In this work, we propose novel electrolytes based on a low molecular weight poly(oxypropylene) (POP)/siloxane di-ureasil matrix (d-U’(400)) doped with lithium triflate (LiTrif), and/or the ionic liquid (IL) 1‑butyl‑3-methylimidazolium triflate ([BMIm]Trif), and/or carbon dots (CDs) derived from Arundo donax leaves. This multifunctional electrolyte was successfully incorporated in an electrochromic device (ECD) aiming for applications in smart windows for energy-efficient buildings. While the presence of the dopants did not compromise the amorphous nature and texture features of d-U’(400), it promoted a significant reorganization of the hydrogen-bonded network. Specifically, a reduction in disordered urea/POP aggregates and an enhancement of more ordered urea/urea ordered aggregates were observed, an effect that was particularly pronounced upon introduction of the CDs and LiTrif. The resulting electrolytes demonstrated excitation-dependent photoluminescence properties similar to those of d-U’(400), with CDs showing reduced aggregation-induced quenching. The maximum photoluminescence absolute quantum yield (8 ± 1 %) was found for d-U’(400)-CD-IL-Li. The electrochromic performance of an ECD/ was evaluated using a glass/ITO/a-WO₃/d-U’(400)-CD-IL-Li/c-NiO/ITO architecture (where ITO is indium tin oxide, a-WO3 is amorphous tungsten oxide, and c-NiO is polycrystalline nickel oxide). The device demonstrated attractive performance: high switching efficiency (transmittance variations (ΔT) of 36/21 % at 550/1200 nm), and high optical density modulation (0.33/0.38 at 550/1200 nm). High coloration efficiency (CE) was achieved at the 50th cycle (−618.87/−713.01 cm2 C−1 and +381.14/+439.12 cm2 C−1 at 550/1200 nm for coloration and bleaching, respectively), together with remarkable electrochemical stability. The ECD offers two voltage-actuated modes: bright warm (+4.0 V, ΔT = 68/36 % at 550/1200 nm) and semi-bright cold (−3.0 V, ΔT = 7/11 % at 550/1200 nm). Overall, this work contributes to current efforts toward next-generation ECD by combining an organic–inorganic electrolyte with multifunctional additives, in line with recent advances and emerging design strategies for efficient, stable, and application-oriented electrochromic systems.
Esse artigo buscou discutir sobre a doença de Chagas (DC) que configura um desafio persistente de saúde pública nas Américas, com transmissão oral destacada na Amazônia brasileira, especialmente associada ao consumo de açaí contaminado. Este estudo metodológico descreve o desenvolvimento, validação, avaliação preliminar e disseminação do livro digital (LD) “Na Floresta de Açaí”, uma tecnologia educacional ancorada nos princípios do Design Thinking Educacional e na abordagem de Saúde Única. Construído a partir de revisão bibliográfica, o LD apresenta linguagem acessível, ilustrações contextualizadas na cultura e economia amazônica, e ênfase em práticas preventivas na cadeia do açaí, sustentabilidade ambiental e vigilância participativa. Ele foi validado por 20 especialistas, alcançando índice de validade de conteúdo (IVC) para precisão científica e apresentação de conteúdo de 0,92 e 0,88, respectivamente, e pontuação de 88% na avaliação da adequação dos materiais. Na avaliação por 40 profissionais da educação e da atenção primária à saúde, obteve IVC de 0,90, com elevados índices de compreensão, atratividade, autoeficácia, aceitação cultural e persuasão. Disponibilizado gratuitamente em português, espanhol e Libras, o LD registrou 296 downloads em dois meses. Os resultados demonstram seu potencial como recurso interdisciplinar, culturalmente sensível e eficaz para a educação em saúde e prevenção da DC na Amazônia, integrando saberes científicos e locais.
] A amigdalite aguda é uma inflamação das amígdalas palatinas, geralmente de origem viral ou bacteriana, sendo uma das principais causas de atendimento na Atenção Primária à Saúde. Diante disso, este estudo buscou analisar o perfil dos atendimentos por amigdalite aguda no Vale do São Francisco, considerando os municípios de Juazeiro-BA e Petrolina-PE, no período de 2021 a 2025. Para isso, foi realizado um estudo retrospectivo, baseado em dados secundários obtidos no Sistema de Informação em Saúde para a Atenção Básica (SISAB), a partir dos registros classificados pelo código CIAP-2 R76. No período analisado, foram registrados 8.815 atendimentos, com maior concentração na faixa etária de adultos (20 a 59 anos), correspondendo a 45,09%, seguidos por crianças (0 a 9 anos), com 35,72%, adolescentes (10-19 anos), com 17,23% e idosos (60 anos ou mais), com 1,96%. Observou-se variação ao longo dos anos, com períodos de maior ocorrência, além de diferenças entre os municípios analisados, com discreto predomínio de atendimentos em Petrolina-PE. Assim, a amigdalite aguda apresenta relevante impacto na Atenção Primária à Saúde, destacando a necessidade de fortalecimento de estratégias de prevenção, diagnóstico precoce e uso racional de antimicrobianos, contribuindo para a melhoria da qualidade dos serviços de saúde.
The evolution of molecular visualization software represents a pivotal yet often underappreciated dimension of computational structural biology and bioinformatics. As the scale and complexity of structural datasets increase, spanning from cryo-electron microscopy reconstructions to proteome-wide AI-predicted models, visualization tools have become essential for data interpretation, hypothesis generation, and effective scientific communication. Widely used platforms such as PyMOL, UCSF Chimera, and emerging virtual reality environments reflect decades of progressive innovation driven by advancements in computational hardware, graphics rendering, and algorithm development. This review traces the historical development of molecular graphics software, from early vector-based applications like FRODO and O, through interactive tools including RasMol and VMD, to modern real-time 3D visualization frameworks. We highlight key technological milestones and design principles that continue to shape contemporary software architectures, underscoring the interdisciplinary collaborations among chemists, structural biologists, and computer scientists that have propelled the field. Given the current integration of artificial intelligence, immersive visualization, and cloud computing in structural bioinformatics workflows, revisiting this topic provides critical context for guiding the design of more intuitive, scalable, and accessible visualization platforms. By documenting and critically analyzing this trajectory, the present work aims to honor the foundational contributions to molecular graphics while positioning the field as a dynamic and integral component of future bioinformatics research and computational discovery.
The enzyme alkane hydroxylase is useful in the recycling of petroleum effluents or compounds from the petroleum industry, such as wastewater, waste petroleum, and low molecular weight polyethylene. However, to minimize the generation of unwanted waste and promote a safe and sustainable return to the industry, optimizing the production and purification of the enzyme is essential. The main objective of this article was to present the results related to the optimization of enzyme production and purification. Optimization was performed using response surface methodology in the Origin 2026 program. The MINITAB (R) Release 22 software was used to generate three factorial designs and perform the Response Surface Methodology analysis. To purify this enzyme, three filtration steps were applied. The optimal activities for alkane hydroxylase in petroleum and glucose substrates were 94.3 U/L and 5.64 U/L, respectively, at temperatures of 35 degrees C and 30 degrees C, pH values of 7 and 7.5, with a maximum estimated at 7.33 and optimal oxygenation of 80 %. To avoid generating unnecessary waste for the same response, it was decided to work only with PD7 in the second experimental design. Enzymatic activity varied significantly with temperature for the enzyme produced in glucose by the RA2 strain, mainly at levels of 30-37 degrees C. For PD7, this variation occurred in relation to the pre-inoculum factor. Although the optimization procedure was effective in obtaining the purified enzyme, the specific activity was low. It is believed that adding another purification step could resolve this problem.
