Universidad La Salle also referred to by its acronym ULSA is a private Catholic institution of secondary and higher education run by the Institute of the Brothers of the Christian Schools in 15 campuses in Mexico. It offers high school, bachelor, master and Ph.D degrees. It has had an expansion in the country, creating its own university national system. Its main campus is located in Mexico City, and has a presence in Ciudad Obregón, Chihuahua, Gomez Palacio, Monterrey, Ciudad Victoria, Leon, Morelia, Pachuca, Ciudad Nezahualcóyotl, Puebla, Oaxaca, Cancun, Cuernavaca and Saltillo.It is part of the educational community of the Brothers of the Christian Schools, founded by Saint Jean-Baptiste de La Salle, patron saint of education. The congregation has about seventy-seven thousand lay partners and one million students around the world, with establishments of higher learning in Argentina, Belgium, Brazil, Colombia, France, Guatemala, Israel, Ivory Coast, Jerusalem, Pakistan, Palestine, Philippines, Spain, the United States, and Venezuela.
El presente ensayo busca. como el título lo refiere, entablar la relación entre el habla y el silencio. Esto entendido como un vínculo que vislumbra un misterio y un cierto sentido en algunos casos de enfermos mentales, relacionando al habla con la medicina y la psiquiatría desde una perspectiva filosófica.
Background: The university social responsibility (USR) goes beyond the traditional extension and solidary social projection of the universities, but the professional must improve and develop proposals in improvement of the country. The objective is to carry out a systematic review of the scientific production related to USR in Peru and to analyse the most important findings of this production. Method: A systematic review of articles in English and Spanish in Scopus, Redalyc, and SciELO was carried out, searching for research related to USR in the Peruvian context. Articles on USR in Latin America or the world were excluded. The search and filtering of articles was carried out until February 2023. Several filters were applied, starting with the search for titles according to the search equation. Then, articles that did not deal with USR were eliminated. Subsequently, abstracts were read and those that did not meet the inclusion criteria were discarded. Finally, the remaining research was analysed to obtain the necessary information for the research. Results: A total of 20 articles were analysed. The main results showed that university social responsibility in the Peruvian context seeks to benefit society and to form ethical and responsible students. However, more policies and actions are needed to encourage the participation of all universities in USR. It was found that 65% of the literature had a quantitative approach, 30% was qualitative and only 5% was mixed. Conclusion: University Social Responsibility (USR) seeks to benefit society, being students the key actors to improve their country with the professional development acquired in higher institutions. The implication for future research is to carry out more studies on USR but within the national university centres in the highlands and jungle areas of Peru, where it is possible to show the state of this topic in other areas of Peru.
Mechanical signals are now recognized as instructive cues that guide cell fate decisions with a precision comparable to classical morphogens. The identification of genetically encoded mechanosensors-including the PIEZO and TMC ion channel families, Transient Receptor Potential channels, and mechanosensitive adhesion complexes-has revealed how cells translate forces into transcriptional programs. In this review we integrate three levels of mechanotransduction biology: the molecular sensors that detect force, the intracellular signaling networks that convert sensing into gene expression, and the multicellular dynamics by which local mechanical interactions drive tissue self-organization. We discuss how substrate stiffness, applied tension, and cell-cell mechanical coupling regulates the differentiation of stem and progenitor cells across diverse lineages, with particular emphasis on the developing cardiovascular system as a paradigmatic mechanobiological organ: primitive blood flow instructs cardiac chamber morphogenesis, and mechanosensitive channels such as PIEZO1 are essential for vascular patterning. We also examine skeletal progenitor commitment and articulate an emerging conceptual distinction-the Regeneration-Specific Mechanosensor hypothesis-proposing that a defined subset of mechanosensors is dispensable during morphogenesis but becomes essential during tissue repair, with TRPA1 as the prototypical example. Structural and computational insights into channel gating, together with engineered mechanical environments for directing stem cell fate, provide a translational bridge toward regenerative therapeutics in cardiovascular and musculoskeletal medicine. Outstanding questions include the hierarchy of mechanosensors during lineage commitment, the mechanical logic of multicellular symmetry breaking, and the translational potential of regeneration-specific mechanosensitive drug targets. We propose that integrating molecular, cellular, and tissue-scale mechanobiology offers a unifying framework for understanding cell fate decisions in both development and regenerative medicine.
Epicardial adipose tissue (EAT) has emerged as a highly active endocrine organ and a potential modulator of cardiac arrhythmogenesis. Under cardiometabolic stress, EAT undergoes a pro-inflammatory phenotypic transition. Its anatomical contiguity with the myocardium facilitates direct fibro-fatty infiltration and the continuous release of a profibrotic secretome. This process is associated with structural remodeling, connexin lateralization, and ion channel modulation, potentially creating a highly anisotropic and vulnerable substrate for both atrial and ventricular arrhythmias. Clinically, high-density electroanatomical mapping reveals that regional EAT accumulation correlates directly with low-voltage zones and fractionated electrograms, suggesting a role as both an arrhythmogenic contributor and a biophysical confounder during catheter ablation. Furthermore, non-invasive imaging (CT, CMR, TTE) and surface electrical markers, including spatial vectorcardiographic parameters, allow for advanced risk stratification. Current evidence suggests EAT may act as an active participant rather than a mere passive bystander. Targeted pharmacological interventions, such as SGLT2 inhibitors, are associated with reverse electrical remodeling alongside a reduction in EAT burden, highlighting its potential as a dynamic therapeutic target.
