Dhruba Chand Halder College

The genetic blueprint of life faces ongoing threats from physical and chemical agents that can disrupt DNA and lead to genomic instability, which is one of the hallmarks of cancer. These agents include external factors like ionizing radiation, UV radiation, radiotherapy, and chemotherapeutic drugs or internal factors like redox imbalance arising from deregulated cellular metabolism. These agents damage DNA by generating inter-strand crosslinks, DNA-protein crosslinks, bulky adducts or double-strand breaks that ultimately decreases genomic integrity and leads to tumorigenesis. The coordinated actions of E3 ubiquitin ligases and deubiquitinases (DUBs) are essential in the precise control of these DNA damage tolerance and repair pathways. This has unravelled vulnerable points for intervention in cancer chemoresistance, since it has been observed that these ubiquitinases and deubiquitinases may upregulate repair proteins that reverses DNA damage conferred by conventional chemotherapeutics. This review focusses on the intricate dynamics of ubiquitination and deubiquitination in controlling DNA damage repair pathways and safeguarding genomic integrity.

Analysis of Financial performance that can evaluates the financial health of companies. The study presents a systematic literature review to assess past research focused on the use of solvency, liquidity and profitability indicators for financial analysis. In this paper, it has been analysed how macroeconomic factors affect solvency. It has also been observed that interest rates and inflation influence debt levels and capital structure across industries. The findings show that traditional liquidity ratios lack of debt. In the other hand cash flow analysis offers better insights. There is limited use of ESG in profitability analysis, though firms with good governance show better earnings and firms with sustainable practices often perform better in the long run. The dominance of Altman Z score is also observed with limited focus on distress indicators. The study will help stakeholders make better decisions and promote more sustainable financial practices in a growing economy.

Durga Puja celebrated by the Bonedi families of Kolkata represents a major segment of Bengal’s intangible cultural heritage, which testifies to the socio-cultural, economic, and historical transformation of the city from the colonial period onwards. Although Durga Puja has received global recognition as a UNESCO Intangible Cultural Heritage of Humanity, the historical narratives, family traditions, ritual practices, and associated memories of many centuries-old Bonedi household, pujas remain inadequately documented and dispersed across different information sources. The present study investigates the scenario of local history collection related to Durga Puja in Bonedi families of the Kolkata Municipal Corporation area, present in century-old public libraries, family archives, social media platforms, and collective memory. The findings reveal that information related to Bonedi Bari Durga Puja exists within a fragmented documentary ecosystem. While private family archives and social media platforms preserve valuable historical narratives, century-old public libraries often lack systematic local history collections, specialized services, trained manpower, and collection development strategies focusing on immediate cultural heritage. The study recommends an integrated heritage information management framework involving public libraries, family archives, academic institutions, museums, and digital platforms.

The art of management is as old as human civilization. The prosperity of any civilization is positively correlated with the quality of its management. The success and glory of ancient India proves that the Indians had mastered the art of management much before the formal theorization of the disciplineby the West. The Indian classics like the Vedas, the Puranas, the Upanishads, and the Bhagavad Gita have been studied by people since ancient times to appreciate their spiritual, religious or moral values. The author firmly believes that they also contain timeless management wisdom which has rarely been deciphered. The present study aims to analyze the first chapter of the Bhagavad Gita, coinedas Arjuna’s Vishada Yoga, to understand the management operations of that era from the perspectives of modern managers. It is found that the invincible wisdom of that period had much insight which can enrich today’s managers. The knowledge might inspire modern managers to focus on issues which may help them to control their binary minds and to excel in their chosen fields of devotion.

In the age of soft skills and dominant service sectors in urban areas, equal opportunity has become the buzzword and is practiced across industries. Gender equality is promoted not only by the institutions or society but also ensured through legislations. The study focuses on the causes of gender discrimination at the workplace analysed from a representative sample of 500 employees (250 male and 250 female employees) drawn from 50 corporate houses in and around Kolkata. The data is collected from the responses received through an empirical study with a close ended questionnaire. On performance of Rotated Component Matrix of the variables, 5 factors are found which are coined as Workplace Dynamics, Work-Life Balance, Workplace Flexibility, Job Satisfaction, and Professional Networking. Through Independent-Samples Kruskal-Wallis H Test, it is found that there are no significant differences among genders with respect to Workplace Dynamics and Job Satisfaction. This shows that variables relating to workplace legislations, working conditions, pay, promotion and appraisal are adequately addressed in the sample organisations. However, significant difference is observed among genders with respect to Work-Life Balance, Workplace Flexibility, and Professional Networking with the male employees displaying more positive results than females. This shows that variables like flexible working hours, favourable transfer, balancing domestic responsibilities, provisions for child care, adequate grievance handling cell, etc. are not adequately addressed. These results also prove that although modern institutions have come a long way to ensure gender equality, bias prevails and a lot needs to be addressed to.