Kavayitri Bahinabai Chaudhari North Maharashtra University is a university situated in Jalgaon, Maharashtra. Formerly North Maharashtra University was established on 15 August 1990 after separating it from the parent University of Pune.In 2001, NAAC accredited the prestigious 4-Star Status to the university. The university was re-accredited by NAAC as 'B'(CGPA 2.88 on 4 point scale) grade university. Currently during the third cycle re-accreditation by NAAC, the university has been awarded with 'A' grade (CGPA 3.
A one-pot telescopic approach has been developed for the safe, scalable, and efficient synthesis of substituted 2-arylimidazo[1,2-a]pyridines starting from commercially available and inexpensive substituted acetophenones and 2-aminopyridine. The procedure involves the in situ formation of phenacyl bromides via chemoselective bromination of acetophenones with N-bromosuccinimide, followed by nucleophilic substitution and heterocyclization with 2-aminopyridine to yield 2-arylimidazo[1,2-a]pyridines. This streamlined telescopic method avoids handling and isolation of hazardous and lachrymatory phenacyl bromides. Moreover, this synthetic protocol eliminates unit operations such as solvent extraction, solvent evaporation/distillation, and final product purification. Notably, the practical utility of this telescopic approach has been demonstrated on a gram scale, affording the product in good yields.
The escalating crisis of antimicrobial resistance demands the vital development of novel antibacterial agents with advanced mechanisms of action. This study reports the design and efficient, eco-friendly aqueous-mediated ultrasound-assisted sustainable synthesis of molecular hybrids (3a–3e) by conjugating embelin, extracted from berries of Embelia ribes (E. ribes), with phenazine nuclei, thereby exhibiting their inherent antibacterial activity. This research provided a green synthesis that was proficiently accomplished via an ultrasound-mediated methodology, offering significant advantages, including aqueous medium, shorter reaction times, higher yields, and greener chemical protocols compared to conventional methods. The synthesized derivatives were characterized using Fourier Transform Infrared Spectroscopy (FT-IR), Proton Nuclear Magnetic Resonance (1H-NMR), and High-Resolution Mass Spectroscopy (HR-MS). The synthesized compounds 3a-3e and the standard antibiotic (Ciprofloxacin) were evaluated for their in vitro antibacterial activity against the Gram-positive Staphylococcus aureus (S. aureus) (Microbial Type Culture Collection and Gene Bank) (MTCC 7443), Bacillus cereus (B. cereus)(MTCC 8750), and Gram-negative Escherichia coli (E. coli) (MTCC 724) bacteria. Several compounds 3b, 3c, 3d, and 3e demonstrated more potent and broad-spectrum antibacterial efficacy compared to the standard antibiotic. Across all three bacterial strains, the compounds exhibited inhibitory effects in the concentration range of 4–10 mg/mL. To elucidate the potential mechanism of action, molecular docking (in silico) studies were performed using AutoDock 4.2.0 against the 5-lipoxygenase enzyme (5-LOX) (PDB ID: 3V99), revealing strong binding affinities and favorable interactions within the active site conformation of synthesized compounds 3a-3e. Derivative 3b shows the highest binding energy of 7.97 Kcal/mol, and the lowest inhibition constant (1.43) than the standard drug (Zileuton) and all derivatives. The compounds 3a (binding energy 7.46 Kcal/mol), 3d (binding energy 7.66 Kcal/mol), and 3e (binding energy 7.53 Kcal/mol) have binding energies greater than 7.11 Kcal/mol of the standard drug. The stable complex formation suggests its good competitiveness as an inhibitor of the 5-LOX enzyme. Furthermore, comprehensive in silico ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) predictions indicated that all synthesized compounds (3a-3e) exhibit promising pharmacokinetic and drug-likeness properties. Collectively, the antibacterial, molecular docking, and ADMET studies identify that the synthesized compounds (3a-3e) could serve as potential inhibitors of the 5-LOX enzyme and promising antibacterial drug candidates.
A novel azo dye-based Schiff base receptors 1 and 2 were designed and synthesized via a sequence of steps and characterized by 1H NMR and single crystal X-ray crystallography. The cation recognition properties of receptor 2 were systematically investigated using fluorescence spectroscopy. Notably, receptor 2 displayed a distinct "turn-off" fluorescence response that was highly selective towards Fe3+ ions, with no significant interference from other tested cations. The binding studies revealed a detection limit as low as 2.5 mu M, demonstrating the high sensitivity of receptor 2. Furthermore, the practical applicability of receptor 2 was validated by successfully determining Fe3+ levels in a pharmaceutical drug sample. These findings highlight the design synthesis of new receptor 2 as a promising, cost-effective fluorescent receptor for the selective detection of Fe3+ ions.
Spatial nutrient heterogeneity in soil imposes distinct challenges on nutrient acquisition by plant, requiring integrated signaling and developmental processes. The review elaborates on the current understanding of how plants respond to both nutrient-deficit and nutrient-rich microsites through coordinated hormonal network, secondary metabolic adjustments, and non-hormonal signaling pathways. Major hormones and signaling molecule activity shapes root system architecture, regulates transporter activity and mediates localised and systemic responses enabling effective nutrient foraging. This review also sheds light on recent advances in peptide- and ROS-mediated nutrient sensing, and microRNA regulation, all of which contributes towards adaptation under patchy-soil condition. Moreover, nutrient heterogeneity influences accumulation of key secondary metabolites including phenolics, flavonoids, terpenoids and alkaloids which in turn supports stress tolerance and adaptive growth. We conclusively discuss the emerging strategies ranging from nanofertilisers, biostimulants, genome editing to multi-omics and AI-guided agronomy for enhancing nutrient-use efficiency. Together, these insights highlight the multi-faceted nature of plant nutrient responses and identify opportunities for improving crop resilience under varying nutrient availability.
Mixed halide perovskite films are important for various optoelectronic applications. This study involves the synthesis and characterization of mixed halide perovskite films MAPbBrxI3-x (where x = 0, 1, 2, 3), by maintaining a fixed 1:1 molar ratio of the methylammonium halide and lead halide in spin coating. The films were fabricated via the spin coating method on glass substrates. UV–visible absorption spectroscopy revealed a tunable optical bandgap ranging from 1.57 (MAPbI3) to 2.27 eV (MAPbBr3), corresponding to absorption edges that shifted from 788 to 547 nm as the bromine content increased. X-ray diffraction confirmed high crystallinity, particularly in MAPbBr2I, which exhibited the most intense and sharp peaks. SEM analysis revealed varied morphologies influenced by the halide composition, with the fixed equimolar ratio resulting in well-defined and uniform crystal structures. Notably, MAPbBr2I displayed a smooth and uniform surface, indicating superior film quality and minimized defect density. FTIR and Raman spectroscopy provided insights into molecular interactions, vibrational modes, and structural properties. This study uniquely highlights how maintaining a consistent organic-to-inorganic ratio influences the optical, structural, and morphological properties of mixed halide perovskites. The findings suggest that MAPbBr2I, with its optimal crystallinity, bandgap, and morphology, is a promising candidate for optoelectronic applications.
