from a representative sample of 500 employees (250 male and 250 female employees) drawn from 50 corporate houses in and around Kolkata. The data is collected from the responses received through an empirical study with a close ended questionnaire. On performance of Rotated Component Matrix of the variables, 5 factors are found which are coined as Workplace Dynamics, Work-Life Balance, Workplace Flexibility, Job Satisfaction, and Professional Networking. Through Independent-Samples Kruskal-Wallis H Test, it is found that there are no significant differences among genders with respect to Workplace Dynamics and Job Satisfaction. This shows that variables relating to workplace legislations, working conditions, pay, promotion and appraisal are adequately addressed in the sample organisations. However, significant difference is observed among genders with respect to Work-Life Balance, Workplace Flexibility, and Professional Networking with the male employees displaying more positive results than females. This shows that variables like flexible working hours, favourable transfer, balancing domestic responsibilities, provisions for child care, adequate grievance handling cell, etc. are not adequately addressed. These results also prove that although modern institutions have come a long way to ensure gender equality, bias prevails and a lot needs to be addressed to.

Kalyani Thakur Charal writes from a Dalit feminist perspective. Dalit women are subjected to triple marginalities marginalities owing to class, caste, and gender. The violence, oppression, and discrimination faced by them can be effectively analyzed using an intersectional framework as their subjectivities are constituted by mutually reinforcing vectors of class, caste, and sexuality. Kalyani Thakur Charal is acutely aware of the challenges and obstacles faced by Dalit women in Bengal. Her writing articulates not only her story but also that of the men and women of her community. Dalit voices are silenced in myriad ways. The silencing of Dalit realities is an act of violence that she resists. She uses her pen to protest against the overt and covert use of violence against Dalits. She points out how “Dalit sympathizers rise to exploit the Dalits.” She resists marginalization and silencing by foregrounding her identity as ‘charal.’ She embraces her ‘charal’ (chandal) identity and uses it as a weapon to resist violence, marginalization, and humiliation. She has created a space of her own, forcing the world at large to hear and recognize her worth. Apart from her poems and prose writings, she also edits a vernacular journal titled Nir (Nest), which deals with Dalit issues. She uses literature as a site of resistance and healing. The paper situates her work in the context of Dalit women poets of Bengal and focuses on her selected poems to depict how Kalyani Thakur Charal negotiates the complexities associated with the Dalit feminist standpoint.