The Hospital Provincial de Rosario (HPR; transl. "Provincial Hospital of Rosario") is a general hospital in Rosario, Argentina, which depends on the Health Ministry of the provincial state of Santa Fe. It is a public hospital (managed partly by an elected council) and serves as the base hospital for Programmatic Area III of Zone VIII of the Santa Fe Ministry of Health.The HPR was the first hospital in Rosario and the first in the south of Santa Fe. It was inaugurated on 4 October 1855, with the name Hospital de Caridad ("Charity Hospital"), by the Sociedad de Beneficencia de Rosario ("Charitable Society of Rosario"). At the time of its foundation, the hospital was outside the main populated area of the then-small village of Rosario (which had little over 3,000 inhabitants).Presently[when?] the HPR is located in the center of the city (taking up a whole block) and serves an area with a population estimate of 386,000 residents, treating 182,000 people a year, admitting 25 patients a day, and performing 300 surgeries per month. The hospital also manages 16 primary care centers distributed in the southern part of Rosario..
Background:Early-onset colorectal cancer (EOCRC) is increasing worldwide and now accounts for a growing share of cancer deaths in younger adults. Data from middle- and low-income regions are scarce. We aimed to characterize the incidence, tumor stage distribution, lymph node positivity and metastasis patterns of EOCRC in Argentina. Methods:In this retrospective, multicenter cohort study, we analyzed adult patients who underwent colorectal cancer surgery between April 2022 and December 2023. The registry included 1829 patients, of whom 961 were male (52.5%) and 868 were female (47.5%). Mean age was 41.6 years (range 18-49) in the EOCRC group and 68.8 years (range 50-98) in the late-onset colorectal cancer (LOCRC) group. Descriptive statistics were used to summarize patient and tumor characteristics. Comparisons between EOCRC (<50 years) and LOCRC (≥50 years) were performed using χ2 tests. Ethnicity data were not available. Findings:EOCRC accounted for 15.4% of surgically treated cases, with over two-thirds occurring among individuals aged 40-49 years. Compared with LOCRC, EOCRC patients more frequently presented with advanced tumor stages (T3-T4), higher lymph node positivity, and a greater prevalence of metastases. Tumor location differed between groups, with EOCRC predominating in the rectum and LOCRC showing a right-sided predominance. Interpretation:This national multicenter surgical registry analysis reveals substantial differences in stage and metastatic burden between younger and older colorectal cancer patients in Argentina. The high prevalence of advanced disease among individuals aged 40-49 years supports consideration of earlier initiation of colorectal cancer screening. Funding:The Universidad Abierta Interamericana provided partial funding for the publication of this work.
Background: Diagnosis and treatment of systemic lupus erythematosus (SLE) are often delayed in Latin America due to barriers at the patient, provider, and health care system levels. Methods: This qualitative study, conducted in 16 countries, explored the experiences and recommendations of persons with SLE and rheumatologists to identify key needs and strategies to improve care. Semistructured interviews and focus groups were analyzed thematically. Results: Six main themes emerged: (1) education and training, (2) access to specialized care, (3) health care system organization, (4) awareness, (5) patient organizations, and (6) research. Participants underscored the need to strengthen professional competencies, decentralize care, reduce administrative barriers, and raise awareness among decision-makers and society. Conclusions: The perspectives of persons with SLE and rheumatologists converge on the urgent need for coordinated, equitable, and patient- and caregiver-centered approaches to SLE care. Implementing these recommendations—through improved education, health care system reform, advocacy, and research—could substantially reduce diagnostic and treatment delays and improve outcomes for people living with SLE in Latin America.
Background This study compared the direct costs and environmental impact associated with two general anaesthesia techniques: Total Intravenous Anaesthesia via Target-Controlled Infusion (TIVA-TCI) and sevoflurane-based anaesthesia. Methods A multicentre, observational, prospective analysis of 286 surgical patients was performed, including a TIVA-TCI group (n = 216) and a sevoflurane-based anaesthesia group (n = 70). Primary endpoints included total anaesthesia cost (converted to USD) and estimated carbon footprint (kg CO₂e) per procedure. Costs were adjusted for age and weight using ANCOVA. Results TIVA-TCI was more cost-effective, with a 25.5% reduction in total adjusted anaesthesia cost ($16.61vs. $22.31; p < .001). The environmental impact was significantly lower in the TIVA-TCI group, reducing the median carbon footprint per procedure by 93.7% (1.19 kg CO₂e vs. 18.80 kg CO₂e; p < .001). Multivariate analysis confirmed the choice of technique as a significant cost predictor. Conclusions These findings provide compelling real-world evidence supporting the adoption of TIVA-TCI as a financially and environmentally superior strategy in modern anaesthetic practice.
