Ethnopharmacological relevance Aleurites moluccanus is used in folk medicine to treat pain, fever, asthma, hepatitis, gastric ulcer and inflammatory processes in general. The A. moluccanus leaves extract has been extensively studied confirming its properties and pointing it out as a potential phytomedicine to treat pain and inflammation. However, appropriate toxicity tests are necessary to better establish the A. moluccanus safety profile to allow the inclusion of the standardized extract in subsequent clinical trials. Aim of the study This study evaluated the acute and 28-day repeated-dose oral toxicity of a standardized A. moluccanus leaf extract in rats and minipigs, following OECD guidelines. Materials and methods A. moluccanus was orally administered to rats and minipigs to evaluate the effects in the acute and 28-days sub-acute toxicity assays. Toxicological parameters were checked, including general observations, organ/body weights, food consumption, hematological and serum biochemical values and histopathological findings. Results Acute toxicity studies showed low toxicity in both species, with an LD50 greater than 5000 mg/kg in rats and greater than 1000 mg/kg in minipigs. In the 28-day repeated-dose study, male rats showed mild, non-dose-dependent reductions in body weight gain at 250 and 1000 mg/kg/day, without corroborating clinical, biochemical, or histopathological alterations; a NOAEL of 2000 mg/kg/day, the highest dose tested, was established for rats. In minipigs, the highest dose (350 mg/kg/day) induced mild gastric mucosal inflammation, identifying the stomach as the primary target organ and establishing a NOAEL of 200 mg/kg/day. The lower minipig NOAEL was used to estimate a Maximum Recommended Starting Dose of approximately 18.9 mg/kg/day for humans. Conclusions These findings indicate a favorable preclinical safety profile for the standardized extract in both rodent and non-rodent species, providing a foundation to support its continued development toward clinical trials.
This quantitative, explanatory, and quasi-experimental study evaluated the effects of Career Construction Counseling on the career adaptability of graduate students in Business Administration at a state university in Santa Catarina, Brazil. A total of 41 students participated, divided into an intervention group and a control group. The data were analyzed using analysis of covariance (ANCOVA), analysis of variance (ANOVA), and Pearson’s correlation. The results revealed significant changes in the four dimensions of career adaptability, which remained 3 months after the intervention, as well as significant correlations between adaptability and sociodemographic variables such as age, marital status, education level, and presence of children. Implications for future research and practice are discussed.
This study analyses a case of replication of ecovillages for marginalized groups in Colombia. Ecovillages are a grassroots innovation aimed at fostering sustainable communities. This paper explores how the institutional and sociocultural context shapes the replication of ecovillages in the Global South. Data was collected through fieldwork at a Colombian ecovillage and interviews with members of organizations engaged in replicating the ecovillage’s model. The results show that the sociocultural context influences replication through reframing dynamics. Reframing dynamics involves two steps: An initial frame alignment followed by shifts in the collective action frames. The interpretative flexibility of the ecovillage concept enables its adaptation to diverse sociocultural contexts. However, in the Global South, limited economic resources, weak state institutions, and uneven access to knowledge can compel marginalized groups to rely on brokers with the knowledge and political leverage to mobilize the necessary resources. Despite these challenges, interviewee accounts suggest that rural ecovillages with social (subsidized) housing may offer a viable solution for marginalized groups in the Global South seeking to integrate economic productivity, ecological sustainability and a strong sense of community.
Este artigo analisa como experiências turísticas com potencial transformativo se relacionam com oscilações no bem-estar em um contexto de crise. A pesquisa fundamenta-se na Teoria da Aprendizagem Transformativa e no modelo PERMA, adotados como lentes teórico-analíticas para compreender processos de desorientação, autorreflexão e construção de significado vivenciados por turistas que viajaram no início da pandemia da Covid-19. Trata-se de um estudo qualitativo, baseado em entrevistas semiestruturadas em profundidade com viajantes brasileiros, analisadas por meio de análise de conteúdo. Os resultados evidenciam que as experiências turísticas vividas em contextos de crise são marcadas por oscilações no bem-estar hedônico e eudaimônico, associadas a promotores e redutores de bem-estar, e que o processo transformativo não decorre exclusivamente da intensidade dos eventos vivenciados, mas dos processos interpretativos e da construção de significado atribuída pelos próprios turistas. A partir dos achados empíricos, o estudo propõe uma síntese conceitual das experiências turísticas transformativas em contextos de crise, destacando o caráter não linear e contingente desses processos. O artigo contribui para o avanço teórico ao integrar aprendizagem transformativa, bem-estar e turismo em situações extremas, oferecendo subsídios para pesquisas futuras e implicações relevantes para a gestão do turismo em contextos de instabilidade.
O patrimônio cultural relaciona-se à uma memória social e liga passado, presente e futuro. Assim, a valorização da história e cultura local colabora para a constituição da memória coletiva e fortalece o pertencimento. Os objetos de estudo são o Palácio Araguaia, sede do Governo do Estado e o Memorial Luiz Carlos Prestes com o objetivo de analisá-los enquanto patrimônios e seus uso turísticos. A pesquisa é qualitativa e exploratória utilizando as categorias de Drummond (2004) para avaliar os fatores críticos que influenciam a visitação a patrimônios e a análise dos dados fundamentada em Geertz (2017). Os resultados confirmam a importância dos bens enquanto patrimônio cultural e sua relevância enquanto atrativo turístico, dada a relevância histórica. Contudo necessitam de ações de conservação física e aperfeiçoamento das técnicas de interpretação do acervo para aproximar a comunidade e fomentar o turismo.
