Cemented versus screw-retained implant crowns effects on peri-implant bone stability remain controversial despite widespread clinical use. Therefore, it is of interest to compare 38 cemented and 38 screw-retained single-implant crowns in posterior sites across 68 patients over 24 months. Screw-retained crowns showed significantly lower mean marginal bone loss (0.68 ± 0.29 mm vs. 1.12 ± 0.34 mm, p<0.001) at 24 months. Excess cement occurred in 34% of cemented cases, strongly correlating with bone loss (r=0.71, p<0.001). Screw retention demonstrates superior bone preservation and reduced biological complications, advancing evidence-based single-implant crown selection.
Current periodontal therapies fail to predictably restore the complete architecture of alveolar bone, periodontal ligament and cementum lost due to periodontal disease. Stem cell-based scaffolds have emerged as a biological strategy to enhance coordinated periodontal regeneration through combined cellular and biomaterial approaches. Therefore, it is of interest to evaluate preclinical and clinical evidence on dental pulp stem cell and adipose-derived stem cell-based scaffolds in periodontal regeneration. Animal studies consistently demonstrate enhanced new bone formation, cementum-like tissue deposition, organized periodontal ligament-like fibers and improved vascularization compared to scaffold-only controls. Thus, we report reductions in probing depth, gains in clinical attachment and favorable safety profiles, although standardized protocols and long-term data remain limited.
BACKGROUND:Temporomandibular joint (TMJ) disc displacement has an unclear clinical importance in temporomandibular disorders (TMD), which has been shown to vary depending on the presence of concomitant muscle disorders. OBJECTIVE:Determine differences in associations between disc displacement/muscle disorders and pain/function and quality of life (QoL). METHODS:Clinical data from 100 TMD patients were analyzed. Patients were separated into disc displacement (DD) (n = 35), muscle disorder (MD) (n = 30), and DD+MD (n = 35) groups. Pain (visual analog scale [VAS]), function (Helkimo Index), and QoL (OHIP-14) scores were compared among groups using regression models adjusted for relevant covariates. RESULTS:The DD+MD group had significantly worse pain scores, functional limitation, and QoL (p < 0.001). DD was independently associated with pain and function (but not QoL) after controlling for covariates. CONCLUSION:TMJ DD is not an independent driver of pathology but is instead amplified in the presence of muscle disorders.
Immediate implant placement challenges primary stability and osseointegration in compromised extraction sockets with large gap distances or thin buccal plates. Therefore, it is of interest to compare 40 conventional tapered implants versus 40 compressive-thread implants in 80 patients. Primary outcomes included histomorphometric bone-to-implant contact (BIC%) and bone area fraction occupancy (BAFO%) at 4 months, plus ISQ stability values. Compressive implants showed superior BIC% (68.4 ± 8.7% vs 52.3 ± 9.1%, p<0.001), BAFO% (61.2 ± 7.4% vs 48.9 ± 8.2%, p<0.001), ISQ gains and less buccal resorption (0.41 ± 0.22 vs 1.08 ± 0.39, p<0.001). Compressive macrogeometry advances immediate placement by optimizing early osseointegration and bone preservation in high-risk sites.
Background: Regenerative endodontics aims to restore the vitality and function of the pulp–dentin complex in immature necrotic teeth. Conventional approaches relying on blood clot scaffolds have shown clinical success but often yield limited regenerative outcomes. Recent advances in biomaterials and drug delivery systems have introduced bioactive scaffolds, such as simvastatin-loaded chitosan–PLGA nano hydrogels, which may enhance tissue regeneration through sustained release and biological modulation. Aim: To evaluate and compare the clinical and radiographic outcomes of a simvastatin-loaded chitosan–PLGA nano hydrogel scaffold with a conventional blood clot scaffold in regenerative endodontic procedures. Materials and Methods: This randomized controlled trial included 40 patients aged 8–16 years with immature permanent teeth exhibiting pulp necrosis and open apices. Participants were randomly allocated into two groups: Group I (experimental) received a simvastatin-loaded chitosan–PLGA nano hydrogel scaffold, while Group II (control) was treated using a conventional blood clot scaffold. Standard regenerative endodontic protocols were followed in both groups. Clinical and radiographic evaluations were conducted at baseline, 3, 6, and 12 months. Parameters assessed included pain, swelling, sinus tract, root lengthening, apical closure, and dentinal wall thickness. Statistical analysis was performed using appropriate tests with a significance level set at p < 0.05. Results: Out of 40 patients, 36 completed the study. Both groups demonstrated comparable clinical success with resolution of symptoms (p > 0.05). However, the experimental group showed significantly greater radiographic improvement in root length (p = 0.01), dentinal wall thickness (p = 0.002), and apical closure (p = 0.001) at 12 months compared to the control group. These findings indicate enhanced regenerative potential with the simvastatin-loaded scaffold. Conclusion: The use of a simvastatin-loaded chitosan–PLGA nano hydrogel scaffold significantly improves radiographic outcomes in regenerative endodontics while maintaining comparable clinical success to conventional methods. This approach represents a promising advancement in biologically driven endodontic therapy.
