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Megalithic monuments in Late Neolithic Europe are often viewed as symbols of shared ancestry. In this study, we analyzed genome-wide data of 203 individuals buried in six megalithic grave complexes associated with the Western Funnel Beaker and Wartberg groups. Despite being considered archaeologically distinct, our results show that the studied individuals from both groups form a genetically homogeneous population. Moreover, we identified first- and second-degree relationships spanning up to 225 km, revealing unexpectedly long-distance ties and sustained intersite and intergroup mobility. The six grave complexes functioned as communal burial grounds and were not exclusively used for close genetic relatives, indicating that social kinship played an important role. Limited evidence for genetic connections to distant European megalithic populations indicates that monumentality spread culturally rather than through biological networks.
Abstract Background The northern European Neolithic is characterized by two major demographic events: immigration of early farmers from Anatolia at 7500 years before present, and their admixture with local western hunter-gatherers forming late farmers, from around 6200 years before present. The influence of this admixture event on variation in the immune-relevant human leukocyte antigen (HLA) region is understudied. Results We analyzed genome-wide data of 125 individuals from seven archeological early farmer and late farmer sites located in present-day Germany. The late farmer group studied here is associated with the Wartberg culture, from around 5500–4800 years before present. We note that late farmers resulted from sex-biased admixture from male western hunter-gatherers. In addition, we observe Y-chromosome haplogroup I as the dominant lineage in late farmers, with site-specific sub-lineages. We analyze true HLA genotypes from 135 Neolithic individuals, the majority of which were produced in this study. We observe significant shifts in HLA allele frequencies from early farmers to late farmers, likely due to admixture with western hunter-gatherers. Especially for the haplotype DQB1*04:01-DRB1*08:01, there is evidence for a western hunter-gatherer origin. The HLA diversity increased from early farmers to late farmers. However, it is considerably lower than in modern populations. Conclusions Both early farmers and late farmers exhibit a relatively narrow HLA allele spectrum compared to today. This coincides with sparse traces of pathogen DNA, potentially indicating a lower pathogen pressure at the time.
Abstract Inflammatory bowel disease (IBD) is often described as a model for modern civilization diseases in which environmental factors trigger disease manifestation in genetically compromised individuals. Little is known about the evolutionary history of variants associated with IBD in modern Europeans. Here, we analysed 610 IBD-variants in 2445 ancient datasets from human remains spanning the last 12,000 years, including genotypes generated from 172 newly collected individuals from the European Neolithic. We found statistically significant differences in the frequencies of 97 IBD variants between Neolithic and modern populations that can be explained by the adoption of an agricultural lifestyle and behaviour and concomitant possible microbiome changes in the earliest farmers. Later admixture events and selection against pathogens largely influenced the genetic risk architecture of IBD in contemporary Europeans. A better understanding of the evolutionary history of disease variants is an important first step in translating genetic findings into preventive health care.
Four clockwork-driven planetary automata built to show the true motion of the planets according to Ptolemaic theory, not just their mean motion, survive from the sixteenth century: one each in Paris, Vienna, Kassel, and Dresden. Close, on-site examination of their mechanisms by a team of historians of science and clockmakers has gone beyond existing accounts and revealed that, though they share a common aim, the machines differ fundamentally in their realization of even the "simplest" of the planetary motions, namely that of the Sun. Indeed, three different ways have been detected for producing the solar anomaly, the Sun's non-uniform motion along the ecliptic in the course of a year. The oldest of the surviving machines (Paris) uses the uniform motion of an eccentric gear, another (Vienna) adapts what would be a geometrically equivalent epicycle, and the two other machines (Kassel and Dresden) make use of a centered gear with non-uniformly spaced teeth. This paper discusses these findings in detail. It argues that such differing approaches not only reflect varying degrees of collaboration among the actors involved in the construction of these four technical masterpieces - princely commissioners, learned astronomers, and artful craftsmen (with these categories sometimes overlapping) - but also that they offer a further, mechanical contribution to the centuries-old reception and refinement of Ptolemaic planetary theory.
