Kabi Nazrul College

Introduction:: The Nuclear Factor-kappa B (NF-κB) signaling pathway plays a critical role in cancer progression by regulating inflammation, cell survival, and the spread of malignant cells to a secondary site. Emerging evidence highlights the role of microRNAs as key modulators of this pathway, influencing cancer initiation, progression, and chemoresistance. Polyphenols are natural compounds with antioxidant and anti-inflammatory properties that have demonstrated potential as anticancer agents. Methods:: In this review, we employed literature mining approaches to investigate microRNAmediated regulation of NF-κB signaling pathway activation. Furthermore, we extended our analysis to explore if polyphenols exert their anticancer efficacy as inhibitors of NF-κB signaling via miRNA targeting. Results:: The findings explore the interplay between miRNAs and NF-κB in various cancers, elucidating the dual roles of tumorigenic and tumor-suppressive microRNAs through NF-κB regulation. Additionally, it evaluates the impact of polyphenols such as soy isoflavones, tea catechins, pomegranate extracts, and more in modulating microRNA-mediated inhibition of NF-κB activation. Discussion:: This review article highlights accumulating evidence that positions dietary polyphenols as context-dependent epigenetic modulators of the microRNA–NF-κB axis in cancer. Conclusion:: In conclusion, this study directs the need for further research into polyphenol-based interventions targeting microRNA-NF-κB networks to develop effective therapies that can potentially function as cancer-preventive or anticancer strategies.

Background. Auditory and visual reaction time refers to the duration between the introduction of a sound or light and the onset of a response. It is an important aspect of human behaviour, influencing performance in various activities ranging from daily tasks to sports and emergency situations. Objectives. The purpose of this study was to investigate reaction time (auditory and visual) as a component of skill-related fitness between male college students practicing yoga and those who do not. Materials and methods. A total of forty male college-going students (N = 40) were randomly selected to participate in this study. Out of the total, twenty participants (n = 20) were dedicated yoga practitioners actively involved in district and state-level yoga competitions. The remaining twenty individuals (n = 20) followed a sedentary lifestyle and were not involved in yoga practices. The subjectsʼ ages ranged from 17 to 25 years, encompassing a cohort of young adults. The data pertaining to visual reaction time (VRT) and auditory reaction time (ART) was collected using an audio-visual reaction timer. Each participant performed the task thrice, and the mean score was used to indicate the experimental reaction time in milliseconds (ms). Descriptive statistics and the independent samples t-test were subsequently conducted to evaluate the significance level, with a predetermined threshold set at p < 0.05. Results. The results showed that the comparison between VRT and ART of yoga and non-yoga practitioners revealed that for yoga practitioners, t(38) = 2.91, and p < .006, whereas for non-yoga practitioners, t(38) = 3.55, and p < .001. Regarding VRT between yogic and non-yogic practitioners, t(38) = 1.99, and p > .054, and for ART between yogic and non-yogic practitioners, t(38) = 2.12, and p < .041. Conclusions. The findings suggest that both yogic and non-yogic practitioners demonstrated significantly lower level of ART compared to VRT. Further results indicate that hand speed in terms of VRT is nearly identical between yogic and non-yogic practitioners, but the ART of yogic practitioners was observed to be faster than that of non-yogic practitioners. Yoga has been associated with various physical and mental health benefits, and studies suggest that it may have a positive impact on reaction times.

The purpose of this study was to compare shoulder strength and leg power between Kabaddi and Athletics players. The male subjects for the study were chosen by the present researchers. The participants in the study were those who competed in inter-college district tournaments. The participants were between the ages of 18-25 years. Twenty players from each of the games Athletics (n=20) and Kabaddi (n=20) were chosen by the researchers. A simple random sampling method was used to select the 40 subjects. The researchers used the Standing Broad Jump to collect data on leg power, which was measured in meters. Pull-ups were used to test shoulder strength, and the total number of pull-ups was counted. The statistical package SPSS was used to compare shoulder strength and leg power of Kabaddi and Athletics players and used the mean, standard deviation, and independent t-test. The level of significance was set at 0.05 to test the hypothesis. The findings show that the strength of the shoulders did not differ significantly between Kabaddi and Athletics players. Also, no significant difference was found in leg power between Kabaddi and Athletics players.

One new two-dimensional heterometallic coordination polymer [Cu3Ni(L)2(CN)6]n (1) [L = 2-methylethylenediamine, CN– = cyanide ion] was synthesized and characterized by X-ray crystallography. Compound 1 crystallizes in the monoclinic C2/c space group. The single crystal X-ray structure of compound 1 indicated that it is a 2D coordination polymer with three copper(II) ion embedded with [Ni(CN)4]2- molecular ion in architecture through μ-CN/μ-NC bridges results heterometallic polymer. In compound 1, each Cu1 center with a CuN5 chromophore is encompassed by four N atoms of the two different bidentate amine (L) and one N atom of μ-NC ion, while both Cu2 and Cu3 centres are connected by three N atoms of μ-NC ions having CuN3 chromosphere and Ni1 are coordinated by three μ-CN and one terminal CN ions with NiC4 chromophore. Three copper centers and one nickel center are interlinked through μ-CN/μ-NC forming {-Cu1(L)2(μ-NC)Ni1(CN)(μ-CN)2Cu2(μ- NC)Cu3(μ-NC)-} unit to fabricate a 2D hetero metallic polymer. In the crystalline state of compound 1, each 2D polymer is further propagated through intermolecular N-H···N hydrogen bonds corroborant a supramolecular 2D network structure. Variable temperature magnetic susceptibility study displayed a weak antiferromagnetic spin coupling presumably due to the diamagnetic tetracyanonickellate bridging among the CuII ions.

AIMS: During COVID-19 pandemic, health care resources are being diverted towards the acute crisis, de-emphasizing the routine medical care. It is not only less access of health care but people also avoiding health care facilities during this pandemic. Medical care delay or avoidance might increase morbidity and mortality of treatable and preventable health conditions. Literatures have reported the decline in patient footfall and the impact of it but there is limited information on the reasons why people saying 'No' to the health care facility. Hence, we aimed to conduct this mixed method study to explore the challenges faced by the community to access & utilize the health care services during this COVID-19 pandemic. METHODS: A secondary data analysis was performed on the data obtained from hospital registers and Web Based Health Management Information System, Followed by Key informant interview on Health service providers and Focussed group discussion among the community dwellers. OPD & IPD Footfall decreased signicantly in the Health F RESULTS: acilities of Purulia District during covid pandemic in comparison to pre-pandemic time. Lowest footfall in Manbazar RH observed during the initial lock-down in 2020 & at the time of the second wave in 2021. Main reasons for decreased footfall are fear of getting covid, dissatisfaction with health care service during the pandemic, lack of transport availability, stigma attached with covid, less occurrence of disease due to IPC practices, preference of local informal providers & self-medication. CONCLUSIONS: Maintaining essential health services and behaviour change communication and de-stigmatization program is a need of hour.