Sri Venkateswara University (commonly referred as S. V. University or SVU) is a public state university located in Tirupati, Andhra Pradesh, India. The university is named after Lord Venkateswara, whose shrine is located in the city.The university was founded in 1954 by the then Chief minister of Andhra Pradesh, Tanguturi Prakasam Pantulu, with Siram Govindarajulu Naidu as its founding vice-chancellor. The university campus covers a large area on land leased by Tirumala Tirupati Devasthanams. It is located on the West side of Tirupati, surrounded by the other universities in the city, namely Sri Padmavati Mahila Visvavidyalayam, Sri Venkateswara Veterinary University, Sri Venkateswara Vedic University, Sri Venkateswara Institute of Medical Sciences and National Sanskrit University.
Objective: A green, solvent-free multicomponent synthesis of dibutyl (2-amino-3-cyano-4H-chromen-4-yl)phosphonates was developed using a homopiperazine catalyst under ultrasound irradiation to generate multifunctional scaffolds with therapeutic potential. Methods: Structural stability and electronic properties of the synthesized compounds were evaluated via Density Functional Theory (DFT). Molecular docking was performed against EGFR, HER2, MMP-9, TGFBR1, and VEGFR2, while ADMET modeling assessed pharmacokinetic profiles and toxicity risks. Biological evaluations included antioxidant, antimicrobial, and cytotoxicity assays. Results and Discussion: DFT calculations confirmed molecular stability and favorable reactivity descriptors. Molecular docking revealed potent multitarget binding affinity, particularly for compounds 4h, 4g, and 4b. ADMET analysis indicated promising drug-like profiles with acceptable toxicity. In vitro assays demonstrated potent antioxidant activity, broad-spectrum antimicrobial effects, and significant cytotoxicity against MCF-7, MDA-MB-231, DU-145, HeLa, and HepG2 cell lines. Notably, compounds 4h, 4g, 4b, 4l, and 4k exhibited superior cytotoxic efficacy compared to doxorubicin. Observed bioactivity correlated with electronic features, including MEP distribution and frontier molecular orbital energies. Conclusions: The integration of green synthesis, computational modeling, and biological validation highlights these chromenyl phosphonate hybrids as promising candidates for multitarget therapeutic applications, including oncology, oxidative stress modulation, and infectious diseases.
Expansive soils exhibit significant volume changes due to moisture variations, necessitating soil stabilization. Conventional stabilizers, such as lime and cement, have environmental drawbacks due to their carbon emissions. In this study, wollastonite powder (WP), a natural silicate mineral, and polyester fiber (PF), a synthetic reinforcing material, were used to improve the strength properties of expansive soil. Experimental investigations were conducted on the collected soil samples with varying percentages of WP (0-12
Increasing the overall efficiency of metal-air batteries and water splitting requires the development of more robust and active trifunctional (oxygen evolution reaction (OER), oxygen reduction reaction (ORR), and hydrogen evolution reaction (HER)) electrocatalysts. In this report, we synthesized ZnV2O4, Co3V2O8, and Zn2.64Co0.15V2O11H6 materials via a facile hydrothermal method and the impact of their morphologies on electrocatalyst activities was evaluated. Afterthat, the gC3N4 was added to the Zn2.64Co0.15V2O11H6 (Zn2.64Co0.15V2O11H6@gC3N4), and structural, morphological, elemental composition, and electrocatalytic properties of all the materials were analyzed. Owing to the synergistic effect of the gC3N4 with the Zn2.64Co0.15V2O11H6, the Zn2.64Co0.15V2O11H6@gC3N4 demonstrated superior trifunctional activities toward OER, HER, and ORR. The Zn2.64Co0.15V2O11H6@gC3N4 revealed excellent overpotentials (OER = 380 mV and HER = 122 mV at 20 and 10 mA cm-2, respectively) and half-wave potential (E1/2 = 0.80 V). The Zn2.64Co0.15V2O11H6@gC3N4 showed excellent stability when the chronopotentiometry test was conducted for OER and HER over 50 h and 200 h, respectively. Lastly, the Zn2.64Co0.15V2O11H6@gC3N4 was employed as an air cathode for the zinc-air battery (ZAB) to demonstrate good stability of 55 h, outperforming the Pt-C//RuO2-based ZAB. The procured OER, HER, and ORR properties of the Zn2.64Co0.15V2O11H6@gC3N4 are useful for the ZAB and water-splitting applications, which creates a new path for energy storage applications.
The annealing effect on the structural, surface topology, optical and electrical possessions of the Au/ZnPc/un-InP metal/polymer/semiconductor (MPS) diodes was investigated before and after annealing at 100 ℃, 200 ℃, 300 ℃ and 400 ℃. The structural behaviour of ZnPc films was examined by X-ray diffraction (XRD), which indicated that a phase transition occurred after annealing at 300 ℃. Furthermore, the surface topology of ZnPc films was analyzed using atomic force microscopy (AFM) and field emission scanning electron microscope (FESEM) with energy dispersive X-ray spectroscopy (EDAX) approaches before and after annealing. AFM analysis revealed that the surface roughness (root-mean-square value) increased with annealing up to 200 ℃ (6.76 nm), slightly decreased at 300 ℃ (6.70 nm), and increased again at 400 ℃ (7.60 nm). Optical studies revealed temperature-dependent shifts in Q-band absorption and enhanced Davydov splitting, while the optical band gap remained nearly unchanged. The electronic parameters of the MPS diode were evaluated before and after annealing through the current-voltage (I–V) process. The results demonstrated that the MPS diode exhibited a rectifying behavior regardless of the annealing temperature. A statistical distribution study was employed to determine the mean Φb and ‘n’ for the 20 MPS diodes before and after annealing. These outcomes point out that the Φb rises for the diode annealed at 300 ℃ (0.87 eV) and subsequently drops for annealing temperatures of 400 ℃ (0.79 eV). Further, homogeneous Φb was estimated from the relationship between experimental Φb and n for the MPS diodes before and after annealing. The interface state density (NSS) of the MPS diodes, estimated from the I-V, exhibited a decreasing trend with increasing annealing temperature up to 300 ℃ (4.59 × 109 eV−1 cm−2), followed by an increase for the diode annealed at 400 ℃ (3.50 × 1011 eV−1 cm−2). Under forward-bias conditions, ohmic conduction dominated at lower-bias regions, while space charge limited current (SCLC) predominated at higher-bias regions for the as-deposited and annealed MPS diodes at various temperatures. These findings emphasized the potential of MPS diodes to enhance the performance and reliability of organic–inorganic hybrid semiconductor devices utilized for electronic and optoelectronic applications.
In this study, the removal of Reactive Red 195, a dye commonly present in textile wastewater, was investigated using Ferric Chloride (FeCl3) and Ferric Sulfate Fe-2(SO4)(3) are as coagulants. Jar tests were undertaken to evaluate the effectiveness of the optimal coagulant dose, optimal pH, and the optimal coagulant dose at the optimal system pH for maximum colour removal. FeCl3 achieved a maximum removal efficiency of 99.9% at pH 12 using a coagulant dose of 1000 mg/L for an initial dye concentration of 50 mg/L. In contrast, Fe-2(SO4)(3) reached a maximum removal efficiency of 90% at pH 11 with a higher coagulant dose of 3300 mg/L under the same dye concentration. These compounds are undoubtedly among the best options available for high-performance applications.
