Obafemi Awolowo University (OAU) is a federal government-owned university that is located in the ancient city of Ile-Ife, Osun State, Nigeria. The university was founded in 1961 and classes commenced in October 1962 as the "University of Ife" by the regional government of Western Nigeria, which was led by Samuel Ladoke Akintola, and was renamed "Obafemi Awolowo University" on 12 May 1987 in honour of Obafemi Awolowo (1909–1987), the first premier of the Western Region of Nigeria, whose idea the university was.
Purpose This study aims to find out the role of big data in the field of library and information science by considering the opportunities and challenges. Design/methodology/approach This study, which was conducted on a desk, examined the rise and significance of big data in the field of library and information science in Nigeria. Also, systematic literature review is done, exploring blogs and wikis to gather data on the use of big data. Findings This study emphasizes that as data is the primary component in the creation of information, professionals in the fields of library and information science must develop the knowledge and abilities necessary to support big data analysis. It was determined that offering and facilitating big data analysis would guarantee our place as a priceless and crucial resource in the digital workplace. Originality/value To the best of the authors’ knowledge, this study will be one of its kind to examine the role of big data in the field of library and information science profession. Furthermore, the results of the study will expose librarians and information professionals on the opportunities and challenges inherent in the use of big data technologies.
Access to agricultural credit has long been recognized as a critical determinant of farm productivity, particularly for smallholder farmers in developing countries. In Nigeria, however, restricted access to formal credit remains a significant barrier to achieving improved agricultural performance. This study examines the effect of agricultural credit access on tomato yield among smallholder farmers, with particular attention to correcting for potential selection bias associated with credit participation. Primary data were collected using a multistage sampling technique across major tomato-producing areas in Southwestern Nigeria. Descriptive statistics and the Endogenous Treatment Regression (ETR) model were employed to analyze the data. The ETR approach accounts for non-random selection into credit access by first modeling credit participation using a Probit regression, followed by a second-stage linear regression estimating the effect on tomato yield. Key explanatory variables included demographic characteristics, market access, extension services, and cooperative membership. The first-stage Probit regression revealed that age, age squared, farming experience, distance to market, access to extension services, and cooperative membership significantly influenced farmers’ likelihood of accessing credit. In the second stage, the ESR estimates showed that gender, age, age squared, farming experience, number of young dependents, market access, extension services, cooperative membership, and credit access significantly affected tomato yield. The Average Treatment Effect (ATE) of credit access on yield was 8.229, while the Average Treatment Effect on the Treated (ATT) was 8.728—both statistically significant at the 1
A series of eight spirocyclic oxindole derivatives 1a-1d, 2a-2d was synthesized according to established methods; this included the previously unreported compound, 2c. The structures of all compounds were unequivocally characterised by spectroscopic analysis (IR, 1H NMR, 13C NMR) and high-resolution mass spectrometry (HRMS). The in vitro antibacterial activity was assessed against representative Gram-positive (Bacillus subtilis, Bacillus anthracis) and Gram-negative (Escherichia coli, Pseudomonas aeruginosa) bacterial strains by determining the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The compounds exhibited a range of bactericidal effects. Notably, derivative 2c demonstrated potent, broadspectrum activity against B. subtilis, B. anthracis, and E. coli. Furthermore, both 2b and 2c exhibited significant efficacy against a clinically resistant strain of P. aeruginosa. In contrast, compounds 1a and 1d showed negligible antibacterial activity. These results underscore the potential of the spirocyclic oxindole scaffold in the development of novel antibacterial agents. This study provides a foundation for future work to optimize the structure-activity relationship and elucidate the precise mechanism of action of these compounds.
Infectious diseases remain a major public health burden in Nigeria, straining limited health resources. Effective response requires intersectoral collaboration, engaging sectors like health, education, water, and sanitation, to address underlying determinants and promote sustainable prevention strategies, especially in the face of complex, systemic health challenges. This review critically examines intersectoral collaboration for infectious disease prevention and control in Nigeria, emphasising the need for a coordinated, adaptive, and sustainable approach involving all sectors. This review adopted a narrative approach, retrieving relevant research articles from PubMed, Directory of Open Access Journal (DOAJ) and Google Scholar. Websites of the World Health Organisation and the Nigeria Centre for Disease Control and Prevention, Federal Ministries of Health, and Information (Nigeria), were consulted for relevant reports on infectious diseases prevention and control in Nigeria. The initial search yielded 146 records out of which 51 were considered eligible and included in the review. The review adopted system theory, which offered an analytical framework to facilitate the understanding of the interrelated roles and dynamics between sectors. Findings reveal that intersectoral collaboration in Nigeria is hindered by fragmented governance, poor coordination, inadequate funding, and policy misalignment. However, enabling factors include shared goals, donor support, and crisis-driven collaboration. Systems Theory highlights the interconnectedness of sectors and the importance of adaptive feedback loops, reinforcing the need for integrated strategies to strengthen collaborative responses to infectious disease challenges in Nigeria. It was concluded that strengthening intersectoral collaboration through policy reforms, sustained funding, and community engagement is essential for Nigeria’s infectious disease control. Applying systems thinking fosters resilient, coordinated actions that improve long-term health outcomes across sectors.
Introduction Calophyllum inophyllum is a medicinal plant that is extensively used in traditional Chinese medicine. Dipeptidyl peptidase IV is a diabetes mellitus enzyme that inhibits the action of key insulin-stimulating receptors. This study was designed to discover potential DPP IV inhibitors from C. inophyllum. Method A library of 140 phytochemicals was collated, and molecular docking was performed at exhaustiveness of 100. A 100 ns simulation was performed to examine the ligand’s dynamics and stability, while the selected phytochemicals’ ADMET properties were profiled using the pkCSM web server. Results Calanone (-10.2 kcal/mol), inophyllolide (-9.4 kcal/mol), brasilixanthone B (-9.4 kcal/mol), calozeyloxanthone (-9.4 kcal/mol), and calophyllin B (-9.4 kcal/mol) were identified as hit molecules against the receptor. The RMSD, RMSF, and interaction plots obtained from the molecular dynamics simulation showed that the phytochemicals exhibited good stability, while the ADMET profiling indicated that the ligands exhibited good drug candidacy properties. Discussion The study indicated that calanone, inophyllolide, brasilixanthone B, calozeyloxanthone, and calophyllin B are among the major antidiabetic compounds in C. inophyllum. A comprehensive in vitro and in vivo study is recommended for further studies.
