Coordinates: 22°49′28″N 75°50′57″E / 22.82444°N 75.84917°E / 22.82444; 75.84917Shri Vaishnav Vidyapeeth Vishwavidyalaya is a private university established under Madhya Pradesh Niji Vishwavidyalaya (Sthapana Avam Sanchalan) Adhiniyam in 2015 at Indore MP(India)..
In the current study , docking simulation was carried out to find the possible inhibitory potential of twenty two coumarine-triazole derivatives against Plasmodium falciparum fatty acid synthase-II ( Pf FAS-II) and forecast their ADMET properties. Their findings suggest that all of the compounds investigated may bind to the active site of the Plasmodium (PDB: 4IGF). Four (COU-11,12,15,16) of the 22 compounds were chosen based on their close proximity towards the catalytic residues viz. Tyr (180), Tyr (24), Ala(225), Ala (130), Leu (178), Ile(18) of the target site, these compounds could be regarded as oral active agents based on their physicochemical characteristics and docking outcomes. Rule of thumb was employed to the compounds COU-11, COU-12, COU-15, COU-16, since they had the best docking scores in the protein binding study (-11.81, -10.41,-10.43 & -10.94 Kcal/mol, respectively). Molecules with highest dock score were further checked for MD simulation study. This research also effectively discusses the potential benefits of coumarin-triazole derivatives as antimalarial agents, due to strong binding affinity, we are also able to anticipate a newer inhibitor against a target of interest.
This paper introduces the design of a circularly polarized (CP) single input single output (SISO) antenna, along with its 2 × 2 MIMO version, functioning within the 0.64-0.66 THz frequency range. The antenna is designed on low-loss polyimide dielectric substrates, with various slot shapes etched into radiating elements to transform linear polarization into circular polarization. A defected ground structure (DGS) is incorporated to tune the antenna’s resonance frequency at 0.65 THz. The design features low return loss, reduced mutual coupling, and a low envelope correlation coefficient (ECC). The specific absorption rate (SAR) of the antenna is also analyzed for human-body interaction. The MIMO antenna offers a -10 dB impedance bandwidth of 0.64-0.66 THz and axial ratio bandwidth (ARBW) between 0.647 and 0.666 THz. It achieves a gain of 5.76 dBi and a radiation efficiency of 88 10^-3 in the operating band. The channel capacity loss ranges from 0.07 to 0.32 bits/s/Hz within the operating band, and the mean effective gain (MEG) ranges from -2.2 to -5.7 dB in isotropic and Gaussian environments.
Tire recycling methods and environmental awareness have led to the development of products like TDA (tire-derived aggregate), a low-cost, lightweight backfill material. This research investigated the performance of isolated foundations on standard earthwork covered by TDA. A 3D finite element analysis is performed to examine the failure mechanism of shallow footings on TDA. The study found that having an underground TDA layer for shallow footings improves transmitting stresses and minimizes stress zones compared to using only standard granular backfill. TDA minimizes transmitted loads by 50
Combined Pile Raft Foundations (CPRF) have become increasingly important for high-rise buildings, yet their seismic performance on soft clay remains incompletely understood. This study investigates the dynamic behavior of CPRF systems under earthquake excitation, addressing the critical knowledge gap in soil-structure interaction effects during seismic events. Using PLAXIS 3D software, we developed a finite element model of the Messe Torhaus CPRF building in Frankfurt, Germany. The foundation system was modeled using a strain-hardening soil model for soft clay conditions, with the El Centro 1940 earthquake acceleration-time history applied to assess seismic performance. Analysis revealed maximum horizontal movements and velocities at the CPRF structure top, with peak vertical settlement at the rafting center. Quantitative results demonstrated that pile bending moments reached maximum values (74.73 kN-m) at pile heads, particularly in corner piles, decreasing by approximately 40
There are many advantages to wireless sensor networks (WSNs), but there are also some challenges associated with them. Attackers can exploit these vulnerabilities to compromise entire networks by exploiting these challenges. Our paper presents a secure WSN model that minimizes sensor node energy consumption while enduring most network attacks. A clustered network consumes less energy. Utilizing a centralized trust management system, trust levels are calculated, and trust relationships are established between reliable nodes to enhance security. It also introduces an immune system architecture tailored to WSNs based on the principles of biological immune systems. As demonstrated in experiments, the proposed WSN model balances high performance with energy efficiency, while the trust management system defends well against a variety of attacks.
