Liceo de Cagayan University

BACKGROUND:Mirikizumab, an IL-23p19 monoclonal antibody, has emerged as a promising therapy for inflammatory bowel disease (IBD). However, the efficacy of different induction doses has not been comprehensively summarized. This systematic review and meta-analysis evaluated the effectiveness of mirikizumab induction therapy across multiple dose regimens at 12 weeks. METHODS:Studies assessing mirikizumab induction doses ranging from 50 to 1000 mg in IBD were systematically searched in PubMed, Embase, Scopus, Web of Science, and Cochrane Library from inception to October 2025. Outcomes included clinical remission, clinical response, endoscopic remission, and histologic remission. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a fixed-effect model. RESULTS:Across included studies, clinical remission improved significantly with 200 (OR: 5.83, 95% CI: 1.58-21.48), 300 (OR: 2.09, 95% CI: 1.44-3.02), and 900 mg (OR: 3.23, 95% CI: 2.20-4.75), while 50 and 600 mg showed nonsignificant trends. Clinical response was significantly higher for 50-, 200-, 300-, and 600-mg doses, with the strongest effect observed at 200 mg (OR: 5.89, 95% CI: 2.57-12.59). Endoscopic remission was inconsistent at low doses but significantly improved at 300 (OR: 2.13, 95% CI: 1.56-2.91), 900 (OR: 6.16, 95% CI: 3.69-10.29), and 1000 mg (OR: 16.06, 95% CI: 2.03-126.91). Histologic remission improved significantly with 200, 300, and 600 mg, while the 50-mg dose showed no meaningful benefit. Overall, mid- to high-dose mirikizumab consistently demonstrated superior efficacy compared with placebo. CONCLUSION:Mirikizumab provides dose-dependent therapeutic benefits during induction therapy in IBD. Doses of 200 to 1000 mg, particularly 300 and 900 mg, offer the most consistent improvements across clinical, endoscopic, and histologic outcomes. These findings support the use of mid- to high-dose mirikizumab as an effective induction option in patients with IBD.

This study examined men’s knowledge, religious concerns, healthcare support, and practical involvement in family planning in Barangay Tibanga, Iligan City. It was anchored in the Health Belief Model and Andersen Healthcare Utilization Model, which explain how individual perceptions, beliefs, available resources, and healthcare conditions influence participation in health-related activities. The study employed descriptive-correlational and predictive-causal research designs. Using purposive sampling with a consecutive sampling approach, data were collected from 195 married men or men in long-term relationships aged 18 to 54 years. A validated and reliability-tested survey-modified questionnaire based on the Demographic and Health Surveys Model Men’s Questionnaire was used. Data were analyzed using the mean, standard deviation, Spearman’s rho, and multiple linear regression. The findings showed high levels of knowledge regarding family planning, religious concern, and practical involvement, while healthcare support was moderately high. Men were most involved through communication, shared responsibility, and joint decision-making with their partners, but participation in public advocacy and community activities remained comparatively lower. Knowledge, religious concern, and healthcare support were significantly related to men’s practical involvement. The regression model explained 46.8% of the variance in practical involvement, with men’s inclusivity in the health service environment and awareness of contraception and misconceptions emerging as significant predictors. Religious concerns and access to family planning services were associated with involvement but did not independently predict it when the other variables were considered. The study recommends male-friendly facilities, gender-sensitive counseling, accurate family planning education, inclusive community programs, and stronger collaboration among healthcare providers, local government units, religious institutions, and couples. The study supports SDG 1 on poverty reduction, SDG 3 on good health and well-being, SDG 5 on gender equality, and SDG 17 on partnerships. Its sustainability impact lies in strengthening inclusive reproductive healthcare, shared family responsibility, culturally sensitive services, and evidence-based local health policies.

This study examined the levels of financial capability, job opportunities, and social influence, and their relationship to dropout intention among Business Administration students at selected satellite campuses of Bukidnon State University. Quantitative, descriptive, and correlational research designs were employed, using a researcher-developed questionnaire to collect data from participants. Descriptive statistics were used to determine the levels of the study variables, while Pearson Product-Moment Correlation was employed to examine their relationships with dropout intention. Results showed that participants had high levels of financial capability, job opportunities, and social influence. On the other hand, dropout intention was moderately high, with financially driven dropout intention obtaining the highest level. Financial capability was not significantly related to dropout intention, whereas job opportunities and social influence were significantly and positively related to dropout intention. These suggest that students' dropout intention is more closely associated with employment-related considerations and social influences than with their overall financial capability. The study underscores the need for responsive student support interventions addressing work-study concerns, employment decisions, and social support to strengthen educational persistence.

This study examined the levels of skills development, engagement, performance, leadership skills, and employability of Business Administration students, as well as the relationships between these variables. Using a descriptive–correlational research design, data were collected from Business Administration students through a validated survey instrument. Descriptive statistics were used to determine the levels of skills development in terms of academic technical expertise, problem-solving skills, and communication skills; engagement in terms of educational activities active involvement, self-directed learning, and collaborative learning; performance in terms of academic achievement and practical application; leadership skills in terms of decision-making, teamwork and collaboration, and interpersonal skills; and employability in terms of job acquisition skills, industry-relevant competencies, adaptability and lifelong learning, and professional attitude and work ethics. Pearson product–moment correlation was employed to examine the relationships between employability and skills development, engagement, performance, and leadership skills. Findings revealed that students demonstrated high levels across all measured variables. Moreover, significant positive relationships were found between employability and each of the four predictor variables, leading to the rejection of the null hypothesis. The results highlight that employability is closely associated with students’ academic, behavioral, and leadership-related competencies.

This study examined financial experience, financial socialization agents, financial attitude, and financial literacy among fourth-year Business Administration students from three selected higher education institutions. Specifically, it aimed to determine the levels of these variables and examine their relationships with financial literacy. A descriptive-correlational research design was employed involving 398 participants selected through purposive sampling. Data were collected using an adapted survey questionnaire and analyzed using descriptive statistics and Pearson product-moment correlation. The findings revealed that participants demonstrated moderately high levels of financial experience and financial socialization agents. Meanwhile, financial attitude and financial literacy were assessed at relatively high levels. Among the indicators, engagement in financial activities, parents and family members, savings orientation, and financial knowledge obtained the highest mean scores. Furthermore, Correlation analysis revealed significant positive relationships between financial experience, financial socialization agents, financial attitude, and financial literacy. The findings highlight that students' financial literacy is associated with their financial experience, supportive socialization, and a positive attitude toward developing financial literacy. Thus, higher education institutions, financial institutions, and government agencies are encouraged to provide financial activities and learning opportunities to further strengthen students’ financial literacy.