Objective To analyse and explore the effect of early skull defect repair after craniocerebral trauma operation on prognosis of the patients.Methods Randomly selected in our hospital early cranioplasty(early group) and late cranioplasty(late group) of the 28 cases,respectively,and recovery and postoperative neurological function were compared between two groups after 2 months when the incidence of adverse reaction.Results The early group 2 months after operation the KPS score(81.69±12.68) points,significantly better than the late group(71.56±14.3) points(P0.05);the early group GOS prognostic evaluation also was better than the late group(P0.05);complications compared with the early group of five cases,the late group of six cases.The two groups showed no significant difference(P0.05).Conclusion The application of post-operative craniocerebral trauma skull defect in the treatment of early cranioplasty is better than late cranioplasty.
Objective:To analyze the curative effects of CT-guided ozone injection combined with radiofrequency thermocoagulation on lumbar disc herniation.Methods:Seventy patients with lumbar disc herniation admitted to Zhumadian Central Hospital from January 2021 to January 2023 were selected and divided into control group and observation group according to random number table method, with 35 cases in each group. The control group received CT-guided radiofrequency thermocoagulation, and the observation group received CT-guided ozone injection combined with radiofrequency thermocoagulation. The excellent and good rate, Japanese Orthopaedic Association (JOA) score, Oswestry disability index (ODI) score, numerical rating scale (NRS) score and incidence of adverse reactions of the two groups were compared.Results:The excellent and good rate of the observation group was 97.14% (34/35), higher than the 71.43% (25/35) of the control group ( P<0.05). After treatment, the JOA score in the observation group was higher than that in the control group, while the ODI score was lower than that in the control group ( P<0.05). After treatment, the NRS score of the observation group was lower than that of the control group ( P<0.05). There was no significant difference in the incidence of adverse reactions between the observation group (2.86%, 1/35) and the control group (17.14%, 6/35), P>0.05. Conclusions:CT-guided ozone injection combined with radiofrequency thermocoagulation, in the treatment of lumbar disc herniation, can improve the excellent and good rate, reduce pain degree and improve lumbar function.
Objective:To observe the effect of transcranial focused ultrasound stimulation combined with cognitive training on the rehabilitation of patients with severe head injury.Methods:This study was s prospective cohort trail. A total of 80 patients with severe head injury who received rehabilitation treatment in the First Affiliated Hospital of Zhengzhou University from January 2021 to December 2022 were selected as the research objects. They were divided into control group and observation group by random number table method, with 40 cases in each group. The control group received cognitive training, while the observation group received transcranial focused ultrasound stimulation based on the intervention of the control group. The serum indicator brain-derived neurotrophic factor (BDNF), neurological function assessed by National Institute of Health stroke scale (NIHSS) and modified Rankin scale (mRS), cognitive function assessed by Montreal cognitive assessment (MoCA) score, and self-care ability assessed by activity of daily living scale (ADL) score were compared between the two groups before and after treatment.Results:After treatment, the BDNF level, MoCA score, and ADL score in the two groups were higher than those before treatment, and the above indicators in the observation group were higher than those in the control group ( P<0.05). After treatment, the NIHSS score and mRS score of the two groups were lower than those before treatment, and the observation group had lower scores of NIHSS and mRS than the control group ( P<0.05). Conclusions:The combination of transcranial focused ultrasound stimulation and cognitive training can effectively improve neurological and cognitive function, and enhance self-care ability in patients with severe head injury.
Objective:To compare the clinical effect of closed reduction interlocking intramedullary fixation and internal fixation with plates and screw in the treatment of traumatic fractures of long tubular bone in the limbs.Methods:A total of 70 patients with traumatic fracture of long tubular bone in th limbs admitted to Puyang People’s Hospital from January 2021 to January 2023 were selected, and all the patients were divided into control group and observation group by random number table method, with 35 cases in each group. The control group was treated by closed reduction interlocking intramedullary fixation. The observation group was treated by internal fixation with plates and screw. The excellent and good rate of fracture healing, surgical indicators, incidence of complications, and degree of pain were compared between the two groups.Results:The excellent and good rate of fracture healing in the observation group (94.29%, 33/35) was higher than that in the control group (77.14%, 27/35), P<0.05. The intraoperative bleeding in the observation group was less than that in the control group, moreover, the fracture healing time, surgical time, and hospital stay were all shorter than those in the control group ( P<0.05). The incidence of complications in the observation group (2.86%, 1/35) was lower than that in the control group (20.00%, 7/35), P<0.05. After treatment, the visual analogue scale score of the two groups decreased, compared with preoperative scores ( P<0.05); and the observation group had lower visual analogue scale score than the control group after treatment ( P<0.05). Conclusions:The internal fixation with plates and screw has a good effect in the treatment of patients with traumatic fractures of long tubular bone in the limbs, which can effectively promote patient recovery, reduce complications, and alleviate pain.
Objective:To investigate the effect of nifedipine combined with labetalol on gestational hypertension and its influence on serum alkaline phosphatase (ALP) level, leucine aminopeptidase (LAP) level, and blood coagulation function.Methods:A total of 104 patients with gestational hypertension admitted to the First People’s Hospital of Zhumadian from March 2021 to April 2022 were selected, and they were divided into control group and observation group by random number table method, with 52 cases in each group. The control group was treated with labetalol, and the observation group was treated with nifedipine combined with labetalol. Both groups were treated for 10 days continuously. The clinical efficacy, levels of serum ALP and LAP, blood pressure level, coagulation function, which was assessed by thrombin time (TT), prothrombin time (PT), activeated partial thromboplasting time (APTT) and fibrinogen (FIB), pregnancy outcomes, and incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group (94.23%, 49/52) was higher than that of the control group (78.85%, 41/52), with a statistically significant difference ( P<0.05). After treatment, the levels of serum LAP and ALP in the observation group were (12.86±3.02) U/L and (265.69±50.26) U/L, respectively, which were higher than the (11.53±2.81) U/L and (230.71±40.38) U/L in the control group ( P<0.05). The diastolic blood pressure and systolic blood pressure in the observation group were (84.61±6.29) mmHg 1 mmHg=0.133 kPa and (105.44±7.82) mmHg, respectively, which were lower than the (92.14±7.65) mmHg and (115.51±8.43) mmHg in the control group ( P<0.05), correspondingly. The PT, APTT, and TT in the observation group were all longer than those in the control group, while the FIB was lower than that in the control group ( P<0.05). The incidence of adverse pregnancy outcomes in the observation group (3.85%, 2/52) was lower than that in the control group (19.23%, 10/52), with a statistically significant difference ( P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups ( P>0.05). Conclusions:Nifedipine combined with labetalol has a good effect on patients with gestational hypertension. It can regulate the levels of serum ALP and LAP, reduce blood pressure, improve blood coagulation function and adverse pregnancy outcomes, and reduce the incidence of adverse reactions.
Objective:To analyze the clinical efficacy of propafenone combined with Shensong Yangxin capsule in the treatment of premature ventricular contraction (PVC) in children.Methods:A total of 90 children with PVC treated in Children’s Hospital Affiliated of Zhengzhou University from January 2020 to December 2022 were divided into control group A (30 cases), control group B (30 cases) and observation group (30 cases) by random number table method. The control group A was treated with propafenone, the control group B was treated with Shensong Yangxin capsule, and the observation group was treated with propafenone combined with Shensong Yangxin capsule. The treatment efficacy, preoperative and postoperative dynamic electrocardiogram manifestations (24 h PVC frequency and heart rate), and incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 96.67% (29/30), higher than that of the control group A (70.00%, 21/30) and the control group B (66.67%, 20/30), P<0.05. Compared with the control group A and the control group B, the 24 h PVC frequency and heart rate in the observation group were lower ( P<0.05). There was no significant difference in the incidence of adverse reactions among the observation group (6.67%, 2/30), the control group A (16.67%, 15/30) and the control group B (13.33%, 4/30), P>0.05. Conclusions:Propafenone combined with Shensong Yangxin capsule is effective in the treatment of children with PVC, which can improve the clinical symptoms of children, and reduce the frequency of PVC and heart rate, without obvious adverse reactions.
Objective:To detect the levels of serum C-reactive protein (CRP), interleukin-6 (IL-6) and hepatitis B virus deoxyribonucleic acid (HBV-DNA) viral load in patients with chronic hepatitis B virus (HBV) infection, and analyze the correlation of levels of serum CRP and IL-6 with HBV-DNA viral load in HBV infected patients.Methods:This study was a prospective study, including 80 patients with HBV infection treated in Nanyang Central Hospital from October 2019 to October 2021. Blood samples of selected patients were collected at admission, and serum CRP, IL-6, HBV-DNA load were measured. Patients were divided into negative group, low load group, medium load group and high load group according to HBV-DNA test results. The laboratory indexes of patients with different HBV-DNA viral load were compared. And the correlation of serum CRP and IL-6 with HBV-DNA viral load in patients with HBV infection was analyzed by Pearson correlation and logistic regression analysis.Results:Among the 80 patients with HBV infection, 12 cases were negative, and 68 cases were positive for HBV-DNA. Among the 68 positive samples, 31 cases were with low load, 22 cases were with medium load, and 15 cases were with high load. There were significant differences in levels of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin, total bilirubin, CRP and IL-6 between HBV infected patients with different HBV-DNA viral loads ( P<0.05). The results of Pearson correlation analysis showed that serum CRP and IL-6 were positively correlated with HBV-DNA viral load in HBV infected patients (all r>0, all P<0.05). Results of Logistic regression analysis showed that serum CRP and IL-6 were correlated with HBV-DNA viral load in HBV infected patients ( P<0.05). Results of Pearson correlation analysis showed that serum CRP was positively correlated with IL-6 in HBV infected patients ( r>0, P<0.05). Conclusions:Serum CRP and IL-6 are related to HBV-DNA viral load in HBV infected patients. The changes of HBV-DNA load in HBV infected patients can be monitored by detecting levels of serum CRP and IL-6.
Objective:To compare the effects of percutaneous pedicle screw fixation (PPSF) and reduction combined with internal fixation through transvertebral space (Wiltse) approach on thoracolumbar fractures without neurological symptoms.Methods:A total of 56 patients with thoracolumbar fractures without neurological symptoms admitted to Zhengzhou Orthopedic Hospital from March 2018 to March 2022 were selected, and the patients were divided into PPSF group and Wiltse group according to the surgical plan, with 28 cases in each group. The efficacy indicators, surgical indicators and postoperative pain visual analogue scale (VAS) scores were compared between the two groups.Results:Three months and 1 year after treatment, the height ratio of anterior margin of injured vertebra in the two groups were higher than those before treatment, moreover, their Cobb angle and Oswestry disability index scores were lower than those before treatment, with significant differences ( P<0.05). There was no statistically significant difference in the efficacy indicators between the two groups ( P>0.05). The incision length of the PPSF group was shorter than that of the Wiltse group, while the intraoperative blood loss of the PPSF group was less than that of the Wiltse group, moreover, the operation time and intraoperative X-ray fluoroscopy time of the PPSF group were longer than those of the Wiltse group ( P<0.05). The VAS scores of the PPSF group were lower than those of the Wiltse group 1, 3, and 7 days after surgery ( P<0.05). Conclusions:PPSF and reduction combined with internal fixation through Wiltse approach have similar effects in the treatment of thoracolumbar fractures without neurological symptoms. PPSF is more minimally invasive, while surgery through Wiltse approach can reduce X-ray fluoroscopy time and reduce the operation less difficult.
Objective:To investigate the effect of intravenous anesthesia and inhalation anesthesia in endoscopic sinus surgery (ESS) for chronic sinusitis.Methods:A total of 130 patients with chronic sinusitis who underwent ESS in Central Hospital of Jiaozuo Coal Industry Co., Ltd. from February 2020 to January 2022 were selected, and they were divided into total intravenous anesthesia group and inhalation anesthesia group randomly, with 65 cases in each group. Total intravenous anesthesia was used in the total intravenous anesthesia group, and inhalation anesthesia was used in the inhalation anesthesia group. The perioperative indexes of two groups were compared. The airway peak pressure, airway resistance, lung compliance and plateau pressure were compared between the two groups in different time periods, such as before tracheal intubation (T0), 5 minutes after tracheal intubation (T1), 30 minutes after tracheal intubation (T2), 1 hour after tracheal intubation (T3), and at the end of surgery (T4).Results:There were no significant differences between the total intravenous anesthesia group and the inhalation anesthesia group in intraoperative blood loss, bleeding velocity, mean arterial pressure and intraoperative heart rate ( P>0.05). There were no significant differences in airway peak pressure, airway resistance, lung compliance and plateau pressure between the total intravenous anesthesia group and the inhalation anesthesia group at T0, T1, T2, T3 and T4 ( P>0.05). Conclusions:Total intravenous anesthesia and inhalation anesthesia have the same effect in ESS for chronic sinusitis, both of them can reduce intraoperative blood loss and bleeding speed, and don’t have significant effects on respiratory indicators, such as airway peak pressure, airway resistance, lung compliance and plateau pressure. Both anesthesia methods can be applied in this surgery.
Objective:To analyze the factors influencing the formation of bone bridges after simple internal fixation for thoracolumbar fractures.Methods:A total of 95 patients with thoracolumbar fractures admitted to the First Affiliated Hospital of Zhengzhou University from March 2021 to March 2023 were selected, and the patients were divided into bone bridge group (38 cases) and non-bone bridge group (57 cases) according to development of bone bridge. The general and clinical data of the participants were collected. The influencing factors of bone bridge formation after simple internal fixation of thoracolumbar fractures were analyzed by multivariate logistic regression model.Results:The rate of postoperative vertebral height ≤70%, spinal hyperplasia rate and incidence of eggshell-like vertebrae in the bone bridge group were higher than those in the no bone bridge group ( P<0.05). Results of multivariate logistic regression analysis showed that spinal degenerative hyperplasia≥3 segments and postoperative eggshell-like vertebrae formation were independent risk factors for bone bridge formation after simple internal fixation of thoracolumbar fractures ( P<0.05). Conclusions:Spinal degenerative hyperplasia≥3 segments and postoperative eggshell-like vertebrae formation are independent risk factors for bone bridge formation after simple internal fixation of thoracolumbar fractures, and targeted preventive measures should be given to avoid postoperative bone bridge formation.
Objective:To investigate the application value of butylphthalide soft capsule combined with aspirin in the treatment of acute cerebral infarction.Methods:A total of 92 patients with acute cerebral infarction treated in Nanyang Central Hospital from August 2019 to October 2021 were selected, and they were divided into control group and observation group according to the random number table method, with 46 cases in each group. The control group was given aspirin, and the observation group was given butylphthalide soft capsules combined with aspirin. The clinical efficacy and incidence of adverse reaction of the two groups were compared. The levels of serum inflammatory factors, including C-reactive protein (CRP) and interleukin-10(IL-10), neurological function assessed by American National Institutes of stroke scale (NIHSS) score, cognitive function assessed by mini-mental state examination (MMSE) and Montreal cognitive assessment (MoCA) scores, and blood perfusion level were compared between the two groups before and after treatment.Results:The total effective rate in the observation group (95.65%, 44/46) was higher than that in the control group (80.43%, 37/46), and the difference was significant ( P<0.05). After treatment, the levels of CRP and IL-10 in the observation group were lower than those in the control group ( P<0.05). After treatment, the observation group had lower NIHSS score and higher Barthel index, compared with the control group ( P<0.05). After treatment, the scores of MMSE and MoCA in the observation group were higher than those in the control group ( P<0.05). After treatment, the cerebral blood flow and cerebral blood volume in the observation group were higher than those in the control group ( P<0.05). There was no significant difference in the incidence of adverse reactions between the observation group (6.52%, 3/46) and the control group (13.04%, 6/46), P>0.05. Conclusions:Butylphthalide soft capsules combined with aspirin in the treatment of acute cerebral infarction can improve clinical efficacy, relieve inflammation reaction, and improve neurological function, blood perfusion and cognitive function, with great safety.
Objective:To analyze the idiopathic effect of mycophenolate mofetil and cyclosporine A in combination with prednisone on idiopathic refractory nephrotic syndrome.Methods:A total of 76 patients with idiopathic refractory nephrotic syndrome treated in Zhumadian Central Hospital from January 2021 to January 2023 were selected, and they were randomly divided into study group and conventional group, with 38 cases in each group. The conventional group was treated with mycophenolate mofetil combined with prednisone, and the study group was treated with cyclosporine A combined with prednisone. The therapeutic effect, renal function, which was assessed by urinary protein (Pa), blood creatinine (Scr), uric acid (UA) and blood urea nitrogen (BUN), the levels of urinary renal injury molecule 1 (KIM-1), level of neutrophil gelatinase-associated lipocalin (NGAL), immune function assessed by cluster of differentiation 4 + (CD4 + ) and cluster of differentiation 8 + (CD8 + ), level of platelet activating factor hydrolase (PAF-AH), levels of platelet activating factor (PAF), and the incidence of adverse reactions were compared between the two groups. Results:The total effective rate of the study group was 94.74% (36/38), which was higher than the 76.32% (29/38) of the conventional group ( P<0.05). After treatment, the levels of Pa, Scr, UA, and BUN in the study group were lower than those in the conventional group ( P<0.05). After treatment, the levels of KIM-1 and NGAL in the study group were lower than those in the conventional group ( P<0.05). After treatment, the CD4 + level in the study group was lower than that in the conventional group ( P<0.05), while there was no significant difference in CD8 + level between the two groups ( P>0.05). After treatment, the level of PAF-AH in the study group was higher than that in the conventional group, while the level of PAF was lower than that in the conventional group ( P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups ( P>0.05). Conclusions:Compared with mycophenolate mofetil combined with prednisone, the combination therapy of cyclosporine A with prednisone for idiopathic refractory nephrotic syndrome can improve the clinical efficacy, decrease the levels of KIM-1 and NGAL, regulate the levels of T lymphocyte subsets, PAF-AH and PAF. Moreover, it can significantly improve renal function, with safety.
Objective:To investigate the application of proprioceptive neuromuscular facilitation (PNF) combined with isokinetic muscle strength rehabilitation in postoperative rehabilitation of total knee arthroplasty (TKA) for knee osteoarthritis.Methods:A total of 102 patients with knee osteoarthritis treated in Fuwai Central China Cardiovascular Hospital and Henan Provincial People’s Hospital from January 2018 to June 2020 were selected as the object of study. All patients were treated by TKA, and the patients were divided into observation group and control group by random number table method, with 51 cases in each group. The control group was given PNF for rehabilitation, and the observation group performed isokinetic muscle strength rehabilitation based on the inertvention of the control group. The recovery condition assessed by Knee Western Ontario and McMaster University Osteoarthritis Index (WOMAC), knee flexor and extensor isokinetic muscle strength assessed by peak torque (PT), time to peak torque (TPT), average power (AP) and peak torque/body weight (PT/BW), and knee mobility assessed by Japanese Orthopaedic Association (JOA) knee osteoarthritis score and knee range of motion (ROM), of the two groups were compared and analyzed.Results:After treatment, the WOMAC scores of the two groups decreased, and the WOMAC scores of the observation group were lower than those of the control group ( P<0.05). After treatment, the PT, AP and PT/BW of the flexor and extensor muscles in the two groups were improved, whlie PT, AP and PT/BW of the flexor and extensor muscles in the observation group were higher than those in the control group ( P<0.05). After treatment, the TPT of the flexor and extensor muscles in the two groups was decreased, and TPT of the flexor and extensor muscles in the observation group were lower than those in the control group ( P<0.05); the JOA score and ROM of the two groups were improved, and the JOA score and ROM of the observation group were significantly higher than those of the control group( P<0.05). Conclusions:The application of PNF technique combined with isokinetic muscle strength rehabilitation after TKA for knee osteoarthritis can effectively improve knee joint recovery, improve knee flexion and extensor isokinetic muscle strength, and then optimize knee joint activity.
Objective:To investigate the effect of Xiangsha Zhizhu decoction combined with massage on gastric motility in patients with functional dyspepsia of spleen stomach weakness syndrome.Methods:Seventy-six patients with functional dyspepsia of spleen stomach weakness syndrome admitted to Linyi Traditional Chinese Medicine Hospital from May 2021 to March 2023 were selected as the research objects, and they were divided into control group and observation group according to random number table method, with 38 cases in each group. The control group received conventional western medicine treatment (trimebutine), while the observation group received Xiangsha Zhizhu decoction combined with massage treatment based on the treatment of the control group. Both groups were treated for 1 month. The clinical efficacy, gastric motility indicators, and levels of gastric hormones were compared between two groups.Results:The total effective rate of the observation group (97.37%, 37/38) was higher than that of the control group (76.31%, 29/38), P<0.05. There was no statistically significant difference in gastric motility indicators and levels of gastric hormones between the two groups before treatment ( P>0.05); after treatment, the peak and frequency of gastric antral contraction increased in both groups, and the two indicators of the observation group were higher than those of the control group, with a statistically significant difference ( P<0.05). After treatment, motilin increased, while gastrin (GAS) and somatostatin (SS) decreased in both groups. After treatment, MTL in the observation group was higher than that in the control group, while GAS and SS were lower than that in the control group, with a statistically significant difference ( P<0.05). Conclusions:The combination of Xiangsha Zhizhu decoction and massage can significantly improve clinical symptoms, enhance gastric motility, and regulate levels of gastric hormones in patients with functional dyspepsia of spleen and stomach weakness syndrome.
Objective:To compare and analyze the application value of thin computed tomography (CT) scanning and X-ray scanning in the diagnosis and differentiation of pulmonary fungal infection.Methods:A total of 124 patients with pulmonary fungal infection treated in Nanyang Central Hospital from March 2019 to August 2022 were selected and divided into control group and study group according to random number table method, with 62 cases in each group. X-ray scanning was used in the control group, and CT scanning was used in the study group. The positive detection rate of the two groups were counted, and the imaging findings of thin CT scanning were analyzed.Results:The positive detection rate of the study group was 75.81% (47/62), which was higher than the 16.13% (10/62) of the control group ( P<0.05). Among the 62 patients, CT imaging findings were mainly nodules or masses in 19 cases (30.65%, 19/62), cavities in 14 cases (22.58%, 14/62), halo sign in 13 cases (20.97%, 13/62), inflammatory infiltration in 7 cases (11.29%, 7/62), crescent sign in 6 cases (9.68%, 6/62). Conclusions:Compared with X-ray scanning, thin CT scanning has a higher positive detection rate in the diagnosis of pulmonary fungal infection, which can clearly show the signs of lung tissue and provide imaging basis for early clinical treatment.
Objective:To analyze the effect of tenofovir alafenamide fumarate tablets combined with Fuzheng Huayu capsule on hepatic fibrosis in patients with hepatitis B cirrhosis.Methods:Ninety-four patients with hepatitis B cirrhosis who were admitted to Luohe Central Hospital from January 2021 to December 2022 were selected. Patients were divided into control group and observation group according to random number table method, with 47 cases in each group. Patients in the control group were treated with tenofovir alafenamide fumarate tablets, while patients in the observation group were treated with tenofovir alafenamide fmarate tablets and Fuzheng Huayu capsule. The clinical efficacy and liver hardness were compared between the two groups.Results:The total effective rate of the observation group (95.74%, 45/47) was higher than that of the control group (82.98%, 39/47), P<0.05. After treatment, the liver hardness of both groups were lower than those before treatment, and the liver hardness of the observation group was (7.05±0.19) kPa, which was lower than the (7.89±0.17) kPa of the control group ( P<0.05). Conclusions:The combination of tenofovir alafenaminde fumarate tablets and Fuzheng Huayu capsule can improve the clinical efficacy and liver hardness of patients with hepatitis B cirrhosis.
Objective:To compare the curative effect of different doses of progesterone on anovulatory irregular menstruation.Methods:A total of 98 patients with anovulatory irregular menstruation admitted to Anyang People’s Hospital from January 2022 to December 2022 were selected, and they were divided into study group and control group according to the random number table method, with 49 cases in each group. The oral dose of progesterone in the control group was 400 mg/d, and the oral dose of progesterone in the study group was 200 mg/d. The clinical efficacy, clinical symptoms, menstrual recovery, levels of hormone, and adverse reactions were compared between the two groups.Results:There were no statistically significant differences in the total effective rate of treatment, vaginal bleeding time, vaginal bleeding volume, and endometrial thickness return-to-normal time between the two groups ( P>0.05). After treatment, there was no statistically significant difference in bleeding volume score, menstrual volume, menstrual cycle, and endometrial thickness between the two groups ( P>0.05). There were statistically significant differences in the levels of luteinizing hormone, estradiol, and follicle-stimulating hormone between the two groups after treatment ( P<0.05). The incidence of adverse reactions in the study group (4.08%, 2/49) was lower than that in the control group (18.37%, 9/49), P<0.05. Conclusions:Both 200 mg/d and 400 mg/d doses of progesterone are effective in treating anovulatory irregular menstruation, but the 200 mg/d dose is safer.
Objective:To analyze the risk factors for anal edge edema after Milligan-Morgan hemorrhoidectomy in patients with mixed hemorrhoids, and propose relevant preventive measures.Methods:Using cluster stratified sampling method, 78 patients with mixed hemorrhoids who underwent Milligan-Morgan hemorrhoidectomy in Pingdingshan Traditional Chinese Medicine Hospital from January 2020 to April 2023 were selected as the research subjects. The general data of patients with and without postoperative anal edge edema were compared. The risk factors for anal edge edema after Milligan-Morgan hemorrhoidectomy in patients with mixed hemorrhoids were calculated and analyzed by logistic regression equation.Results:Among the 78 patients, 35 patients developed postoperative anal edge edema, with an incidence of 44.87% (35/78). There was a statistically significant difference in age (<60 years, ≥60 years), gender, obesity, reasonable intraoperative procedures, and normal postoperative defecation between patients with and without postoperative anal edge edema ( P<0.05). There was no significant difference in suture of surgical incision and loosening of anal Sphincter between patients with and without postoperative anal edge edema ( P>0.05). The results of logistic regression analysis showed that age (<60 years, ≥60 years), gender, obesity, reasonable intraoperative procedures, and normal postoperative defecation were all risk factors for anal edge edema in patients with mixed hemorrhoids after ( P<0.05). Conclusions:The risk factors for anal edge edema after Milligan-Morgan hemorrhoidectomy for mixed hemorrhoids include age ≥ 60 years, female gender, obesity, improper intraoperative procedures, and abnormal defecation. Clinical management of these factors should be strengthened.
Objective:To investigate the clinical value of transvaginal color Doppler ultrasound (TVCDU) combined with hysteroscopy in the diagnosis of intrauterine space-occupying lesions.Methods:A total of 78 patients with intrauterine space-occupying lesions treated in NO. 989 Hospital of Joint Support Force from January 2020 to December 2022 were selected. They all underwent TVCDU and hysteroscopy. Pathological examination results were taken as the gold standard to analyze the diagnostic results and diagnostic efficacy of TVCDU, hysteroscopy and combination of them. And the predictive value was analyzed.Results:Among the 78 patients with intrauterine space-occupying lesions, 33 cases were malignant, and 45 cases were benign. TVCDU identified 22 cases of true malignancy and 37 cases of true benign. Hysteroscopy identified 24 cases of true malignancy and 38 cases of true benign; TVCDU combined with hysteroscopy identified 32 cases of true malignancy and 42 cases of true benign. The sensitivity and accuracy of TVCDU combined with hysteroscopy were 96.97% (32/33) and 94.87% (74/78), higher than those of TVCDU (66.67%, 22/33; 75.64%, 59/78) and hysteroscopy identified (72.73%, 24/33; 79.49%, 62/78). The missed diagnosis rate of TVCDU combined with hysteroscopy was 3.03% (1/33), lower than that the 33.33% (11/33) of TVCDU and 27.27% (9/33) of hysteroscopy ( P<0.05). The benign predictive value of TVCDU combined with hysteroscopy was 97.67% (42/43), higher than that of TVCDU (77.08%, 37/48) and hysteroscopy (80.85%, 38/47), P<0.05. Conclusions:TVCDU combined with hysteroscopy in the diagnosis of intrauterine space-occupying lesions can significantly improve the sensitivity and accuracy of malignant lesions, and reduce the occurrence of missed diagnosis, which has good predictive value.
Objective:To investigate the occurrence and influencing factors of cerebral microbleeds in patients with acute cerebral infarction.Methods:This study was a prospective cohort trail. A total of 114 patients with acute cerebral infarction treated in Henan Provincial People’s Hospital from January 2020 to January 2023 were selected. According to occurrence of cerebral microbleeds during the visit, the selected patients were divided into occurrence group and non-occurrence group. The baseline data of the two groups were counted and compared. Univariate and multivariate logistic regression analysis was used to test the influencing factors of cerebral microbleeds in patients with acute cerebral infarction.Results:Forty-two of 114 patients developed cerebral microbleeds, with an incidence of 36.84% (42/114). There were statistical significant differences in hypertension, 24-hour systolic blood pressure coefficient of variation (SBP-CV), 24-hour diastolic blood pressure coefficient of variation (DBP-CV), glomerular filtration rate, platelet distribution width and serum 25-hydroxyvitamin D between the two groups ( P<0.05). Results of logistic regression analysis showed that elevated 24 h SBP-CV, elevated 24 h DBP-CV, decreased glomerular filtration rate, decreased serum 25-hydroxyvitamin D, and increased platelet distribution width were related factors affecting the occurrence of cerebral microbleeds in patients with acute cerebral infarction ( P<0.05). Conclusions:The incidence of cerebral microbleeds in patients with acute cerebral infarction is relatively high, which is mainly influenced by 24 h SBP-CV, 24 h DBP-CV, glomerular filtration rate, serum 25-hydroxyvitamin D and platelet distribution width.
