Dow Medical College is a public medical school located in the city of Karachi, Sindh. It was founded in 1945 and named after British civil servant Sir Hugh Dow, Governor of Sindh.In 2003, it became a constituent college of the newly formed Dow University of Health Sciences.
Both lung cancer and diabetes are the leading causes of death worldwide. These two conditions commonly coexist, especially in older patients, and result in worsening of prognosis and lower survival rates. Very limited scientific data are available about their correlation. Studying the mortality trends using data from Centers for Disease Control and Prevention Wide-Ranging Online Data of Epidemiologic Research (CDC WONDER) can help us in designing better health policies and treatment strategies. We analyzed the US mortality data from 1999 to 2023 using the CDC WONDER dataset. The ICD-10 codes were used. For lung cancer, it is C34, and for diabetes, they are E10-14. Temporal trends were analyzed by using joinpoint regression (V5.4.0) and a p value < 0.05 was considered statistically significant. From 1999 to 2023, a total of 174,418 deaths were reported in the United States. Most of them occurred at home (39.6
Background:Hypertension and diabetes are among the most prevalent conditions in the world, which can severely affect the kidneys, especially when they occur together. This study analyzes mortality trends among the American population with hypertensive kidney disease (HKD) and diabetes. Methods:We carried out a retrospective analysis from 1999 to 2024 of nationwide mortality data obtained from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) database. We included individuals with HKD diabetes (ICD-10 codes: I12, E10-E14) using a multiple cause of death approach (reporting any mention of the diagnosis as an underlying or contributing cause of death). We calculated the age-adjusted mortality rates (AAMR) per 100 000 population, and analysis based on year, gender, race/ethnicity, state, and urban/rural classification was performed. Joinpoint regression analysis was used to determine significant annual percent changes (APCs) in AAMR over the study period. Results:A total of 242 071 deaths among the patient population were reported, and analysis revealed a significant increase in the overall AAMR for mortality related to HKD and diabetes, rising from 1.1 per 100 000 in 1999 to 4.9 per 100 000 in 2024. Men consistently showed higher AAMRs (overall 2.4) compared to women (overall 2.0). Among racial and ethnic groups, the highest overall AAMR was observed in the non-Hispanic Black or African American population (6.9). States that showed the highest AAMR included California, South Carolina, Texas, Mississippi, and the District of Columbia. Additionally, nonmetropolitan areas demonstrated a generally higher AAMR (2.6) compared to metropolitan areas (2.5). Conclusions:HKD-related mortality among diabetic Americans surged between 1999 and 2024, with gender, race/ethnicity, and geographic location disparities, especially in nonmetropolitan areas. Targeted health strategies and interventions are vital to reducing mortality and addressing these disparities.
