Mackenzie Investments was founded in 1967 and is one of Canada's largest investment management firms by assets under management. Mackenzie Investments provides investment advisory and related services for retail and institutional clients. With $201.1 billion in assets under management, Mackenzie Investments distributes its services through a diversified network of third-party financial advisors. Mackenzie Investments is a member of the IGM Financial Inc. (TSX: IGM) group of companies. IGM Financial is one of Canada's largest financial services companies by assets with over $262 billion in total assets under management.
Prior studies have challenged the practical usefulness of Markowitz portfolio optimization in improving the return–risk trade-off in portfolio management. The authors approach this question from a unique angle by examining whether one can improve the performance of a large sample of actual mutual fund portfolios by reoptimizing the holdings using simple mean–variance optimization methods. The analyses produce compelling evidence of the benefits of Markowitz optimization. Simple portfolio optimization improves mutual fund portfolios’ risk-adjusted performance despite noisy expected return estimates inferred from mutual fund portfolio weights. Several alternative optimization strategies, including the risk-parity portfolio, minimum variance portfolio, mean–variance portfolio, and Sharpe ratio maximization portfolio, all outperform actual mutual fund portfolios in terms of the Sharpe ratio and other risk-adjusted performance measures. Moreover, the results are robust to subsamples partitioned on various dimensions. In contrast to the findings of DeMiguel et al. (2009), the authors find that the 1/N portfolio performs the worst.
Este trabalho tem como proposta analisar através da doutrina e jurisprudência se é possível a exclusão de um condômino considerado antissocial em razão de reiterado comportamento antissocial à vista das limitações impostas pelo direito de propriedade, seja em razão da violação à função social, ou por vedação ao abuso do direito, ou, ainda, em prol do direito de vizinhança. Nos condomínios edilícios, dada a proximidade das unidades autônomas e do necessário convívio nas áreas comuns, devem ser adotadas medidas que prezem pela paz entre os vizinhos, que são estabelecidas pelas normas condominiais (Convenção e Regimento Interno) que buscam manter a paz e harmonia na vida condominial. Nesse contexto, o presente artigo busca analisar se, diante de comportamentos graves e reiterados, seria possível a exclusão do condômino antissocial do condomínio edilício. A cerne do presente artigo é expor as limitações do direito de propriedade em razão de sua função social, abordar o conceito de “condômino antissocial”, abordar sobre a normas condominiais e analisar a possibilidade de sua exclusão do condomínio edilício, através de dispositivos legais, posicionamentos doutrinários e decisões judiciais que versam sobre a matéria, a fim de embasar as informações coletadas e aqui apresentadas.
O preconceito racial indígena é ainda um problema na sociedade e, portanto, na educação do Brasil. A desconstrução do preconceito através de várias a práticas inclusive escolares deve ser feita desde muito cedo para que o Brasil alcance um padrão mínimo de cidadania e inclusão. Apesar de existir uma lei que determina a temática em aula ainda é um tema muito pouco explorado na educação fundamental, ficando a cargo apenas do professor do ensino médio muitas vezes apenas na aula de sociologia tentar desconstruir preconceitos, mas nessa idade preconceitos já estariam naturalizados e enraizados na cultura do aluno. Cabe iniciar a desconstrução desde a educação infantil. A intenção deste estudo é apontar uma problemática ainda muito comum no ensino infantil. Acreditamos que trazendo a voz indígena para dentro da sala de aula, através de um livro de um educador indígena esse preconceito diminua.
Psoriasis is a chronic inflammatory skin disease with multisystem involvement and associated with multiple comorbidities. It is estimated that the disease affects up to 11.4% of adults. Several factors contribute to the development and worsening of psoriasis and the identification of these factors is important to individualize therapy and achieve better therapeutic results and the quality of life for these pacients. However, epidemiological data are scarce, especially in Brazil, making clinical management difficult. The aim of the Pso.BRA study is to trace the pharmacoepidemiological profile of patients with psoriasis in Brazil. The pilot project included 97 patients over 18 years of age, of both sexes, with psoriasis diagnosed at any level of severity treated at two outpatient psoriasis services located in Curitiba (Paraná, Brazil). Regarding sociodemographic data, the mean age of patients was 55.93, with predominance of females and Caucasian. The mean age of psoriasis onset in the participants was 37, and about half of the patients reported having a family member with psoriasis. The mean number of attacks per year was 1.51 , and the psoriasis severity rating was 4.33. Around 23.7% reported dissatisfaction with treatment. Pruritus was highlighted as the greatest discomfort among patients. There was a predominance of obesity, sedentary lifestyle, and altered abdominal circumference, as well as arterial hypertension, diabetes, and high cholesterol, when compared to data from the general Brazilian population. All these associated factors bring an extra cardiovascular risk to patients and these conditions must be analyzed individually in search of control of psoriasis and comorbidities. The continuity of the study will bring data that will determine the pharmacoepidemiological profile of Brazilian patients, significantly impacting decision-making for the treatment and control of both psoriasis and associated comorbidities.
Diretrizes da Sociedade Brasileira de Cardiologia sobre Angina Instavel e Infarto Agudo do Miocardio sem Supradesnivel do Segmento ST – 2021