Pioneer Dental College & Hospital is the first and the oldest private Dental College & Hospital in Bangladesh. It was founded in 1995 at Malibag area of Dhaka. In 2007 it shifted to its present permanent campus located in Baridhara, Dhaka. This college conducted a bachelor's degree Program in Dentistry (BDS) as an affiliated dental school of Faculty of Medicine, The University of Dhaka..
Background Ovarian cancer is a leading cause of mortality among women globally. This study aimed to evaluate the diagnostic value of CA-125, HE4, and the ROMA index in identifying ovarian cancer in patients in Bangladesh. Methods This case-control study was conducted at the National Institute of Cancer Research and Hospital (NICRH) in 50 patients with histologically confirmed epithelial ovarian cancer, 25 patients with benign ovarian diseases, and 25 healthy controls. Women with prior chemotherapy or hormonal therapy, non-epithelial ovarian cancer, bilateral oophorectomy, pregnancy, or serious systemic illness were excluded. Serum CA-125 and HE4 levels were measured using Chemiluminescence Immunoassay (CLIA), and the ROMA index was calculated. Receiver Operating Characteristic (ROC) analysis was performed to assess diagnostic performance. Results The mean ages of participants were 52.5-years for ovarian cancer patients, 38.2-years for those with benign diseases, and 45.0-years for healthy controls. The median serum levels of HE4, CA-125, and ROMA index were significantly higher in ovarian cancer patients compared to controls. ROC analysis revealed AUCs of 0.95 for ROMA, 0.92 for HE4, and 0.88 for CA-125 in differentiating cancer from healthy controls, and 0.93 for ROMA, 0.94 for HE4, and 0.60 for CA-125 in differentiating cancer from benign ovarian diseases. ROMA and HE4 significantly distinguished ovarian cancer from benign conditions (p < 0.001), while CA-125 did not (p = 0.165). Conclusion In this study, the ROMA index appeared to perform better than HE4 and CA-125, though findings should be interpreted cautiously, considering the limited statistical power.
Nevoid basal cell carcinoma syndrome (NBCCS) is a rare autosomal dominant hereditary condition associated with developmental abnormalities and tumourigenesis with a prevalence rate of 1:60,000. The objective of this study was to identify NBCCS in patients diagnosed with odontogenic keratocysts (OKC) at Nair Hospital Dental College in Mumbai, India, and to compare the findings with those from Indian and international studies. Archived institutional data on OKC cases from the years 2009-2024 were analysed for NBCCS based on the criteria established by Kimonis et al. in 1997. Of the 231 cases of OKC identified, 39 (16.9%) met the diagnostic criteria for NBCCS; 27 were male and 12 were female (age range 8-55 years). Major criteria observed were OKC, palmar/plantar pits, rib anomalies, calcification of the falx cerebri, basal cell carcinomas, and a positive family history. Minor criteria included ocular hypertelorism, frontal bossing, macrocephaly, multiple pigmented nevi, syndactyly, Sprengel deformities, ovarian fibromas, and vertebral anomaly. Synophrys was found in 76.9% of cases. Analysis of criteria across countries suggests that NBCCS features in India may vary due to genetic or geographical factors The high prevalence of synophrys in this study suggests its inclusion as a new diagnostic criterion for NBCCS.
Background Differences in tooth size across populations can significantly influence dental diagnosis, treatment planning, and forensic identification. Despite its relevance, comprehensive region-specific odontometric data—particularly for the Indian population—remain limited. This study aimed to obtain odontometric measurements of permanent mandibular first and second premolars in the Indian population using cone beam computed tomography (CBCT), and to compare these measurements with Wheeler’s dental morphology standards, focusing on crown length, root length, and total tooth length. Methods In this retrospective study, 300 high-quality CBCT scans were analyzed. Measurements of crown, root, and overall tooth lengths for mandibular first and second premolars were obtained using CS 3D Imaging (Version 3.9.3). A one-sample t-test was performed to compare the mean values with Wheeler’s reference standards. Results Statistically significant differences were observed in all measured dimensions (p < 0.001). For first premolars, crown, root, and total lengths were shorter by 2.3 mm, 1.1 mm, and 3.4 mm, respectively. Second premolars showed reductions of 1.9 mm, 1.2 mm, and 3.0 mm, respectively. Conclusions This odontometric analysis highlights distinct dental morphological characteristics in the Indian population. These findings offer valuable insights for applications in anthropology, evolutionary biology, forensic science, and clinical dentistry.
