This study investigates how working conditions impact the physical and psychological suffering of Military Police officers in Baixada Fluminense, Rio de Janeiro, focusing on the role of occupational suffering in mental health distress. A quantitative field study was conducted with 61 active Military Police officers using a questionnaire based on Christophe Dejours’s Psychodynamics of Work theory. Data were analyzed using descriptive and inferential statistics, including chi-square tests to identify associations between working conditions and health outcomes. Findings reveal that precarious working conditions, such as inadequate protective equipment, excessive workloads, and exposure to violence, contribute significantly to physical and psychological illnesses among officers. Anxiety, depression, and somatic symptoms like chronic fatigue and circulatory problems were prevalent. The study demonstrated strong statistical links between work-related stressors and the need for medical care addressing physical, emotional, and psychological disorders. The escalating intensification and systemic precarization of police labor significantly amplify occupational suffering, precipitating deleterious physical and psychological health outcomes among Military Police officers. Urgent institutional interventions are imperative to enhance working conditions, bolster comprehensive support mechanisms, and foster mental well-being, thereby mitigating these adverse effects and promoting sustainable workforce resilience.
Metronidazole (MTZ) remains the main treatment for Trichomonas vaginalis infections; however, increasing resistance has driven the search for more effective therapeutic alternatives. In this study, we prepared and characterized three metal-based metronidazole complexes: [Zn(MTZ)2Cl2], [Cu(MTZ)2μ-Cl(H2O)]2Cl2, and [Cu(MTZ)(PPh3)2(NO3)]‧ H2O, (MTZ = metronidazole; PPh3 = triphenylphosphine). Single-crystal X-ray diffraction confirmed the coordination of MTZ by the N-imidazole and auxiliary ligands of the metal centers. The [Zn(MTZ)2Cl2] complex demonstrated significant antiproliferative activity against T. vaginalis, with an IC50 of 1.7 μM after 24 h, surpassing that of free MTZ. Similar potency was observed for copper-MTZ complexes. Ultrastructural analyses via scanning and transmission electron microscopy revealed membrane blebbing, cytoplasmic vacuolization, and hydrogenosomal disorganization, morphological hallmarks of apoptosis-like cell death. These findings were further supported by TUNEL and Annexin V assays, indicating DNA fragmentation and phosphatidylserine exposure. Cytotoxicity assays using HMVII human cells showed low toxicity for MTZ, [Zn(MTZ)2Cl2], and [Cu(MTZ)2μ-Cl (H2O)]2Cl2 (CC50 > 100 μM), whereas the [Cu(MTZ)(PPh3)2NO3]‧H2O complex was markedly cytotoxic (CC50 = 3.35 μM). The results suggest that MTZ-based zinc and copper complexes enhance antiparasitic efficacy with acceptable safety profiles. These findings provide a promising foundation for developing novel treatments for drug-resistant trichomoniasis.
AIM:To map research on nursing workforce preparedness and resilience in health emergencies from 2000 to 2025 and propose an integrated framework. DESIGN:Bibliometric review with science mapping and thematic evolution. METHODS:Scopus was searched for journal articles and reviews on nursing workforce preparedness and resilience in health emergencies published from 2000 to 2025. Records were screened using year, language, document type, duplicate title, and metadata-based scope criteria. Co-citation and co-word analyses were conducted to map intellectual foundations and conceptual structures. Time-sliced analysis examined thematic evolution across 2000-2009, 2010-2019, and 2020-2025, while emerging hotspots were identified using keyword growth and recency indicators. RESULTS:The final retained corpus included 7570 documents, composed of 6950 articles and 620 reviews. Publication output showed a marked post-2020 surge. Co-citation analysis highlighted intellectual foundations related to disaster nursing competence, psychological resilience and mental health, leadership, staffing, safety, and workforce systems. Co-word analysis indicated major domains of clinical competence, emergency and acute-care delivery, pandemic-related psychological burden and resilience, workforce organization and emergency service capacity, and nursing education for disaster preparedness. Emerging hotspots included burnout, moral distress, resilience, telemedicine, mental health, and qualitative inquiry. CONCLUSION:Nursing workforce preparedness research has evolved into a multidimensional, system-oriented agenda that integrates competence, resilience, and structural readiness. IMPLICATIONS FOR NURSING MANAGEMENT:Nurse managers should treat emergency preparedness as a strategic workforce-management responsibility, not only as a clinical or disaster-planning task. The findings support competency-based preparedness training, workforce policies for surge staffing and role deployment, organizational capacity building, mental health and resilience supports, leadership preparation, safety infrastructure, and data-informed preparedness planning to sustain nursing performance during future health emergencies.
Aneurysmal subarachnoid hemorrhage (aSAH) causes substantial morbidity and mortality, and guidelines recommend aneurysm repair as early as feasible. However, the association between onset-to-treatment time and outcomes remains uncertain. This review synthesized evidence across multiple clinical outcomes and examined whether treatment modality modifies this association. Searches were conducted in PubMed/MEDLINE, Scopus, and LILACS for studies comparing clinical outcomes across different onset-to-treatment windows in adults with confirmed aSAH. Findings were synthesized narratively according to the Synthesis Without Meta-analysis (SWiM) guideline. The review was prospectively registered in PROSPERO (CRD420261415084). Twenty reports comprising 11,096 participant records were included, with likely overlap between two reports. Treatment categories ranged from <6 h to ≥15 days. Earlier securement likely reduced pretreatment rebleeding, particularly when untreated or markedly delayed patients were included, although treated-cohort comparisons were inconsistent. More methodologically informative adjusted analyses showed no reproducible independent association between treatment timing and functional outcome or mortality. No consistent association emerged for vasospasm or related cerebral ischemia, hydrocephalus, or length of stay. Two observational studies modeled time continuously: one found a significant U-shaped mortality association with an estimated nadir at 32.6 h, whereas the other showed a similar but non-significant adjusted pattern with an estimated nadir near 12.16 h. These findings are highly susceptible to confounding by indication and survivor bias and do not establish benefit from treatment delay. Three studies formally tested modality-timing interaction; one found a significant mortality interaction and two did not. Additional stratified analyses showed no consistent modality-specific pattern. Certainty of evidence for the timing-mortality association was very low because of serious risk of bias, inconsistency, and imprecision. Earlier aneurysm securement remains supported for preventing pretreatment rebleeding. The independent association of treatment timing with mortality or functional outcome remains uncertain. The observed mortality patterns are hypothesis-generating and do not define a validated therapeutic window, support intentional treatment delay, or justify changing current guideline recommendations. Prospective multicenter studies using continuous-time modeling and rigorous methods to address confounding and survivor bias are needed.
Este artigo investiga a relação entre a cultura e uma universidade indígena, analisando os desafios e as possibilidades presentes nas ações da Universidade Pluriétnica da Aldeia Marakanã na concepção, organização, produção e execução do evento Transfluências de Saberes. A pesquisa deste artigo busca compreender como a Universidade Indígena, em compartilhamento de saberes, mas protagonizando os processos, pode contribuir para a (re)existência cultural, a decolonização do conhecimento e a formação de lideranças indígenas. A partir de uma revisão da literatura e com um olhar particular para a relevância do Transfluências de Saberes, buscamos compreender de que modo iniciativas que promovem o encontro entre saberes originários/tradicionais, acadêmicos e políticos, como este evento, podem contribuir para a construção de um espaço mais decolonial para a universidade ocidentalizada, visando que a academia possa abarcar os saberes silenciados pelo epistemicídio histórico e corrente. Costurado em três vozes femininas: uma antropóloga, uma psicanalista e uma liderança indígena, o artigo discute a importância da interculturalidade, da autonomia indígena e da articulação entre os saberes tradicionais e os conhecimentos acadêmicos.
